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Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
Bone Marrow CD8+ Trm Cells Induced by IL-15 and CD16+ Monocytes Contribute to HSPC Destruction in Human Severe Aplastic Anemia
[Clinical Immunology] Scientists performed single-cell RNA sequencing of peripheral blood and bone marrows and bone marrow mononuclear cells from severe aplastic anemia patients and healthy donors and identified a CD8+ T cell subset with a tissue residency phenotype (Trm) in bone marrow that exhibited high IFN-γ and FasL expression and have a higher ability to induce apoptosis in hematopoietic stem and progenitor cells in vitro through FasL expression.
Mitochondrial tRNA Pseudouridylation Governs Erythropoiesis
[Blood] Researchers investigated the role of tRNA pseudouridylation in erythropoiesis and its association with mitochondrial myopathy, lactic acidosis, and sideroblastic anemia syndrome pathogenesis.
Integrative Single-Cell Chromatin and Transcriptome Analysis of Human Plasma Cell Differentiation
[Blood] Scientists combined single cell RNA-seq and single cell ATAC-seq to decipher the trajectories involved in plasma cell differentiation.
Monash Cord Blood Cell Therapy Research Recognised with Multiple Awards
[Monash University] Congratulations to Dr. Lindsay Zhou on receiving the Perinatal Research Society Mont Liggins Award and the Cerebral Palsy Alliance Award from the Perinatal Society of Australia and New Zealand for his research on cord blood cell therapy.
Caspase 8 Deletion Causes Infection/Inflammation-Induced Bone Marrow Failure and MDS-Like Disease in Mice
[Cell Death & Disease] Caspase 8 (Casp8) is a master regulator of pyroptosis, apoptosis, and necroptosis (PANoptosis). To study the role of PANoptosis in hematopoiesis, scientists generated inducible Casp8 knockout mice.
Immunoglobulin Replacement vs Prophylactic Antibiotics for Hypogammaglobulinemia Secondary to Hematological Malignancy
[Blood Advances] In this randomized controlled feasibility trial conducted in seven hospitals in Australia and New Zealand, scientists enrolled patients with secondary hypogammaglobulinemia with either a history of recurrent/severe infection or an immunoglobulin G level less than 4 g/L.
The DMT1 Isoform Lacking the Iron-Response Element Regulates Normal and Malignant Hematopoiesis via NOTCH Pathway Activation
[FEBS Letters] The authors investigated the function of DMT1 isoform lacking the iron-response element in normal and malignant hematopoiesis.
Small-Molecule α-Lipoic Acid Targets ELK1 to Balance Human Neutrophil and Erythrocyte Differentiation
[Stem Cell Research & Therapy] In vitro culture of isolated CD34+, common myeloid progenitors, and CD34+ CD371– hematopoietic stem progenitor cells were performed to assay the differentiation potential of monocytes, neutrophils, and erythrocytes.
Regulation of Erythroid Differentiation via the HIF1α-NFIL3-PIM1 Signaling Axis under Hypoxia
[Antioxidants & Redox Signaling] Scientists studied the effect and mechanism of hypoxia on erythroid differentiation of K562 cells and observed the effect of hypoxia on early erythropoiesis of zebrafish.
GM-CSF Receptor Expression Determines Opposing Innate Memory Phenotypes at Different Stages of Myelopoiesis
[Blood] Researchers showed that GM-CSF programmmed myeloid committed progenitors to produce trained macrophages but programmed the upstream non-committed LKS+ progenitors to produce tolerized macrophages.
Mutation Patterns Predict Drug Sensitivity in Acute Myeloid Leukemia
[Clinical Cancer Research] Investigators performed targeted sequencing, high-throughput drug screening, and single-cell genomic profiling on leukemia cell samples derived from patients with AML.
Role of Reactive Oxygen Species in Myelodysplastic Syndromes
[Cellular & Molecular Biology Letters] The authors review the eminent role of reactive oxygen species in the hematological niche and their profound influence on the progress of myelodysplastic syndromes.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
