Notch Receptor-Ligand Engagement Maintains Hematopoietic Stem Cell Quiescence and Niche Retention
Using mice with conditional loss of O-fucosylglycans on Notch EGF-like repeats important for the binding of Notch ligands, researchers report that hematopoietic stem and progenitor cells with faulty ligand binding ability display enhanced cycling accompanied by increased egress from the marrow, a phenotype mainly attributed to their reduced adhesion to Notch ligand-expressing stromal cells and osteoblastic cells and their altered occupation in osteoblastic niches. [Stem Cells]
Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.
Juno’s CAR-T Contender Comes through in Another Phase I Leukemia Study
Juno Therapeutics, Inc. announced encouraging clinical responses in a Phase I study evaluating JCAR017 in pediatric patients with relapsed/refractory acute lymphoblastic leukemia. [Press release from Juno Therapeutics, Inc. discussing research presented at the American Association for Cancer Research (AACR) Annual Meeting 2015, Philadelphia] Press Release