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Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
Formation of Recurring Transient Ca2+-Based Intercellular Communities during Drosophila Hematopoiesis
[Proceedings Of The National Academy Of Sciences Of The United States Of America] The authors revealed that tissue scale signaling regulation could arise from local gap-junction mediated cell–cell signaling through the spatiotemporal establishment of an intermediate-scale of transient multicellular communication communities over the course of tissue development.
Atrial Fibrillation and Clonal Hematopoiesis in TET2 and ASXL1
[Jama Cardiology] Researchers determined whether clonal hematopoiesis of indeterminate potential was associated with atrial fibrillation, inflammatory and cardiac biomarkers, and cardiac structural changes.
Survivors of Polymicrobial Sepsis Are Refractory to G-CSF-Induced Emergency Myelopoiesis and Hematopoietic Stem and Progenitor Cell Mobilization
[Stem Cell Reports] The authors treated recovered sham and cecal ligation and puncture mice with a mobilizing regimen of granulocyte colony-stimulating factor (G-CSF) at day 20 post-surgery.
McPh1, Mutated in Primary Microcephaly, Is Also Crucial for Erythropoiesis
[EMBO Reports] Scientists revealed that microcephalin (Mcph1)-knockout mice exhibited congenital macrocytic anemia due to impaired terminal erythroid differentiation during fetal development.
Early-Wave Macrophages Control Late Hematopoiesis
[Developmental Cell] Investigators showed that loss of early-wave macrophages in Drosophila and mice accelerated late hematopoiesis, which did not correlate with inflammation and did not rely on macrophage phagocytic ability.
Proteinase 3 Depletion Attenuates Leukemia by Promoting Myeloid Differentiation
[Cell Death & Differentiation] Researchers showed that the genetic elimination of proteinase 3 (PRTN3) in mice led to spontaneous myeloid differentiation. Mechanistically, their findings indicated that PRTN3 interacted with the N-terminal of STAT3, serving as a negative regulator of STAT3-dependent myeloid differentiation.
Circadian Disturbances by Altering the Light–Dark Cycle Negatively Affects Hematopoietic Function of Bone Marrow in Mice
[FASEB Journal] The authors exposed C57bl/6j mice to repeated reversed light–dark cycles for 90 days to research the effects of circadian disturbance on bone marrow hematopoietic function.
Pre-frailty after Blood or Marrow Transplantation and the Risk of Subsequent Mortality
[Leukemia] Investigators examined the prevalence, risk factors, and association between pre-frailty and subsequent mortality after blood or marrow transplantation.
Essential Thrombocythaemia: A Contemporary Approach with New Drugs on the Horizon
[British Journal of Haematology] Investigators focus on the evolving landscape of treatment strategies in essential thrombocythemia, with an emphasis on the role of molecular profiling in guiding therapeutic decisions.
Syros Receives Fast Track Designation from the FDA for Tamibarotene for the Treatment of Newly Diagnosed Unfit AML with RARA Gene Overexpression
[Syros Pharmaceuticals] Syros Pharmaceuticals announced that the US FDA has granted Fast Track Designation to tamibarotene in combination with azacitidine and venetoclax for the treatment of newly diagnosed AML with RARA overexpression.
Loss of Stress Sensor GADD45A Promotes Stem Cell Activity and Ferroptosis Resistance in LGR4/HOXA9-Dependent AML
[Blood] Researchers defined GADD45A as a key downstream target of LGR4 oncogenic signaling and discover a regulatory role for GADD45A loss in promoting leukemia-initiating activity and oxidative resistance in LGR4/HOXA9-dependent AML, a poor prognosis subset of leukemia.
Optimized BEAC Conditioning Regimen Improves Clinical Outcomes of Autologous Hematopoietic Stem Cell Transplantation in Non-Hodgkin Lymphomas
[International Journal of Hematology] Scientists explored the efficacy and safety of an optimized BEAC (adjusted-dose, intermediate-dose cytarabine and reduced-dose cyclophosphamide, AD-BEAC) conditioning regimen for non-Hodgkin lymphoma.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
