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Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
Exagamglogene Autotemcel for Transfusion-Dependent β-Thalassemia
[New England Journal Of Medicine] The authors conducted an open-label, single-group, Phase III study of exa-cel in patients 12 to 35 years of age with transfusion-dependent β-thalassemia and a β0/β0, β0/β0-like, or non–β0/β0-like genotype.
Putting the STING Back into BH3-Mimetic Drugs for TP53-Mutant Blood Cancers
[Cancer Cell] Investigators reported that p53 was activated following BH3-mimetic induced mitochondrial outer membrane permeabilization, leading to BH3-only protein induction and thereby potentiating the pro-apoptotic signal.
Pyrimidine Depletion Enhances Targeted and Immune Therapy Combinations in Acute Myeloid Leukemia
[JCI Insight] Researchers introduced HOSU-53, a dihydroorotate dehydrogenase inhibitor with significant monotherapy activity, which was further enhanced when combined with other standard-of-care therapeutics.
Tyrosine Phosphorylation of CARM1 Promotes Its Enzymatic Activity and Alters Its Target Specificity
[Nature Communications] The authors showed that the hyperactivation of Janus kinase 2 by the V617F mutation phosphorylated tyrosine residues in coactivator-associated arginine methyltransferase 1 (CARM1), an important target in hematologic malignancies, increasing its methyltransferase activity and altering its target specificity.
Clinical Associations with a Polygenic Predisposition to Benign Lower White Blood Cell Counts
[Nature Communications] Researchers investigated the clinical consequences of a genetic predisposition toward lower white blood cell (WBC) counts among 89,559 biobank participants from tertiary care centers using a polygenic score for WBC count comprising single nucleotide polymorphisms not associated with disease.
SUCLG1 Restricts POLRMT Succinylation to Enhance Mitochondrial Biogenesis and Leukemia Progression
[EMBO Journal] Investigators reported that expression of tricarboxylic acid cycle enzyme succinate-CoA ligase SUCLG1 strongly correlated with electron transport chain genes across various TCGA cancer transcriptomes.
PML::RARA and GATA2 Proteins Interact via DNA Templates to Induce Aberrant Self-Renewal in Mouse and Human Hematopoietic Cells
[Proceedings Of The National Academy Of Sciences Of The United States Of America] Researchers defined the genomic binding sites of PML::RARA in primary mouse and human hematopoietic progenitor cells with V5-tagged PML::RARA, using anti-V5-PML::RARA chromatin immunoprecipitation sequencing and CUT&RUN approaches.
Recipient Clonal Hematopoiesis in Allogeneic Bone Marrow Transplantation for Lymphoid Malignancies
[Blood Advances] In this retrospective study, allogeneic blood and marrow transplantation (alloBMT) recipients age 60 and older with lymphoid malignancies were included. Among 97 consecutive patients who received alloBMT between 2017 and 2022, cloal hematopoiesis was detected in 60.
SMS121, a New Inhibitor of CD36, Impairs Fatty Acid Uptake and Viability of Acute Myeloid Leukemia
[Scientific Reports] A drug-like small molecule, SMS121, was identified by receptor-based virtual screening and experimentally demonstrated to target the lipid uptake protein CD36.
miR-214 Aggravates Oxidative Stress in Thalassemic Erythroid Cells by Targeting ATF4
[PLOS One] To understand how miR-214 aggravated oxidative stress in thalassemia erythroid cells, the authors investigated the molecular mechanism of miR-214 and its regulation of the oxidative status in thalassemia erythrocytes.
Of Gains and Losses: SAMD9/SAMD9L and Monosomy 7 in Myelodysplastic Syndrome
[Experimental Hematology] Germline gain-of function (GOF) SAMD9/SAMD9L mutations cause different syndromes with predisposition to myeloid neoplasms in the young. Primary somatic compensation mutations in the blood are very frequent in patients with germline GOF SAMD9/SAMD9L-related diseases.
Robert Zeiser Receives DKMS Mechtild Harf Science Award
[CIBSS - Centre for Integrative Biological Signalling Studies] The DKMS Stiftung Leben Spenden has honoured CIBSS member Prof. Dr Robert Zeiser for his outstanding research work in the field of allogeneic stem cell transplantation.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
