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Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
CRKL but Not CRKII Contributes to Hemin-Induced Erythroid Differentiation of CML
[Journal of Cellular and Molecular Medicine] miR-429-CT10 regulation of kinase-like (CRKL) upregulation was negatively correlated with miR-429 downregulation in both chronic myeloid leemia (CML) patient and CR patient samples.
FLT3L Governs the Development of Partially Overlapping Hematopoietic Lineages in Humans and Mice
[Cell] The authors described three humans homozygous for a loss-of-function FMS-related tyrosine kinase 3 ligand (FLT3L) G variant with a history of various recurrent infections, including severe cutaneous warts.
Targeting Hyperactive Platelet-Derived Growth Factor Receptor-β Signaling in T Cell Acute Lymphoblastic Leukemia and Lymphoma
[Haematologica] Investigators reported a novel MYH9::PDGFRB fusion in a T-cell lymphoblastic lymphoma patient, and demonstrated that this fusion product was constitutively active and sufficient to drive oncogenic transformation in vitro and in vivo.
Molecular, Clinical, and Therapeutic Determinants of Outcome in NPM1 Mutated Aml
[Blood] Researchers analyzed a large group of patients with NPM1mutated AML enrolled in prospective trials to delineate the impact of baseline molecular and clinical features, post induction measurable residual disease status and treatment intensity on outcome.
Treatment of Chronic-Phase Chronic Myeloid Leukemia in Patients Randomized to Dasatinib or Imatinib after Suboptimal Responses to Three Months of Imatinib Therapy: Final 5-Year...
[Haematologica] DASCERN was a prospective, Phase IIb, randomized trial evaluating a switch to dasatinib in patients who have not achieved early molecular response after three months of treatment with first-line imatinib.
A Phase IIIb Study of Venetoclax and Azacitidine or Decitabine in an Outpatient Setting in Patients with Acute Myeloid Leukemia
[Hematological Oncology] This study evaluated the efficacy and safety of venetoclax plus hypomethylating agent in a United States community–based outpatient setting in patients with newly diagnosed AML who were treatment naïve for AML.
Aberrant Ecotropic Viral Integration Site-1 (EVI-1) and Myocyte Enhancer Factor 2 C Gene (MEF2C) in Adult Acute Myeloid Leukemia Are Associated with Adverse T...
[Annals Of Hematology] This prospective study involved 80 adult de novo AML patients recruited from Oncology Center, Mansoura University, between March 2019 and July 2021. The MEF2C and EVI1 expression were measured using a Taqman probe-based qPCR assay.
Provectus Biopharmaceuticals Announces Notice of Allowance for US Patent of Oral Administration of Rose Bengal Sodium in Hematology (Leukemia)
[Provectus Biopharmaceuticals, Inc.] Provectus Biopharmaceuticals, Inc.announced that the United States Patent and Trademark Office has allowed patent application 17/232,393, titled “Halogenated Xanthene Composition and Method for Treating Hematologic Cancers”.
Molecular, Clinical, and Therapeutic Determinants of Outcome in NPM1 Mutated AML
[Journal of Cellular and Molecular Medicine] Researchers analyzed a large group of patients with NPM1mutated AML enrolled in prospective trials to delineate the impact of baseline molecular and clinical features, post induction measurable residual disease status and treatment intensity on outcome.
miRNA-7145-cuedc2 Axis Controls Hematopoiesis through JAK1/STAT3 Signaling Pathway
[Cell Death Discovery] The authors showed that miRNA-7145, a miRNA with previously unknown function, was enriched in erythrocytes at the definitive wave, but not expressed in myeloid cells.
Measurable Residual FLT3 Internal Tandem Duplication before Allogeneic Transplant for Acute Myeloid Leukemia
[Jama Oncology] In this cohort study, DNA sequencing was performed on first CR blood from patients with FLT3-internal tandem duplication AML transplanted from March 2013 to February 2019.
Advances in Hematopoietic Stem Cells Ex Vivo Expansion Associated with Bone Marrow Niche
[Annals Of Hematology] Investigators outline the basic biology characteristics of HSCs, and focus on the regulatory factors in bone marrow niche affecting the functions of HSCs.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
