Volume 7.11 | Mar 22

Hematopoiesis News 7.11 March 22, 2016
Hematopoiesis News
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CD82/KAI1 Maintains the Dormancy of Long-Term Hematopoietic Stem Cells through Interaction with DARC-Expressing Macrophages
The authors examined the role of CD82/KAI1 in niche-mediated long-term repopulating hematopoietic stem cell (LT-HSC) maintenance. They found that CD82/KAI1 is expressed predominantly on LT-HSCs and rarely on other hematopoietic stem-progenitor cells. [Cell Stem Cell] Abstract | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
The Role of Fas-Associated Phosphatase 1 in Leukemia Stem Cell-Persistence during Tyrosine Kinase Inhibitor-Treatment of Chronic Myeloid Leukemia
Researchers directly tested the role of Fas-associated phosphatase 1 (Fap1) in chronic myeloid leukemia-leukemia stem cell-persistence using an in vivo murine model. In tyrosine kinase inhibitor (TKI) treated mice, they found that inhibiting Fap1, using a tripeptide or small molecule, prevented TKI-resistance, blast crisis and relapse after TKI-discontinuation; all events observed with TKI alone. [Leukemia] Abstract

Mitotic History Reveals Distinct Stem Cell Populations and Their Contributions to Hematopoiesis
Using a conditional histone 2B-mCherry-labeling mouse model, scientists characterized hematopoietic stem cell and progenitor proliferation dynamics in steady state and following several types of induced stress. [Cell Rep] Full Article | Graphical Abstract

Genome-Wide RNAi Screen Identifies Cohesin Genes as Modifiers of Renewal and Differentiation in Human HSCs
To gain insights into the regulatory mechanisms of hematopoietic stem cells (HSCs), researchers employed a genome-wide RNAi screen in human cord-blood derived cells and identified candidate genes whose knockdown maintained the HSC phenotype during culture. [Cell Rep] Full Article | Graphical Abstract | Press Release

Promotion of Expansion and Differentiation of Hematopoietic Stem Cells by Interleukin-27 into Myeloid Progenitors to Control Infection in Emergency Myelopoiesis
Among various types of hematopoietic cells in bone marrow, interleukin-27 predominantly and continuously promoted the expansion of only LineageSca-1+c-Kit+ cells, especially long-term repopulating hematopoietic stem cells and myeloid-restricted progenitor cells with long-term repopulating activity, and the differentiation into myeloid progenitors in synergy with stem cell factor. [PLoS Pathog] Full Article

CDKIs p18INK4c and p57Kip2 Are Involved in Quiescence of CML Leukemic Stem Cells after Treatment with TKI
The authors analyzed cell cycle status, the levels of several cyclin dependent kinase inhibitors (CDKIs) and the subcellular localization of such molecules in different chronic myeloid leukemia (CML) cell lines, as well as primary CD34+CD38lin leukemic stem cells and hematopoietic stem cells. [Cell Cycle] Abstract

Meis1 Is Required for Adult Mouse Erythropoiesis, Megakaryopoiesis and Hematopoietic Stem Cell Expansion
Findings obtained from two inducible Meis1 knockout models confirm and extend previous reports of the essential role of Meis1 in adult hematopoietic stem cell maintenance and expansion and provide new evidence that highlights key roles of Meis1 in both megakaryopoiesis and erythropoiesis. [PLoS One] Full Article


Late Effects in Patients with Fanconi Anemia following Allogeneic Hematopoietic Stem Cell Transplantation from Alternative Donors
Researchers performed a retrospective analysis of 22 patients with Fanconi anemia and aplastic anemia, myelodysplastic syndrome or acute myelogenous leukemia who underwent a hematopoietic stem cell transplantation (HSCT) at Memorial Sloan Kettering Cancer Center and survived at least one year post HSCT. [Bone Marrow Transplant] Abstract

Allogeneic Stem Cell Transplantation for Patients with T315I BCR-ABL Mutated Chronic Myeloid Leukemia
The authors report the outcome of stem cell transplantation in 22 patients with T315I+ chronic myeloid leukemia patients, the majority of which from haploidentical family donors. [Biol Blood Marrow Transplant] Abstract

