Hematopoiesis News

Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.

Resilient Anatomy and Local Plasticity of Naive and Stress Hematopoiesis

[Nature] Scientists developed strategies to image multipotent hematopoiesis, erythropoiesis, and lymphopoiesis in mice. They combined these with imaging of myelopoiesis to define the anatomy of normal and stress hematopoiesis.

Impact of CRISPR/HDR Editing versus Lentiviral Transduction on Long-Term Engraftment and Clonal Dynamics of HSPCs in Rhesus Macaques

[Cell Stem Cell] To track the output and clonality of homology-directed repair-edited cells and to provide a comparison to lentivirally transduced HSCs in vivo, investigators developed a competitive rhesus macaque autologous transplantation model.

S-Nitrosylation-Triggered Unfolded Protein Response Maintains Hematopoietic Progenitors in Drosophila

[Developmental Cell] Scientists identified the expression of nitric oxide synthase in blood progenitors, generating nitric oxide for post-translational S-nitrosylation of protein cysteine residues.

Fetal Liver Macrophages Contribute to the Hematopoietic Stem Cell Niche by Controlling Granulopoiesis

[eLife] Using a single-cell omics approach combined with spatial proteomics and genetic fate-mapping models, researchers found that fetal liver macrophages clustered into distinct yolk sac-derived subpopulations and that long-term HSCs were interacting preferentially with one of the macrophage subpopulations.

SF3B1 Mutations Provide Genetic Vulnerability to Copper Ionophores in Human Acute Myeloid Leukemia

[Science Advances] In a phenotypical screen of 56 AML patient samples and using a library of 10,000 compounds, investigators identified a hit with increased sensitivity toward SF3B1-mutated and adverse risk AMLs.

Differential Prognostic Values of the Three AKT Isoforms in Acute Myeloid Leukemia

[Scientific Reports] The authors revealed that AKT3 behaved very distinctly than AKT1M or AKT2 in both normal myeloid differentiation and AML.

Clonal Hematopoiesis and Its Impact on the Aging Osteo-Hematopoietic Niche

[Leukemia] Scientists review the changes in the aging bone marrow (BM) niche and the emerging evidence supporting the concept that clonal hematopoiesis can progressively alter components of the local BM microenvironment.

Takeda Announces Approval of ADZYNMA® Intravenous Injection 1500 (Apadamtase Alfa /Cinaxadamtase Alfa) in Japan for Patients with Congenital Thrombotic Thrombocytopenic Purpura (cTTP)

[Takeda] Takeda announced that the Japanese Ministry of Health, Labour and Welfare has approved the use of ADZYNMA for the treatment of cTTP for individuals 12 years of age and older.

Loss of RNA-Binding Protein CELF2 Promotes Acute Leukemia Development via FAT10-mTORC1

[Oncogene] The authors showed that Celf2 deficiency in hematopoietic system led to enhanced HSCs self-renewal and differentiation toward myeloid cells in mice.

The Histone Acetyltransferase KAT6B Is Required for Hematopoietic Stem Cell Development and Function

[Stem Cell Reports] Using Kat6b germline deletion and overexpression in mice, we determined the role of KAT6B in the hematopoietic system.

The TLK-ASF1 Histone Chaperone Pathway Plays a Critical Role in IL-1b-Mediated AML Progression

[Blood] Through RNA-sequencing analysis, researchers identified that IL-1 upregulated anti-silencing function-1B (ASF1B), a histone chaperone, in AML progenitors compared to healthy progenitors.

FDA Adcomm Backs J&J’s Carvykti, BMS’s Abecma Early in Multiple Myeloma

[BioSpace] The risks of early death in the trials of Johnson & Johnson and Legend Biotech’s Carvykti and Bristol Myers Squibb and 2seventyBio’s Abcema were not a significant concern for the FDA’s Oncologic Drugs Advisory Committee, which voted 11-0 and 8-3 respectively to support the approvals of the CAR-T therapies as earlier lines of treatment for multiple myeloma.

Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.

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