Volume 7.02 | Jan 19

Hematopoiesis News 7.02 January 19, 2016
Hematopoiesis News
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Repression of p53-Target Gene Bbc3/PUMA by MYSM1 Is Essential for the Survival of Hematopoietic Multipotent Progenitors and Contributes to Stem Cell Maintenance
Scientists showed the transcriptional activation of p53 stress responses in Mysm1-/- hematopoietic stem and progenitor cells. Mechanistically, they found that the MYSM1 protein associates with p53 and colocalizes to promoters of classical p53-target genes Bbc3/PUMA (p53 upregulated modulator of apoptosis) and Cdkn1a/p21. [Cell Death Differ] Full Article
Learn more about STEMvision automated mouse hematopoietic colony-forming unit (CFU) assay imaging and counting.
PUBLICATIONS (Ranked by impact factor of the journal)
Stable Multilineage Xenogeneic Replacement of Definitive Hematopoiesis in Adult Zebrafish
Investigators used a zebrafish strain lacking definitive hematopoiesis for interspecific analysis of hematopoietic cell development. Without conditioning prior to transplantation, hematopoietic progenitor cells from goldfish stably engraft in adult zebrafish homozygous for the c-mybI181N mutation. [Sci Rep] Full Article

Co-Cultured hBMSCs and HUVECs on Human Bio-Derived Bone Scaffolds Provide Support for the Long-Term Ex Vivo Culture of HSC/HPCs
In order to closely mimic a multi-cell state in hematopoietic stem/progenitor cells (HSC/HPCs) vascular niche, researchers co-cultured human bone marrow mesenchymal stem cells (hBMSCs) and human umbilical vein endothelial cells (HUVECs) without any cytokines as feeder cells and applied bio-derived bone from human femoral metaphyseal portion as scaffold to develop a new HSC/HPCs three-dimensional culture system. [J Biomed Mater Res A] Abstract

In Vitro and In Vivo Evaluation of Cord Blood Hematopoietic Stem and Progenitor Cells Amplified with Glycosaminoglycan Mimetic
Because glycosaminoglycans (GAGs) are known to be important components of the hematopoietic niche and to modulate growth factor effects, investigators explored the use of GAG mimetic OTR4131 to potentiate hematopoietic stem cells and progenitor cells in vitro expansion and in vivo engraftment. [Stem Cell Res Ther] Full Article

Increased Engraftment of Human Short Term Repopulating Hematopoietic Cells in NOD/SCID/IL2rγnull Mice by Lentiviral Expression of NUP98-HOXA10HD
Researchers evaluated whether NUP98-HOXA10HD could be used to expand engrafting human primitive CD34+ cells in an immunodeficient mouse model. [PLoS One] Full Article

Reprogramming of Human Peripheral Blood Monocytes to Erythroid Lineage by Blocking of the PU-1 Gene Expression
To demonstrate whether PU.1 suppression induces monocyte lineage conversion into red blood cells, a combination of three PU.1-specific siRNAs was implemented to knock down PU.1 gene expression and generate the balance in favor of GATA-1 expression to induce erythroid differentiation. [Ann Hematol] Abstract

ESAM Is a Novel Human Hematopoietic Stem Cell Marker Associated with a Subset of Human Leukemias
Researchers found that endothelial cell-selective adhesion molecule (ESAM) can also be used to purify human hematopoietic stem cells from all the currently available sources (adult bone marrow, mobilized peripheral blood, and cord blood). [Exp Hematol] Abstract

Ezh2 Regulates the Lin28/let-7 Pathway to Restrict Activation of Fetal Gene Signature in Adult Hematopoietic Stem Cells
Scientists showed that in the absence of the polycomb-group gene Ezh2, a cohort of fetal-specific genes, including let-7 target genes, were activated in bone marrow (BM) hematopoietic stem and progenitor cells (HSPCs), leading to acquisition of fetal phenotypes by BM HSPCs, such as enhanced self-renewal activity and production of fetal-type lymphocytes. [Exp Hematol] Abstract


Global Use of Peripheral Blood vs Bone Marrow as Source of Stem Cells for Allogeneic Transplantation in Patients with Bone Marrow Failure
The authors used international survey and transplant registry data to compare use of bone marrow with use of peripheral blood stem cells for hematopoietic stem cell transplantation in World Health Organization member countries. [JAMA] Abstract | Press Release

Analysis of Non-Relapse Mortality and Causes of Death over 15 Years following Allogeneic Hematopoietic Stem Cell Transplantation
Investigators performed a retrospective single-center study to assess changes in outcomes after allogeneic hematopoietic stem cell transplantation and causes of non-relapse mortality over three five year periods. [Bone Marrow Transplant] Abstract

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The Functional Relationship between Hematopoietic Stem Cells and Developing T Lymphocytes
The authors review the process of thymic seeding by bone marrow-derived cells and T cell commitment in humans, discussing recent insights into the clonal composition of the thymus and the definition of developmental checkpoints, on the basis of insights from human severe combined immunodeficiency patients. [Ann N Y Acad Sci] Abstract

Hematopoietic Stem Cell Transplantation for Multiple Sclerosis: Is It a Clinical Reality?
The authors discuss the rationale of hematopoietic stem cell transplantation to treat multiple sclerosis by providing the benefits and complications of the clinically relevant protocols, the varying graft types, and conditioning regimens. [Stem Cell Res Ther] Full Article

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.
Geron Announces Initiation of Janssen Phase II/III Clinical Trial of Imetelstat in Myelodysplastic Syndromes
Geron Corporation announced the dosing of the first patient in a Phase II/III clinical trial to evaluate imetelstat in patients with myelodysplastic syndromes. This clinical trial, also referred to as the IMerge™ study, is being conducted by Janssen Research & Development, LLC, and is the second study to be initiated under the terms of the exclusive worldwide imetelstat license and collaboration agreement between Geron and Janssen Biotech, Inc. [Geron™] Press Release

$5 Million Donation from the Hospira Foundation Will Support Research in Cancer Care, Prevention and Treatment
The Hospira Foundation has donated $5 million to the University of Chicago Medicine to create the Hospira Foundation Professorship in Oncology. This position significantly bolsters the University’s capacity to conduct pioneering research in cancer. [The Hospira Foundation (Newswise, Inc.)] Press Release

From our sponsor: Learn about applications of ALDHbr cells in regenerative medicine. Watch the video.
National Institutes of Health (United States)

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Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW The Controlling Cancer Summit 2016
May 17-19, 2016
London, United Kingdom

Visit our events page to see a complete list of events in the hematopoiesis community.
NEW Research Fellow/Research Officer – Zeb2 Transcription Factor in Hematopoietic Stem Cell Differentiation (Monash University)

Laboratory Technician – Molecular Biology (Icahn School of Medicine at Mount Sinai)

Postdoctoral Fellow – Stem Cell Biology (Krembil Research Institute)

Postdoctoral Scholarship – Cancer Biology (Lund University)

Science Content Writer (Howard Hughes Medical Institute)

Postdoctoral Fellowship – Tumor Immunology and Cancer Metabolism (Yale University)

Research Specialist – Stem Cells from the Hematopoietic System (Howard Hughes Medical Institute)

Postdoctoral Fellow – Leukemia Biology (Fred Hutchinson Cancer Research Center)

Postdoctoral Position – Epigenetics and RNA Splicing (National Cancer Institute)

Postdoctoral position – Regenerative Medicine (University of Copenhagen)

Assistant/Associate/Full Member Faculty – Myeloid Malignancies (Fred Hutchinson Cancer Research Center)

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