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“Krüppeling” Erythropoiesis: An Unexpected Broad Spectrum of Human Red Blood Bell Disorders Due to KLF1 Variants Unveiled by Genomic Sequencing
The authors discovered that a broad range of hitherto unrelated human red cell disorders are caused by variants in KLF1, a master regulator of erythropoiesis, previously considered to be extremely rare causes of human genetic disease. [Blood] Abstract

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Cord Blood World Europe
Kite Pharma Announces Clinical and Manufacturing Updates on KTE-C19 and MAGE-A3 Product Candidates
Kite Pharma, Inc. announced two oral presentations and two poster presentations to be delivered. The oral presentations will address KTE-C19, Kite’s lead chimeric antigen receptor product candidate, and, separately, an engineered T cell receptor product candidate targeting the cancer testis antigen MAGE-A3. [Press release from Kite Pharm, Inc. discussing research to be presented at the American Association for Cancer Research (AACR) Annual Meeting 2016, New Orleans] Press Release

Celator Announces Phase III Trial for VYXEOS™ (CPX-351) in Patients with High-Risk Acute Myeloid Leukemia Demonstrates Statistically Significant Improvement in Overall Survival
Celator Pharmaceuticals, Inc. announced positive results from the Phase III trial of VYXEOS™ Liposome for Injection in patients with high-risk acute myeloid leukemia compared to the standard of care regimen of cytarabine and daunorubicin known as 7+3. [Press release from Celator Pharmaceuticals, Inc. discussing research to be presented at the American Society of Clinical Oncology (ASCO) 2016 Annual Meeting, Chicago] Press Release

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Kite Pharma Announces Clinical Collaboration to Evaluate Two Novel Immunotherapies for Patients with Non-Hodgkin Lymphoma
Kite Pharma, Inc. announced that it has entered into a clinical trial collaboration with Genentech, a member of the Roche Group, to evaluate the safety and efficacy of KTE-C19, in combination with atezolizumab, in patients with refractory, aggressive non-Hodgkin lymphoma. [Kite Pharma, Inc.] Press Release

Collaboration to Develop Cancer Therapeutics
Harvard University has entered into an exclusive license and research collaboration agreement with Merck to further the development of small-molecule therapeutics for leukemia and other cancers. The novel compounds, developed in the laboratory of Harvard scientist Matthew Shair, offer an innovative approach to cancer treatment, targeting enzymes that regulate transcription. [Harvard University] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Hematopoietic Stem Cells: From the Embryo to the Aging Organism
June 3-5, 2016
Heidelberg, Germany

Visit our events page to see a complete list of events in the hematopoiesis community.
NEW Scientist – Hematology (STEMCELL Technologies Inc.)

NEW Postdoctoral Fellow – Molecular and Cellular Basis of Hematopoiesis (University of Cincinnati)

Postdoctoral Research Associate – Blood Stem cell Microenvironment (University of Illinois)

Associate Scientist – Hematopoietic Stem Cell Biology (Editas Medicine)

Research Associate – Hematopoietic Stem Cell Biology (Editas Medicine)

Postdoctoral Fellow Positions – Leukemogenesis (The University of Alabama)

Postdoctoral Fellow – Hematology/Oncology (Boston Children’s Hospital)

Postdoctoral Fellow – Cancer Stem Cell Biology (McGill University Health Center)

Postdoctoral Fellow – Cancer Biology (National University of Singapore)

PhD Position – Leukemogenesis and Treatment Resistance (Institute for Tumor Biology and Experimental Therapy)

Translational Research Scientist – Hematology/Oncology (University of Chicago)

Postdoctoral Associate – Epigenetic Regulation of Normal and Leukemic Stem Cells (Sanford Burnham Prebys Medical Discovery Institute)

Assistant/Associate/Full Member Faculty – Myeloid Malignancies (Fred Hutchinson Cancer Research Center)

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