Volume 6.37 | Sep 22

Hematopoiesis News 6.37 September 22, 2015
Hematopoiesis News
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CD93 Marks a Non-Quiescent Human Leukemia Stem Cell Population and Is Required for Development of MLL-Rearranged Acute Myeloid Leukemia
Scientists showed that acute myeloid leukemias (AMLs) with genomic rearrangements of the MLL gene contain a non-quiescent leukemia stem cell (LSC) population. Although human CD34+CD38 LSCs are generally highly quiescent, the C-type lectin CD93 was expressed on a subset of actively cycling, non-quiescent AML cells enriched for LSC activity. [Cell Stem Cell] Abstract | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation
Researchers showed that p53 activity is inhibited in inv(16)+ acute myeloid leukemia stem cells via interactions with the CBFβ-SMMHC fusion protein and histone deacetylase 8 (HDAC8). [Cell Stem Cell] Abstract | Graphical Abstract

Single-Cell Transcriptomic Reconstruction Reveals Cell Cycle and Multi-Lineage Differentiation Defects in Bcl11a-Deficient Hematopoietic Stem Cells
Investigators employed single-cell transcriptomic analysis to dissect the molecular heterogeneities in hematopoietic stem cells (HSCs). Analysis of lineage gene expression suggests that the Bcl11a-/- HSCs are constituted of two distinct myeloerythroid-restricted subpopulations. [Genome Biol] Full Article

Hematopoietic Stem Cells Develop in the Absence of Endothelial Cadherin 5 Expression
Utilizing time-lapse confocal imaging, parabiotic surgical pairing of zebrafish embryos, and blastula transplantation assays, researchers showed that hematopoietic stem cells emerge, migrate, engraft, and differentiate in the absence of cadherin 5 expression. [Blood] Abstract

ATF4 Plays a Pivotal Role in the Development of Functional Hematopoietic Stem Cells in Mouse Fetal Liver
Investigators demonstrated that deletion of activating transcription factor 4 (ATF4) significantly impaired hematopoietic development and reduced hematopoietic stem cell self-renewal in fetal liver. [Blood] Abstract

Functional Niche Competition Between Normal Hematopoietic Stem and Progenitor Cells and Myeloid Leukemia Cells
Scientists used the MLL-AF9 murine acute myeloid leukemia in a competitive repopulation model to investigate whether normal hematopoietic stem and progenitor cells and leukemic cells functionally compete for the same marrow niches. [Stem Cells] Abstract

Embryonic Hematopoietic Progenitor Cells Reside in Muscle before Bone Marrow Hematopoiesis
Researchers demonstrated that hematopoietic progenitor cell homing occurs earlier than previously reported and that hematopoietic progenitor cells reside in muscle tissue before bone marrow hematopoiesis occurs during mouse embryogenesis. [PLoS One] Full Article

Integration of Shh and Wnt Signaling Pathways Regulating Hematopoiesis
Researchers investigated the spatial and temporal programmed expression of Shh and Wnt members during key stages of definitive hematopoiesis and the possible mechanism of Shh and Wnt signaling pathways regulating the proliferation of hematopoietic progenitor cells. [DNA Cell Biol] Abstract


Impact of MRD and TKI on Allogeneic Hematopoietic Cell Transplantation for Ph+ALL: A Study from the Adult ALL WG of the JSHCT
The authors retrospectively analyzed data from a registry database for 432 adult Ph-positive ALL (Ph+ALL) patients in first CR who received pre-transplant tyrosine kinase inhibitor administration. [Bone Marrow Transplant] Abstract

Should Busulfan Therapeutic Range Be Narrowed in Pediatrics? Experience from a Large Cohort of Hematopoietic Stem Cell Transplant Children
Researchers investigated the relevance of using a more restricted therapeutic range and investigated the association between busulfan therapeutic range and clinical outcome. [Bone Marrow Transplant] Abstract

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Exosome-Mediated Microenvironment Dysregulation in Leukemia
The authors summarize recent works that decipher the normal hematopoietic niche cellular components and describe how the leukemia-transformed niche contributes to hematological malignances. [Biochim Biophys Acta] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

Register now for AABB Annual Meeting 2015!
Thomas Jefferson University Hospital and GenomOncology Codeveloping Multi-assay Integrated Cancer Profiling System
GenomOncology and Thomas Jefferson University Hospital announced that they are co-developing an interpretation and reporting system for multi-assay cancer profiling. Jefferson expects to launch the system for testing acute myeloid leukemia in their molecular pathology laboratory. [GenomOncology LLC.] Press Release

FDA Grants Priority Review for Amgen’s Supplemental New Drug Application for Expanded Labeling of Kyprolis® (Carfilzomib) in Relapsed Multiple Myeloma
Amgen announced the U.S. Food and Drug Administration (FDA) has accepted for priority review the supplemental new drug application (sNDA) of Kyprolis® (carfilzomib) for injection for patients with relapsed multiple myeloma. The sNDA is designed to expand the current indication to include Kyprolis in combination with dexamethasone for patients who have received at least one prior therapy. [Amgen] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 57th ASH Annual Meeting & Exposition
December 5-8, 2015
Orlando, Florida

Visit our events page to see a complete list of events in the hematopoiesis community.
NEW Assistant Professor – Stem Cell Biology (University of South Carolina)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Postdoctoral Position – Hematology and Immunology (University of Liege)

Director of Research – Oncology and Hematology (CancerCare Manitoba)

Postdoctoral Fellow – HMGA Chromatin Remodeling Proteins in Cancer and Stem Cell Biology (Johns Hopkins University School of Medicine)

Regulatory Coordinator – Leukemia (Fred Hutchinson Cancer Research Center)

Postdoctoral Position – Hematologic Malignancies (Northwestern University)

Postdoctoral Fellow – Hematopoietic Regeneration and Myeloid Malignancies (Weill-Cornell Medical College)

Postdoctoral Position – Hematopoietic Stem and Progenitor Cell Assays (Weill Cornell Medical School)

Research Associate – Cell Biology (Editas Medicine)

Clinical Research Coordinator – Chronic Lymphocytic Leukemia (Fred Hutchinson Cancer Research Center)

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