Volume 6.19 | May 19

Hematopoiesis News 6.19 May 19, 2015
Hematopoiesis News
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Early Lineage Priming by Trisomy of Erg Leads to Myeloproliferation in a Down Syndrome Model
Researchers demonstrated that genetic changes specifically attributable to trisomy of Erg lead to lineage priming of primitive and early multipotential progenitor cells in Ts(1716)65Dn mice, excess megakaryocyte-erythroid progenitors, and malignant myeloproliferation. [PLoS Genet] Full Article
Live Webinar: New Tools for Ex Vivo Expansion of Human Hematopoietic Stem and Progenitor Cells
PUBLICATIONS (Ranked by impact factor of the journal)
Hhex Is Required at Multiple Stages of Adult Hematopoietic Stem and Progenitor Cell Differentiation
Conventional Hhex knockouts cause embryonic lethality precluding analysis of adult hematopoiesis. Thus, scientists induced highly efficient conditional knockout (cKO) using vav-Cre transgenic mice. Hhex cKO mice were viable and born at normal litter sizes. [Stem Cells] Abstract

ROS-Mediated Iron Overload Injures the Hematopoiesis of Bone Marrow by Damaging Hematopoietic Stem/Progenitor Cells in Mice
The authors investigated the effects of iron overload on the hematopoietic stem and progenitor cells (HSPCs) from a mouse model. Their results showed that iron overload markedly decreased the ratio and clonogenic function of murine HSPCs by the elevation of reactive oxygen species (ROS). [Sci Rep] Full Article

Stromal CYR61 Confers Resistance to Mitoxantrone via Spleen Tyrosine Kinase Activation in Human Acute Myeloid Leukemia
Investigators delineated the mechanisms underlying stroma-mediated chemoresistance in acute myeloid leukemia (AML). They used two human bone marrow stromal cell lines, HS-5 and HS-27A, which are equally effective in protecting AML cells from chemotherapy-induced apoptosis in AML-stromal co-cultures. [Br J Haematol] Abstract

Impact of the Immunomodulating Peptide Thymosin Alpha 1 on Multiple Myeloma and Immune Recovery after Hematopoietic Stem Cell Transplantation
The authors observed a slight reduction in the proliferation of murine and human multiple myeloma (MM) cell lines in the presence of thymosin α1 (Tα1) in vitro. However, using two immunocompetent murine MM models, they did not observe any impact of Tα1 administration on MM development in vivo. [Cancer Immunol Immunother] Abstract

Common Marmoset CD117-Positive Hematopoietic Cells Possess Multipotency
As stem cell factor (SCF) is an essential molecule for hematopoietic stem cell development in mice and humans, scientists focused on CD117, the SCF receptor, and examined whether CD117-expressing cells possess the hematopoietic stem/progenitor cell characteristics of newborn marmoset-derived hematopoietic cells that can develop into T cells and B cells. [Int Immunol] Abstract


Inducible Caspase-9 Suicide Gene Controls Adverse Effects from Alloreplete T Cells after Haploidentical Stem Cell Transplantation
To test the feasibility of a single T-cell manipulation to eliminate alloreactivity while sparing antiviral and antitumor T cells, investigators infused 12 haploidentical hematopoietic stem cell transplant patients with increasing numbers of alloreplete haploidentical T cells expressing the inducible caspase 9 suicide gene. [Blood] Abstract | Press Release

Reproducibility and Prognostic Significance of Morphologic Dysplasia in De Novo Acute Myeloid Leukemia
Researchers performed an in-depth analysis of morphologic dysplasia in 159 de novo acute myeloid leukemia cases lacking myelodysplasia-related cytogenetic abnormalities. [Mod Pathol] Abstract

Quality of the Hematopoietic Stem Cell Graft Affects the Clinical Outcome of Allogeneic Stem Cell Transplantation
The authors studied the impact of graft quality on clinical outcome and identify factors affecting graft quality. They investigated the influence of graft quality on the clinical outcome in 144 hematopoietic stem cell transplantation patients. [Transfusion] Abstract

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CXCR4/CXCL12 Signaling in Immature Hematopoiesis – Lessons from Pharmacological and Genetic Models
The authors seek to distil from the large body of information that has become available over the years some of the key findings about the role of CXCR4/CXCL12 in normal immature hematopoiesis. [Stem Cells] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.
Pivotal Data for Roche Medicines in Lung and Blood Cancers to Be Presented
Roche announced that data from ten of its approved cancer medicines and ten of its investigational medicines will be presented. These data demonstrate the strength of Roche’s oncology pipeline, particularly in cancer immunotherapy and personalized medicine. [Press release from Roche Ltd. discussing research to be presented at the 2015 American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago] Press Release

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Scientists Receive $15.7 Million to Develop Stem Cell Therapies to Treat Blood Disorders
A consortium of scientists and transplant clinicians from the Ansary Stem Cell Institute at Weill Cornell Medical College and the Center for Cell Engineering at Memorial Sloan Kettering Cancer Center has been awarded a $15.7 million, four-year research grant from the New York State Stem Cell Science Program to translate their innovative approach to expand and manipulate hematopoietic stem cells to cure acquired and inherited blood disorders. [Weill Cornell Medical College] Press Release

UB and Roswell Park Receive $1.85 Million Grant to Launch Stem Cell Research Program
University at Buffalo (UB) and Roswell Park Cancer Institute researchers have been awarded a $1.85 million grant to create an interdisciplinary stem cell research training program. The program, called Stem Cells in Regenerative Medicine, will bring together 18 faculty members in UB’s School of Engineering and Applied Sciences and the School of Medicine and Biomedical Sciences, and Roswell Park’s Graduate Division. [University of Buffalo] Press Release

EMA Grants Kiadis Pharma’s Lead Product ATIR™ ATMP Certificate for Quality and Non-Clinical Data
Kiadis Pharma B.V. announced that its lead product ATIR™ for blood cancers has been granted an Advanced Therapy Medicinal Product (ATMP) certificate for manufacturing quality and non-clinical data by the European Medicines Agency (EMA). [Kiadis Pharma B.V.] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW International Conference on Advances in Hematology and Oncology
August 28-29, 2015
Coeur d’Alene, United States

Visit our events page to see a complete list of events in the hematopoiesis community.
NEW Head of Cellular Therapies Laboratory (NHS Blood and Transplant)

NEW Postdoctoral Fellow – Immune Tolerance (Stanford University)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Position – Epigenetic Regulation of Hematopoiesis and Leukemia (Karolinska Institute)

Postdoctoral Scientist – Hematopoiesis (University of Oxford)

Postdoctoral Positions – Regulation of Normal and Malignant Hematopoiesis (Karolinska Institute)

Postdoctoral Researcher – Hematopoietic Stem Cell Physiology and Pathophysiology (International Research Center for Medical Sciences)

Postdoctoral Associate – Epigenetic Regulation of Normal and Leukemic Stem Cells (Sanford-Burnham Medical Research Institute)

Postdoctoral Fellow – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

Postdoctoral Research Fellow – Stem Cell/Hematopoiesis Research (BloodCenter of Wisconsin)

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