Volume 6.48 | Dec 8

Hematopoiesis News 6.48 December 8, 2015
Hematopoiesis News
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Fetal Liver Hematopoietic Stem Cell Niches Associate with Portal Vessels
Scientists showed that Nestin+NG2+ pericytes associate with portal vessels, forming a niche promoting hematopoietic stem cell (HSC) expansion. Nestin+NG2+ cells and HSCs scale during development with the fractal branching patterns of portal vessels, tributaries of the umbilical vein. [Science] Abstract
Learn more about STEMvision automated mouse hematopoietic colony-forming unit (CFU) assay imaging and counting.
PUBLICATIONS (Ranked by impact factor of the journal)
GFI1 Proteins Orchestrate the Emergence of Hematopoietic Stem Cells through Recruitment of LSD1
The authors demonstrated that Gfi1 (growth factor independence 1) expression specifically defines the rare population of hemogenic endothelium that generates emerging hematopoietic stem cells (HSCs). They further established that in the absence of GFI1 proteins, HSCs and hematopoietic progenitor cells are not produced in the aorta–gonad–mesonephros. [Nat Cell Biol] Abstract

SF3B1 Mutant MDS-Initiating Cells May Arise from the Hematopoietic Stem Cell Compartment
Scientists demonstrated that SF3B1 mutation(s) in a cohort of myelodysplastic syndrome (MDS) patients with ring sideroblasts can arise from CD34+CD38CD45RACD90+CD49f+ hematopoietic stem cells and is an initiating event in disease pathogenesis. [Nat Commun] Full Article

Targeting Acute Myeloid Leukemia with a Small Molecule Inhibitor of the Myb/p300 Interaction
Investigators demonstrated that celastrol suppresses the proliferative potential of acute myeloid leukemia cells while not affecting normal hematopoietic progenitor cells. [Blood] Abstract

MTSS1 Is a Critical Epigenetically Regulated Tumor Suppressor in CML
Scientists identified metastasis suppressor 1 (Mtss1/MIM) to be downregulated in hematopoietic stem and progenitor cells from leukemic transgenic SCLtTA/Bcr-Abl mice and in patients with chronic myeloid leukemia (CML) at diagnosis, and Mtss1 was restored when patients achieved complete remission. [Leukemia] Abstract

Identification of CD25 as STAT5-Dependent Growth-Regulator of Leukemic Stem Cells in Ph+ CML
In contrast to normal hematopoietic stem cells, CD34+/CD38 chronic myeloid leukemia (CML) leukemic stem cells expressed the interleukin-2 receptor alpha chain, IL-2RA (CD25). STAT5 was found to induce expression of CD25 in Lin/Sca1+/Kit+ stem cells in C57Bl/6 mice [Clin Cancer Res] Abstract

The Ribosome Biogenesis Protein Nol9 Is Essential for Definitive Hematopoiesis and Pancreas Morphogenesis in Zebrafish
Researchers describe a zebrafish mutant with a loss-of-function mutation in nol9. The nol9sa1022/sa1022 larvae displayed hypoplastic pancreas, liver and intestine and had decreased numbers of hematopoietic stem and progenitor cells. [PLoS Genet] Full Article


Rapid Expansion of Pre-Existing Non-Leukemic Hematopoietic Clones Frequently Follows Induction Therapy for De Novo AML
Investigators report that five of 15 patients with genetic clearance of their founding acute myelogenous leukemia (AML) clone after induction chemotherapy had a concomitant expansion of a hematopoietic population unrelated to the initial AML. [Blood] Abstract

Does Ex Vivo CD34+ Positive Selection Influence Outcome after Autologous Hematopoietic Stem Cell Transplantation in Systemic Sclerosis Patients?
Scientists demonstrated that CD34+ does not add benefit to the outcome of systemic sclerosis patient treated with autologous hematopoietic stem cell transplantation. [Bone Marrow Transplant] Abstract

Outcome of Second Allogeneic HCT following Relapse of Myeloid Malignancies Post Allogeneic HCT, a Retrospective Cohort on Behalf of the GETH
Researchers present a retrospective cohort of 116 patients diagnosed with acute myeloid leukemia, myelodysplastic syndromes and myeloproliferative disorders who consecutively underwent a second allogeneic stem cell transplantation (HCT) for disease relapse. [Biol Blood Marrow Transplant] Abstract

SmartDish™ with STEMgrid™-6 for Accurate Counting of Hematopoietic CFU Assays
Plasmacytoid Dendritic Cells in Allogeneic Hematopoietic Cell Transplantation: Benefit or Burden?
The authors review the pre-clinical and clinical literature, supporting the crucial roles that plasmacytoid dendritic cells assume as key immune effector cells during hematopoietic cell transplantation. [Bone Marrow Transplant] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.
Novartis Announces New CTL019 Study Data Demonstrating Overall Response in Adult Patients with Certain Types of Lymphoma
Findings from an ongoing Phase IIa study to evaluate the safety and efficacy of investigational chimeric antigen receptor T cell therapy CTL019 in certain types of relapsed or refractory non-Hodgkin lymphoma were presented. [Press release from Novartis AG discussing research presented at the 57th American Society of Hematology (ASH) Annual Meeting, Orlando] Press Release

Amgen Presents Data from Three Trials Evaluating BLINCYTO® (Blinatumomab) In Acute Lymphoblastic Leukemia
Amgen announced that new data from three Phase II trials support the efficacy and safety of BLINCYTO® in adults with acute lymphoblastic leukemia. [Press release from Amgen, Inc. discussing research presented at the 57th American Society of Hematology (ASH) Annual Meeting, Orlando] Press Release

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Amgen And Merck Announce Cancer Immunotherapy Collaboration for Patients with Non-Hodgkin Lymphoma
Amgen and Merck announced a cancer immunotherapy collaboration to support a Phase Ib/III study investigating BLINCYTO® (blinatumomab) in combination with KEYTRUDA® (pembrolizumab) in patients with diffuse large B-cell lymphoma. [Amgen Inc.] Press Release

Teva Pharmaceuticals and Eagle Pharmaceuticals Announce FDA Approval of BENDEKA™ (Bendamustine Hydrochloride) Injection
Teva Pharmaceutical Industries Ltd. and Eagle Pharmaceuticals, Inc. announced that the U.S. Food and Drug Administration has approved BENDEKA™ injection. BENDEKA is approved for the treatment of patients with chronic lymphocytic leukemia and for the treatment of patients with indolent B-cell non-Hodgkin lymphoma that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. [Teva Pharmaceutical Industries Ltd.] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 10th International Congress on Autoimmunity
April 6-10, 2016
Leipzig, Germany

Visit our events page to see a complete list of events in the hematopoiesis community.
NEW Full Member Faculty – Hematopoietic Cell Transplant Program (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Leukemia and Lymphoma (Emory University)

Assistant/Associate/Full Member Faculty – Myeloid Malignancies (Fred Hutchinson Cancer Research Center)

Team Leader/Professor/Associate Professor – Regenerative Medicine (Ji Nan University)

Postdoctoral Researcher – Cardiovascular/Hematopoietic Development (Kumamoto University)

Postdoctoral Fellow – Leukemia Research (City of Hope)

Postdoctoral Position – Stem Cells and Leukemia (Florida State University)

Assistant or Associate Professor – Cell and Regenerative Biology (University of Wisconsin, Madison)

Postdoctoral Research Fellow – Medicinal Chemistry for Cancer Drug Discovery (University of Michigan)

Postdoctoral Fellow – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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