Volume 6.28 | Jul 21

Newsletter Issue
Hematopoiesis News 6.29 July 21, 2015
Hematopoiesis News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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The H3K4-Methyl Epigenome Regulates Leukemia Stem Cell Oncogenic Potential
Investigators report that leukemia stem cells (LSCs) in MLL-associated leukemia reside in an epigenetic state of relative genome-wide high-level H3K4me3 and low-level H3K79me2. LSC differentiation was associated with reversal of these broad epigenetic profiles, with concomitant downregulation of crucial MLL target genes and the LSC maintenance transcriptional program that was driven by the loss of H3K4me3, but not H3K79me2. [Cancer Cell] Abstract | Graphical Abstract
PUBLICATIONS (Ranked by impact factor of the journal)
Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Stress Resistance to Hematopoietic Stem and Progenitor Cells
Researchers showed that Runx1-deficient hematopoietic stem and progenitor cells have a slow growth, low biosynthetic, small cell phenotype and markedly reduced ribosome biogenesis. [Cell Stem Cell]
| Graphical Abstract

Leukemic Marrow Infiltration Reveals a Novel Role for Egr3 as a Potent Inhibitor of Normal Hematopoietic Stem Cell Proliferation
The authors used a robust non-irradiated mouse model of human MLL-AF9 leukemia to examine the suppression of hematopoietic stem cells (HSCs) and hematopoietic progenitor cells during leukemia cell expansion in vivo. Gene expression profiling and further functional validation revealed that Egr3 was a strong limiting factor for the proliferative potential of HSCs. [Blood] Abstract

Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2
Scientists showed that nitrogen permease regulator-like 2 (NPRL2) is required for mouse viability and that its absence significantly compromised fetal liver hematopoiesis in developing embryos. [Cell Rep]
Full Article | Graphical Abstract

Deficiency of the Ribosome Biogenesis Gene Sbds in Hematopoietic Stem and Progenitor Cells Causes Neutropenia in Mice by Attenuating Lineage Progression in Myelocytes
Researchers established the first mammalian model of neutropenia in Shwachman-Diamond syndrome through targeted downregulation of Sbds in hematopoietic stem and progenitor cells expressing the myeloid transcription factor CCAAT/enhancer binding protein α. [Haematologica] Abstract | Full Article

Autophagy Confers DNA Damage Repair Pathways to Protect the Hematopoietic System from Nuclear Radiation Injury
Investigators observed that ex vivo autophagy activation reversed the proliferation inhibition, apoptosis, and DNA damage in irradiated hematopoietic cells. [Sci Rep] Full Article

Frizzled-6 Regulates Hematopoietic Stem/Progenitor Cell Survival and Self-Renewal
Scientists showed that a noncanonical Wnt receptor, Frizzled-6, regulates hematopoietic stem/progenitor cell expansion and survival in a hematopoietic cell-intrinsic manner. [J Immunol] Abstract

The Drosophila Histone Demethylase dKDM5/LID Regulates Hematopoietic Development
The authors report the essential contribution of dKDM5/LID to hematopoiesis in Drosophila. Their results showed that dKDM5/LID is abundant in hemocytes and that its depletion induces over-proliferation and differentiation defects of larval hemocytes and disrupts organization of the actin cytoskeleton. [Dev Biol] Abstract


Stem Cell Transplantation in Severe Congenital Neutropenia: An Analysis from the European Society for Blood and Marrow Transplantation
Investigators report on the outcome of 136 severe congenital neutropenia patients who underwent hematopoietic stem cell transplantation between 1990 and 2012 in European and Middle East centers. [Blood] Abstract

Metabolic Syndrome in Adults Who Received Hematopoietic Stem Cell Transplantation for Acute Childhood Leukemia: An LEA Study
Researchers evaluated prospectively the incidence and risk factors of the metabolic syndrome and its components in 170 adult patients who received an hematopoietic stem cell transplantation for childhood. [Bone Marrow Transplant] Abstract

FLT3 Mutational Status Is an Independent Risk Factor for Adverse Outcomes after Allogeneic Transplantation in AML
The authors investigated FMS-like tyrosine kinase-3 (FLT3) mutational status on transplant outcomes. They conducted a retrospective cohort study of 262 consecutive AML patients who underwent first-time allogeneic hematopoietic cell transplantation, of whom 171 had undergone FLT3-internal tandem duplication mutational testing. [Bone Marrow Transplant] Abstract

Lost in Translation: Pluripotent Stem Cell-Derived Hematopoiesis
While the generation of fully defined hematopoietic stem cells from pluripotent stem cells (PSCs) remains challenging in vitro, the authors underline the instructive role of cell extrinsic factors such as cytokines for the generation of PSC-derived mature hematopoietic cells. [EMBO Mol Med] Full Article

BMSCs and Hematopoiesis
The authors review key molecular pathways, adhesion molecules and ligand/receptor interactions that mediate the crosstalk between bone marrow mesenchymal stem cells (BMSCs) and hematopoietic stem cells in health and disease. [Immunol Lett] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.
Amgen Announces Positive BLINCYTO® (Blinatumomab) Phase II Study Results in Patients with Relapsed/Refractory Philadelphia Chromosome-Positive B-Cell Precursor Acute Lymphoblastic Leukemia
Amgen announced the top-line results of a Phase II open-label, single-arm, multicenter trial to evaluate the efficacy and safety of BLINCYTO® in adults with relapsed or refractory Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia. [Amgen] Press Release

Medtown Ventures, LLC Announces Exclusive License Agreement with Georgia Tech Research Corporation
Medtown Ventures, LLC announced that it has entered into an exclusive license agreement with Georgia Tech Research Corporation for a new adhesive-signature based stem cell selection and isolation technology. [Medtown Ventures, LLC] Press Release

From our sponsor: Isolate human immune cells in as little as 8 minutes with EasySep™ Request a sample.
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Cell Symposia Meeting – Stem Cell Epigenetics
September 20-22, 2015
Sitges, Spain

Visit our events page to see a complete list of events in the hematopoiesis community.
NEW Research Associate – Cell Biology (Editas Medicine)

NEW Postdoctoral Research Fellow – Hematopoietic Stem and Progenitor Cell Gene Therapy (Fred Hutchinson Cancer Research Center)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

PhD Position – Drug Releasing, Nanostructured Biomaterials for Adult Stem Cells (Karlsruhe Institute of Technology)

Postdoctoral Position – Splicing in Hematopoiesis (Northwestern University)

Clinical Research Coordinator – Chronic Lymphocytic Leukemia (Fred Hutchinson Cancer Research Center)

Postdoctoral Position – Hematopoietic Stem Cell Transplantation (St. Jude Children’s Research Hospital)

Postdoctoral Position – Hematopoietic Stem Cell and Hematologic Malignancy (University of Kentucky College of Medicine)

Postdoctoral Fellow – Immune Reconstitution in Hematopoietic Stem Cell Transplantation (Stanford University)

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