Volume 7.03 | Jan 26

Hematopoiesis News 7.03 January 26, 2016
Hematopoiesis News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Mitofusin 2 Maintains Hematopoietic Stem Cells with Extensive Lymphoid Potential
Researchers showed in mice that the short isoform of a critical regulator of hematopoietic stem cells, Prdm16, induces mitofusin 2, a protein involved in mitochondrial fusion and in tethering of mitochondria to the endoplasmic reticulum. [Nature] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Histone Demethylase KDM2B Regulates Lineage Commitment in Normal and Malignant Hematopoiesis
Scientists identified histone demethylase KDM2B as a critical regulator of definitive hematopoiesis and lineage commitment of murine hematopoietic stem and progenitor cells. [J Clin Invest] Full Article

Aberrant Notch Signaling in the Bone Marrow Microenvironment of Acute Lymphoid Leukemia Suppresses Osteoblast-Mediated Support of Hematopoietic Niche Function
The authors investigated targetable cellular and molecular abnormalities in leukemia marrow stroma responsible for the suppression of normal hematopoiesis using a T-ALL mouse model and human T-ALL xenografts. [Cancer Res] Abstract

High Expression of Connective Tissue Growth Factor Accelerates Dissemination of Leukemia
Researchers genetically engineered leukemia cells to modulate connective tissue growth factor (CTGF) expression levels. Elevated CTGF levels accelerated disease dissemination and reduced survival in NOD/SCID mice. [Oncogene] Abstract

Single-Cell RNA-Sequencing Reveals a Continuous Spectrum of Differentiation in Hematopoietic Cells
Investigators applied single-cell RNA-sequencing to a population of hematopoietic cells in zebrafish as they undergo thrombocyte lineage commitment. [Cell Rep] Full Article | Graphical Abstract

RUNX1B Expression Is Highly Heterogeneous and Distinguishes Megakaryocytic and Erythroid Lineage Fate in Adult Mouse Hematopoiesis
Runx1 has two promoters P1 (distal) and P2 (proximal), which generate distinct protein isoforms. Utilizing a dual reporter mouse model, researchers demonstrated that the distal P1 promoter is broadly active in adult hematopoietic stem and progenitor cell populations. [PLoS Genet] Full Article

H2AX Deficiency Is Associated with Erythroid Dysplasia and Compromised Hematopoietic Stem Cell Function
The authors used a genetically modified mouse model and human patient data to examine the physiological roles of H2AX in hematopoiesis and how the loss of H2AX contributes to dyserythropoiesis in myelodysplastic syndromes. [Sci Rep] Full Article

CLINICAL RESEARCH

TP53 Mutation in Patients with High-Risk Acute Myeloid Leukemia Treated with Allogeneic Hematopoietic Stem Cell Transplantation
Investigators studied the impact of TP53 mutations on the outcome of acute myeloid leukemia patients with adverse cytogenetic risk treated with allogeneic hematopoietic stem cell transplantation. [Br J Haematol] Abstract

TCR-Alpha/Beta and CD19 Depletion and Treosulfan-Based Conditioning Regimen in Unrelated and Haploidentical Transplantation in Children with Acute Myeloid Leukemia
The authors evaluated the depletion of TCR-alpha/beta cells from the graft of children with high-risk AML, who received transplantation from unrelated and haploidentical donors. [Bone Marrow Transplant] Abstract

Comparable Outcomes between Autologous and Allogeneic Transplant for Adult Acute Myeloid Leukemia in First CR
Investigators retrospectively compared the outcomes of patients who underwent autologous peripheral blood stem cell transplantation (PBSCT) with those who underwent allogeneic bone marrow transplantation and allogeneic-PBSCT from HLA-matched sibling donor for adults with acute myeloid leukemia/CR1. [Bone Marrow Transplant] Abstract

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REVIEWS
Hematopoietic Stem/Progenitor Cell Commitment to the Megakaryocyte Lineage
The authors discuss the evidence supporting non-classical megakaryocytic differentiation pathways and consider their relative strengths and weaknesses as well as the technical limitations and potential pitfalls in interpreting these studies. [Blood] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.
 
INDUSTRY NEWS
AbbVie’s Venetoclax Receives Breakthrough Therapy Designation from FDA in Combination with Rituximab for the Treatment of Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia
AbbVie announced that the U.S. Food and Drug Administration (FDA) granted breakthrough therapy designation for venetoclax in combination with rituximab for the treatment of patients with relapsed/refractory chronic lymphocytic leukemia. [AbbVie Inc.] Press Release

Cellectis Enters into New Agreement with CELLforCURE for the cGMP Manufacturing of UCART123 for Hematological Malignancies
Cellectis announced that it entered into a new agreement for the cGMP manufacturing of UCART123 clinical batches, Cellectis’ lead product candidate, with CELLforCURE. [Cellectis] Press Release

Regen BioPharma Submits Application to FDA for Orphan Drug Designation for its HemaXellerate Product
BioPharma, Inc. announced submission to the Food and Drug Administration (FDA) of an application requesting orphan drug status for the use of HemaXellerate for the treatment of aplastic anemia. [Regen BioPharma Inc. (PR Newswire Association LLC.)] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 24th Biennial European Association for Cancer Research (EACR) Congress
July 9-16, 2016
Manchester, United Kingdom

Visit our events page to see a complete list of events in the hematopoiesis community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Researcher – Pre-Leukemic Stem Cells in the Thymus (Ghent University)

Research Fellow/Research Officer – Zeb2 Transcription Factor in Hematopoietic Stem Cell Differentiation (Monash University)

Laboratory Technician – Molecular Biology (Icahn School of Medicine at Mount Sinai)

Postdoctoral Fellow – Stem Cell Biology (Krembil Research Institute)

Postdoctoral Scholarship – Cancer Biology (Lund University)

Science Content Writer (Howard Hughes Medical Institute)

Postdoctoral Fellowship – Tumor Immunology and Cancer Metabolism (Yale University)

Research Specialist – Stem Cells from the Hematopoietic System (Howard Hughes Medical Institute)

Postdoctoral Fellow – Leukemia Biology (Fred Hutchinson Cancer Research Center)

Postdoctoral Position – Epigenetics and RNA Splicing (National Cancer Institute)

Postdoctoral position – Regenerative Medicine (University of Copenhagen)

Assistant/Associate/Full Member Faculty – Myeloid Malignancies (Fred Hutchinson Cancer Research Center)


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