Volume 6.44 | Nov 10

Hematopoiesis News 6.44 November 10, 2015
Hematopoiesis News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Stem-Cell Scientists Redefine How Blood Is Made, Toppling Conventional ‘Textbook’ View from 1960s
Scientists resolved how different kinds of blood cells form quickly from the stem cell — the most potent blood cell in the system — and not further downstream as has been traditionally thought. [Press release from University Health Network discussing online prepublication in Science] Press Release | Abstract
Enter now to win a $500 travel award to attend the Annual American Society for Hematology (ASH) Meeting in Orlando, Florida!
 
PUBLICATIONS (Ranked by impact factor of the journal)
Homology-Driven Genome Editing in Hematopoietic Stem and Progenitor Cells Using ZFN mRNA and AAV6 Donors
Scientists report that combining electroporation of zinc finger nuclease (ZFN) mRNA with donor template delivery by adeno-associated virus (AAV) serotype 6 vectors directs efficient genome editing in hematopoietic stem and progenitor cells. [Nat Biotechnol] Abstract | Press Release

Low-Cell-Number Epigenome Profiling Aids the Study of Lens Aging and Hematopoiesis
Recovery via protection-chromatin-immunoprecipitation-based deep sequencing (RP-ChIP-seq) allowed detection of age-associated epigenetic changes in a single mouse lens, whereas favored amplification RP-ChIP-seq accurately mapped histone H3 lysine 4 trimethylation (H3K4me3) and H3K27me3 in long-term hematopoietic stem cells (HSCs), short-term HSCs, and multi-potent progenitors from one mouse. [Cell Rep] Full Article | Graphical Abstract

UFBP1, a Key Component of the Ufm1 Conjugation System, Is Essential for Ufmylation-Mediated Regulation of Erythroid Development
Researchers report that UFBP1 (Ufm1 binding protein 1) is indispensable for embryonic development and hematopoiesis. [PLoS Genet] Full Article

The Role of CD44 in Fetal and Adult Hematopoietic Stem Cell Regulation
CD44 expression and function were assessed and characterized on both fetal and adult hematopoietic stem cells. [Haematologica] Abstract | Full Article

ZFP36L1 Promotes Monocyte/Macrophage Differentiation by Repressing CDK6
Investigators identified that ZFP36L1 exhibits significant decrease in acute myeloid leukemia patients compared with normal controls and remarkable time-course increase during monocyte/macrophage differentiation of PMA-induced THP-1 and HL-60 cells as well as induction culture of CD34+ hematopoietic stem/progenitor cells. [Sci Rep] Full Article

DNA-Methylation in C1R Is a Prognostic Biomarker for Acute Myeloid Leukemia
Analysis of DNA-methylation at complement component 1 subcomponent R (C1R) provided a simple, robust, and cost-effective biomarker to further complement risk assessment in acute myeloid leukemia. [Clin Epigenetics] Full Article

Identification of a Hematopoietic Cell Dedifferentiation-Inducing Factor
Researchers found that using a conditioned medium from proliferating fibroblasts can induce a subset of hematopoietic cells to become adherent fibroblast-like cells. [J Cell Physiol] Abstract

CLINICAL RESEARCH

Phase II Study of Allogeneic Transplantation for Older Patients with Acute Myeloid Leukemia in First Complete Remission Using a Reduced-Intensity Conditioning Regimen: Results from Cancer and Leukemia Group B 100103 (Alliance for Clinical Trials in Oncology)/Blood and Marrow Transplant Clinical Trial Network 0502
The authors prospectively determined the value of hematopoietic stem-cell transplantation for older patients with acute myeloid leukemia in first complete remission. [J Clin Oncol] Full Article | Press Release

T-Replete Haploidentical Allogeneic Transplantation Using Post-Transplantation Cyclophosphamide in Advanced AML and Myelodysplastic Syndromes
Scientists analyzed 60 consecutive patients with refractory or high-risk CR AML or myelodysplastic syndromes who underwent post-transplantation cyclophosphamide haplo-transplantation. [Bone Marrow Transplant] Abstract

Learn more about STEMvision automated mouse hematopoietic colony-forming unit (CFU) assay imaging and counting.
 
REVIEWS
Mechanisms of Fate Decision and Lineage Commitment during Hematopoiesis
The authors review recent single cell studies in the hematopoietic system and their contribution to our understanding of the mechanisms governing cell fate choices and lineage commitment [Immunol Cell Biol] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

Register for the CAR-T Summit 2015!
 
INDUSTRY NEWS
British Cancer Scientist Wins Lifetime Achievement Award
Cancer biologist Professor Mel Greaves has been awarded the Cancer Research UK Lifetime Achievement Award for his work investigating the causes of childhood leukemia. [Cancer Research UK] Press Release

NIH Awards City of Hope $2.2 Million Grant for Study of Chronic Graft-versus-Host Disease
The National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIH) has awarded a $2.2 million grant to help City of Hope researchers explore the underlying mechanisms of graft-versus-host disease, the leading cause of long-term sickness and death following transplantation of bone marrow cells from a donor. [City of Hope (Business Wire)] Press Release

From our sponsor: Learn about applications of ALDHbr cells in regenerative medicine. Watch the video.
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW German Cancer Congress 2016
February 24-27, 2016
Berlin, Germany

Visit our events page to see a complete list of events in the hematopoiesis community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Researcher – Cardiovascular/Hematopoietic Development (Kumamoto University)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Leukemia Research (City of Hope)

Postdoctoral Position – Stem Cells and Leukemia (Florida State University)

PhD Studentships – Cancer Research (Cancer Research UK Manchester Institute)

Assistant or Associate Professor – Cell and Regenerative Biology (University of Wisconsin, Madison)

Postdoctoral Research Fellow – Medicinal Chemistry for Cancer Drug Discovery (University of Michigan)

Research Technician – Stem Cell and Gene Therapy (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – iPSC Models of Hematologic Disorders (Icahn School of Medicine at Mount Sinai)

Postdoctoral Fellow – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

Postdoctoral Positions – Cancer and Developmental Biology (North Carolina Central University)

Assistant Professor – Stem Cell Biology (University of South Carolina)


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