Volume 7.18 | May 10

Hematopoiesis News 7.18 May 10, 2016
Hematopoiesis News
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Single-Cell Transcriptional Analysis of Normal, Aberrant, and Malignant Hematopoiesis in Zebrafish
Researchers have transcriptionally profiled single hematopoietic cells from zebrafish to define erythroid, myeloid, B, and T cell lineages. They used their approach to identify hematopoietic stem and progenitor cells and a novel NK-lysin 4+ cell type, representing a putative cytotoxic T/NK cell. [J Exp Med] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Enhanced Thrombopoietin but Not G-CSF Receptor Stimulation Induces Self-Renewing Hematopoietic Stem Cell Divisions In Vivo
Using in vivo high-resolution single hematopoietic stem cells (HSC) divisional tracking, investigators demonstrated that clinically applied thrombopoietin receptor but not granulocyte-colony stimulating factor receptor agonists drive HSCs into self-renewing divisions leading to quantitative expansion of functional HSC as defined by their in vivo serial multi-lineage and long-term repopulating potential. [Blood] Abstract

Mesenchymal Stromal Cell Derived Extracellular Vesicles Rescue Radiation Damage to Murine Marrow Hematopoietic Cells
The authors evaluated the capacity of mesenchymal stromal cells-derived extracellular vesicles to mitigate radiation injury to marrow stem cells at four hours to seven days after irradiation. [Leukemia] Abstract

Xpg Limits the Expansion of Hematopoietic Stem and Progenitor Cells after Ionizing Radiation
Scientists screened for genome stability factors negatively impacting maintenance of hematopoietic stem cells (HSCs) in the context of ionizing radiation (IR). They found that in vivo knock down of Xeroderma pigmentosum, complementation group G (Xpg) caused elevation of HSC numbers after IR treatment, while numbers of hematopoietic progenitors are elevated to a lesser extent. [Nucleic Acids Res] Full Article

Systematic Cellular Disease Models Reveal Synergistic Interaction of Trisomy 21 and GATA1 Mutations in Hematopoietic Abnormalities
To better understand functional interplay between trisomy 21 and GATA1 mutations in hematopoiesis, scientists constructed cellular disease models using human induced pluripotent stem cells (iPSCs) and genome-editing technologies. Comparative analysis of these engineered iPSCs demonstrated that trisomy 21 perturbed hematopoietic development through the enhanced production of early hematopoietic progenitors and the upregulation of mutated GATA1. [Cell Rep] Full Article | Graphical Abstract

RNA Polymerase III Component Rpc9 Regulates Hematopoietic Stem and Progenitor Cell Maintenance in Zebrafish
Researchers isolated a zebrafish mutant with defective T lymphopoiesis and positional cloning identified that Rpc9, a component of DNA-directed RNA polymerase III complex, is responsible for the mutant phenotype. [Development] Abstract

Measuring ATP Concentration in a Small Number of Murine Hematopoietic Stem Cells
Scientists showed the method of measuring the ATP levels in hematopoietic stem cells (HSCs) sorted from murine bone marrow. They used magnetic sorting as well as a cell sorter and adopted the commonly used bioluminescence-based detection kits in described protocol. Their strategy allows to measure ATP levels in 1000 highly purified HSC. [Methods Mol Biol] Abstract

Deorphanization and Characterization of the Ectopically Expressed Olfactory Receptor OR51B5 in Myelogenous Leukemia Cells
Scientists detected the expression of OR51B5 in the chronic myelogenous leukemia cell line K562 and in white blood cell samples of clinically diagnosed acute myelogenous leukemia patients by reverse transcription-PCR and immunocytochemical staining. [Cell Death Disc] Full Article


Allogeneic Transplantation Is Not Superior to Chemotherapy in Most Patients over 40 Years of Age with Philadelphia-Negative Acute Lymphoblastic Leukemia in First Remission
The authors retrospectively compared the outcome of patients >40 years treated with hematopoietic stem-cell transplantation (HSCT) or chemotherapy alone in first remission. Three-year overall survival and disease-free survival were not significantly different between the chemotherapy-only and HSCT groups [Am J Hematol] Abstract

Use of an Oral Busulfan Test Dose in Patients Undergoing Hematopoietic Stem Cell Transplantation Treated with or without Fludarabine
Researchers investigated the importance of an oral test dose for busulfan (BU) dose adjustment before conditioning regimen for hematopoietic stem cell transplantation and the effect of fludarabine on the oral BU pharmacokinetics evaluated after the 5th treatment dose. [J Clin Pharmacol] Abstract

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The Shelterin Complex and Hematopoiesis
The authors introduce the biochemical features and in vivo effects of individual shelterin proteins, discuss shelterin functions in hematopoiesis, and review emerging knowledge implicating the shelterin complex in hematological disorders. [J Clin Invest] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.
Yissum and BioTheryX Sign Licensing Agreement for the Development of Next-Generation Protein Degradation and Immunomodulatory Treatment for Hematological Cancers
Yissum Research Development Company of the Hebrew University of Jerusalem announced that it had signed an exclusive world-wide licensing and research agreement with BioTheryX, Inc., developer of novel protein degradation and immunomodulatory drugs for cancer and immune dysfunction, for the development and commercialization of drug candidates representing first-in-class therapy for hematologic and solid malignancies. [Yissum Research Development Company of the Hebrew University of Jerusalem] Press Release

FDA Expands IMBRUVICA® (Ibrutinib) Label to Include New Data from Two Key Phase III Trials, Adding Overall Survival and Combination Data
The U.S. Food and Drug Administration (FDA) has approved an expansion to the IMBRUVICA® U.S. Prescribing Information based on data supporting its use in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma, Janssen announced. [Janssen Global Services, LLC] Press Release

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Therapeutic Goods Administration (Australia)
NEW Worldwide Innovative Networking in Personalized Cancer Medicine (WIN) 2016
June 27-28, 2016
Paris, France

Visit our events page to see a complete list of events in the hematopoiesis community.
NEW PhD Student – Leukemia Biology (Helmholtz Association)

NEW Postdoctoral Fellow – Leukemia Lymphoma (Emory University)

Scientist – Hematology (STEMCELL Technologies Inc.)

Postdoctoral Scientist – Mouse Hematopoiesis (Lund University)

Postdoctoral Fellow – Hematopoietic Stem Cell Biology and Blood Disorders (Brigham & Women’s Hospital)

Research Technician – Hematopoietic Stem Cell Biology (Fred Hutchinson Cancer Research Center)

Postdoctoral Research Associate – Stem Cell Aging Biology (University of Southern California)

Postdoctoral Fellow – Hematopoietic Stem Cells (University of Pennsylvania)

Postdoctoral Fellow – Hematology/Oncology (Boston Children’s Hospital)

Assistant/Associate/Full Member Faculty – Myeloid Malignancies (Fred Hutchinson Cancer Research Center)

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