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Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
An Age-Progressive Platelet Differentiation Path from Hematopoietic Stem Cells Causes Exacerbated Thrombosis
[Cell] The authors revealed a direct differentiation pathway from HSCs into platelets that is progressively propagated upon aging. The aging-enriched platelet path was decoupled from all other hematopoietic lineages, including erythropoiesis, and operated as an additional layer in parallel with canonical platelet production.
Autophagy Counters Inflammation-Driven Glycolytic Impairment in Aging Hematopoietic Stem Cells
[Cell Stem Cell] Scientists demonstrated that autophagy was an adaptive cytoprotective response to chronic inflammation in the aging murine bone marrow niche.
Molecular Subgroups of T Cell Acute Lymphoblastic Leukemia in Adults Treated According to Pediatric-Based GMALL Protocols
[Leukemia] Researchers presented a homogenously treated cohort of 230 adult T-lineage lymphoblastic leukemia patients characterized on transcriptome, and partly on DNA methylation and gene mutation level in correlation with clinical outcome. THey identified nine molecular subgroups based on aberrant oncogene expression correlating to four distinct DNA methylation patterns.
TIF1β Activates Leukemic Transcriptional Program in HSCs and Promotes BCR::ABL1-Induced Myeloid Leukemia
[Leukemia] Scientists generated a BCR::ABL1 conditional knock-in (KI) mouse model, which developed aggressive myeloid leukemia, and demonstrated that the deletion of the Tif1β gene inhibited the progression of myeloid leukemia and showed longer survival than that in BCR::ABL1 KI mice
CUX1 Regulates Human Hematopoietic Stem Cell Chromatin Accessibility via the BAF Complex
[Cell Reports] The authors demonstrated that CUT-like homeobox 1 (CUX1) directed the BAF chromatin remodeling complex to DNA to increase chromatin accessibility in hematopoietic cells.
A JAGN1-Associated Severe Congenital Neutropenia Zebrafish Model Revealed an Altered G-CSFR Signaling and UPR Activation
[Blood Advances] There is a limited availability of primary HSCs from JAGN1-congenital neutropenia (CN) patients and the absence of animal models to study the mechanism by which autosomal recessive mutations in the JAGN1 gene cause severe CN. Scientists addressed these limitations by establishing a zebrafish model of JAGN1-CN.
An Intricate Regulatory Circuit between FLI1 and GATA1/GATA2/LDB1/ERG Dictates Erythroid vs. Megakaryocytic Differentiation
[Molecular Medicine Reports] Using the megakaryocytic erythroid progenitor‑like cell line HEL western blotting, RT‑qPCR, lentivirus‑mediated downregulation, flow cytometry as well as chromatin immunoprecipitation assay demonstrated that the E26 transformation‑specific transcription factor friend leukemia integration factor 1 (Fli‑1) inhibited erythroid differentiation.
DNMT1 Regulates Human Erythropoiesis by Modulating Cell Cycle and Endoplasmic Reticulum Stress in a Stage-Specific Manner
[Cell Death & Differentiation] The authors found that DNA methyltransferase 1 (DNMT1) deficiency led to cell cycle arrest of erythroid progenitors which was partially rescued by treatment with a p21 inhibitor UC2288.
Complexities of Modeling the Bone Marrow Microenvironment to Facilitate Hematopoietic Research
[Experimental Hematology] HSCs interacted with endothelial cells via specific cell adhesion molecules. Endothelial cells also secreted several factors important for HSC homeostasis and proliferation.
Elevating Fetal Hemoglobin – Recently Discovered Regulators and Mechanisms
[Blood] Investigators survey recent developments, spurred by the discovery of CRISPR tools that enabled for the first time high throughput genetic screens for new molecules that impact the fetal to adult hemoglobin switch.
$5 Million Grant Supports Innovative Immunotherapies against Blood Cancers
[Washington University School of Medicine in St. Louis] Researchers at Washington University School of Medicine in St. Louis have received a $5 million grant from the Leukemia & Lymphoma Society to support research aimed at developing new immunotherapies for different types of blood-based cancers.
TFPI from Erythroblasts Drives Heme Production in Central Macrophages Promoting Erythropoiesis in Polycythemia
[Nature Communications] Investigators discovered that an anticoagulant protein tissue factor pathway inhibitor (TFPI) played an essential role in erythropoiesis via the control of heme biosynthesis in central macrophages.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
