Volume 6.32 | Aug 18

Hematopoiesis News 6.32 August 18, 2015
Hematopoiesis News
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A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression
Scientists showed that T-cell immunoglobin mucin-3 (TIM-3) and its ligand, galectin-9 (Gal9), constitute an autocrine loop critical for leukemic stem cells self-renewal and development of human acute myeloid leukemia. [Cell Stem Cell] Abstract | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
BMP Signaling Differentially Regulates Distinct Hematopoietic Stem Cell Types
Investigators showed that hematopoietic stem cells in murine fetal liver and the bone marrow are of two types that can be prospectively isolated—BMP activated and non-BMP activated. [Nat Commun] Full Article

The tRNA Methyltransferase Dnmt2 Is Required for Accurate Polypeptide Synthesis during Hematopoiesis
Scientists showed that endochondral ossification is delayed in newborn Dnmt2-deficient mice, which was accompanied by a reduction of the hematopoietic stem and progenitor cell population and a cell-autonomous defect in their differentiation. [EMBO J] Full Article | Graphical Abstract

Antibodies Targeting Human IL1RAP (IL1R3) Show Therapeutic Effects in Xenograft Models of Acute Myeloid Leukemia
The interleukin 1 receptor accessory protein (IL1RAP; IL1R3) is expressed on candidate leukemic stem cells in the majority of acute myeloid leukemia patients, but not on normal hematopoietic stem cells. Investigators showed that monoclonal antibodies targeting IL1RAP had strong antileukemic effects in xenograft models of human AML. [Proc Natl Acad Sci USA] Abstract | Full Article

Estrogen Deficiency Heterogeneously Affects Tissue Specific Stem Cells in Mice
Ovariectomy significantly increased the numbers of c-kit-positive hematopoietic stem/progenitor cells in bone marrow, but impaired their capacity to grow mixed cell-type colonies in vitro. [Sci Rep] Full Article

Hierarchal Autophagic Divergence of Hematopoietic System
Using conditional mouse models to create strategic defects in the hematopoietic hierarchy, the authors showed that recovery capacities in stem cells and somatic cells differed if autophagy is impaired or flawed. [J Biol Chem] Abstract | Full Article

Autophagy Limits Proliferation and Glycolytic Metabolism in Acute Myeloid Leukemia
Researchers demonstrated that loss of Atg5 resulted in an identical hematopoietic stem and progenitor cell (HSPC) phenotype as loss of Atg7, confirming a general role for autophagy in HSPC regulation. [Cell Death Disc] Full Article


Clofarabine Salvage Therapy Prior to Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Relapsed or Refractory AML
Researchers studied the safety and efficacy of clofarabine-based salvage therapy. The study was designed as a Phase II, multi-center, intent-to-transplant study. [Leukemia] Abstract

Allogeneic Hematopoietic Stem Cell Transplantation for Mitochondrial Neurogastrointestinal Encephalomyopathy
Investigators conducted a retrospective analysis of all known patients suffering from mitochondrial neurogastrointestinal encephalomyopathy who underwent allogeneic hematopoietic stem cell transplantation between 2005 and 2011. [Brain] Abstract

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The Role of Microenvironment and Immunity in Drug Response in Leukemia
The authors discuss the various ways that the microenvironment can contribute to the resistance and persistence of leukemia. [Biochim Biophys Acta] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.
Phase II Study of Venetoclax in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia with 17p Deletion Meets Primary Endpoint
AbbVie announced that a Phase II trial of its investigational medicine venetoclax met its primary endpoint of achieving overall response rates in patients with relapsed/refractory or previously untreated chronic lymphocytic leukemia with 17p deletion, according to an independent review analysis. [AbbView Inc.] Press Release

Sorrento Therapeutics and Its Wholly-Owned Subsidiary, TNK Therapeutics, to Exclusively License CytoLumina’s NanoVelcro Circulating Tumor Cell Profiling Assay
Sorrento Therapeutics, Inc. announced that it as well as its wholly-owned subsidiary TNK Therapeutics, Inc. have entered into a binding term sheet to exclusively license the NanoVelcro circulating tumor cell profiling assay technology from CytoLumina Technologies Corp. and FetoLumina Technologies Corp. [Sorrento Therapeutics, Inc.] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Society for Immunotherapy of Cancer (SITC) 2015
November 4-8, 2015
National Harbor, United States

Visit our events page to see a complete list of events in the hematopoiesis community.
NEW Postdoctoral Position – Hematologic Malignancies (Northwestern University)

NEW Regulatory Coordinator – Leukemia (Fred Hutchinson Cancer Research Center)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Research Associate – Pharmacogenomics (St. Jude Children’s Research Hospital)

Postdoctoral Fellow – Hematopoiesis (University Hospital of Cologne)

Postdoctoral Fellow – Hematopoietic Regeneration and Myeloid Malignancies (Weill-Cornell Medical College)

Postdoctoral Position – Hematopoietic Stem and Progenitor Cell Assays (Weill Cornell Medical School)

Research Associate – Cell Biology (Editas Medicine)

Clinical Research Coordinator – Chronic Lymphocytic Leukemia (Fred Hutchinson Cancer Research Center)

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