Volume 6.33 | Aug 25

Hematopoiesis News 6.33 August 25, 2015
Hematopoiesis News
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Emergency Program Ensures Blood Coagulation
Scientists have now discovered an emergency program in mice that bypasses the known pathway of blood stem cell differentiation so that the vital thrombocytes are rapidly replenished. They discovered, within the hematopoietic stem cells, a small cell population that is defined molecularly to induce differentiation of megakaryocytes, the progenitors of platelets. [Press release from DKFZ discussing online prepublication in Cell Stem Cell] Press Release | Abstract | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Kindlin-3-Mediated Integrin Adhesion Is Dispensable for Quiescent but Essential for Activated Hematopoietic Stem Cells
Scientists report that Kindlin-3-mediated integrin activation controls homing of hematopoietic stem cells (HSCs) to the bone marrow (BM) and the retention of activated HSCs and hematopoietic progenitor cells but not of quiescent HSCs in their BM niches. [J Exp Med] Abstract

Dipeptide Species Regulate p38MAPK-Smad3 Signaling to Maintain Chronic Myelogenous Leukemia Stem Cells
The authors surveyed global metabolic differences between murine normal hematopoietic stem cells (HSCs) and chronic myelogenous leukemia (CML) stem cells using metabolomics techniques. They showed that CML stem cells accumulate significantly higher levels of certain dipeptide species than normal HSCs. [Nat Commun] Full Article

FOXF1 Inhibits Hematopoietic Lineage Commitment during Early Mesoderm Specification
Researchers revealed that FOXF1-expressing mesoderm was derived from FLK1+ progenitors and that in vitro this transcription factor was expressed in smooth muscle and transiently in endothelial lineages but not in hematopoietic cells. [Development] Abstract

Targeting BTK for the Treatment of FLT3-ITD Mutated Acute Myeloid Leukemia
Researchers placed the FMS-like-tyrosine-kinase-3 (FLT3)-ITD upstream of Bruton’s tyrosine kinase (BTK) in acute myeloid leukemia (AML) and showed that the BTK inhibitor ibrutinib inhibited the survival and proliferation of FLT3-ITD primary AML blasts and AML cell lines. [Sci Rep] Full Article

Salarin C Inhibits Maintenance of Hypoxia-Selected Chronic Myeloid Leukemia Progenitor Cells
Salarin C, an anticancer macrolide extracted from the Fascaplysinopsis sponge, was tested for its activity on chronic myeloid leukemia cells, especially after their incubation in atmosphere at 0.1% oxygen. Salarin C induced mitotic cycle arrest, apoptosis and DNA damage. [Cell Cycle] Abstract

Olive Leaf Components Apigenin 7-Glucoside and Luteolin 7-Glucoside Direct Human Hematopoietic Stem Cell Differentiation towards Erythroid Lineage
Main olive leaf phytochemicals oleuropein, apigenin 7-glucoside and luteolin 7-glucoside were investigated for their potential effects on hematopoietic stem cell differentiation using both phenotypic and molecular analysis. [Differentiation] Abstract

Loss of the Homeodomain Transcription Factor Prep1 Perturbs Adult Hematopoiesis in the Bone Marrow
Scientists generated hematopoietic- and endothelial cell-specific Prep1-deficient mice and demonstrated that expression of Prep1 in the hematopoietic cell compartment is not essential for either embryonic or adult hematopoiesis, although its absence caused significant hematopoietic abnormalities in the adult bone marrow. [PLoS One] Full Article


Contribution of Chemotherapy Mobilization to Disease Control in Multiple Myeloma Treated with Autologous Hematopoietic Cell Transplantation
In patients with multiple myeloma (MM) undergoing autologous hematopoietic cell transplantation (auto-HCT), peripheral blood progenitor cells may be collected following mobilization with growth factor alone (GF) or cytotoxic chemotherapy plus GF (CC+GF). Investigators compared these mobilization strategies in a retrospective analysis of 968 patients with MM from the Center for International Blood and Marrow Transplant Research database who received an auto-HCT in the US and Canada between 2007 and 2012. [Bone Marrow Transplant] Abstract

Numerical Impairment of Nestin+ Bone Marrow Niches in Acute GvHD after Allogeneic Hematopoietic Stem Cell Transplantation for AML
To investigate whether acute GvHD reduces the number of nestin+ perivascular bone marrow stem cell niches, researchers examined patients with AML who had undergone allogeneic hematopoietic stem cell transplantation. [Bone Marrow Transplant] Abstract

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Autologous Stem Cell Transplantation for Adult Acute Leukemia in 2015: Time to Rethink? Present Status and Future Prospects
The use of autologous stem cell transplantation as consolidation therapy for adult patients with acute leukemia has declined over time. However, multiple randomized studies in the past have reported lower relapse rates after autologous transplantation compared with chemotherapy and lower non-relapse mortality rates compared with allogeneic transplantation. [Bone Marrow Transplant] Abstract

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IBC’s Cell Therapy Bioprocessing & Commercialization meeting
$52 Million NIH Grant Advances Clinical and Translational Research at UC San Diego
The Clinical and Translational Research Institute at University of California, San Diego has received a five-year Clinical and Translational Science Award for approximately $52 million from the National Center for Advancing Translational Science, part of the National Institutes of Health (NIH). [UC San Diego Health] Press Release

NYBC Partners with UC Davis Health System to Produce More Viable Stem Cell Therapies
New York Blood Center (NYBC) announced a new collaboration with the University of California, Davis, Health System to manufacture specialized lines of stem cells as potential therapies for repair and regeneration of retina, kidney, lung and liver tissue, as well as for the treatment of neurodegenerative disorders such as Parkinson’s, Alzheimer’s and Huntington’s disease. [New York Blood Center] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW War on Cancer 2015
October 20, 2015
London, United Kingdom

Visit our events page to see a complete list of events in the hematopoiesis community.
NEW Postdoctoral Fellow – HMGA Chromatin Remodeling Proteins in Cancer and Stem Cell Biology (Johns Hopkins University School of Medicine)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Regulatory Coordinator – Leukemia (Fred Hutchinson Cancer Research Center)

Postdoctoral Position – Hematologic Malignancies (Northwestern University)

Postdoctoral Research Associate – Pharmacogenomics (St. Jude Children’s Research Hospital)

Postdoctoral Fellow – Hematopoiesis (University Hospital of Cologne)

Postdoctoral Fellow – Hematopoietic Regeneration and Myeloid Malignancies (Weill-Cornell Medical College)

Postdoctoral Position – Hematopoietic Stem and Progenitor Cell Assays (Weill Cornell Medical School)

Research Associate – Cell Biology (Editas Medicine)

Clinical Research Coordinator – Chronic Lymphocytic Leukemia (Fred Hutchinson Cancer Research Center)

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