Lysine-Specific Histone Demethylases in Normal and Malignant Hematopoiesis|
During the last ten years, mounting evidence implicates the family of lysine-specific histone demethylases as critical regulators of normal hematopoiesis, whereas their deregulation is found in a broad spectrum of hematopoietic malignancies. The authors review recent findings on the role of these enzymes in normal and malignant hematopoiesis to highlight how aberrant epigenetic regulation facilitates hematopoietic cell transformation through subversion of cell fate and lineage commitment programs. [Exp Hematol] Abstract
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NEW T-ALL Workshop|
March 17-19, 2016
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