Volume 6.14 | Apr 14

Hematopoiesis News 6.14 April 14, 2015
Hematopoiesis News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
TET1 Is a Tumor Suppressor of Hematopoietic Malignancy
Scientists found that deletion of Tet1 promoted the development of B cell lymphoma in mice. TET1 was required for maintenance of the normal abundance and distribution of 5-hydroxymethylcytosine, which prevented hypermethylation of DNA, and for regulation of the B cell lineage and of genes encoding molecules involved in chromosome maintenance and DNA repair. [Nat Immunol] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Ash1l Controls Quiescence and Self-Renewal Potential in Hematopoietic Stem Cells
Researchers report an essential role for the trithorax group gene absent, small, or homeotic 1-like (Ash1l) at this developmental transition. Emergence and expansion of Ash1l-deficient fetal/neonatal hematopoietic stem cells (HSCs) were preserved; however, in young adult animals, HSCs were profoundly depleted. [J Clin Invest] Full Article | Press Release

The Aryl Hydrocarbon Receptor Nuclear Translocator Is an Essential Regulator of Murine Hematopoietic Stem Cell Viability
Scientists conditionally deleted the hypoxia inducible factor α (HIF-α) dimerization partner, the aryl hydrocarbon receptor nuclear translocator (ARNT) in the hematopoietic system to ablate activity of both HIF-1α and HIF-2α and assessed the functional consequence of ARNT deficiency on fetal liver and adult hematopoiesis. [Blood] Abstract

SOCS2 Controls Proliferation and Stemness of Hematopoietic Cells Under Stress Conditions and Its Deregulation Marks Unfavorable Acute Leukemias
Investigators demonstrated that Socs2 deficiency unleashes hematopoietic stem cell proliferation in vitro sustaining STAT5 phosphorylation in response to IL-3, thrombopoietin and GM-CSF. [Cancer Res] Abstract

MYB Controls Erythroid versus Megakaryocyte Lineage Fate Decision through the miR-486-3p-Mediated Downregulation of MAF
To further unravel the molecular mechanisms through which v-myb avian myeloblastosis viral oncogene homolog (MYB) affects lineage fate decision, scientists performed the integrative analysis of miRNA and mRNA changes in MYB-silenced human primary CD34+ hematopoietic progenitor cells. [Cell Death Differ] Full Article

Targeting the Spliceosome in Chronic Lymphocytic Leukemia with the Macrolides FD-895 and Pladienolide B
The authors report studies using FD-895 and pladienolide-B in primary leukemia cells derived from chronic lymphocytic leukemia patients and leukemia-lymphoma cell lines. They found that FD-895 and pladienolide-B induce an early pattern of mRNA intron retention – spliceosome inhibition. [Haematologica]
Abstract | Full Article

Potential Role of Notch Signaling in CD34+ Chronic Myeloid Leukemia Cells: Cross-Talk between Notch and BCR-ABL
Researchers studied the relationship between BCR-ABL and Notch signaling and assessed the expression patterns of Notch and its downstream target Hes1 in CD34+ stem and progenitor cells from chronic-phase chronic myeloid leukemia patients and bone marrow from normal subjects. [PLoS One] Full Article

CLINICAL RESEARCH

Faster T-Cell Development following Gene Therapy Compared to Haplo-Identical Hematopoietic Stem Cell Transplantation in the Treatment of SCID-X1
Researchers retrospectively analyzed and compared clinical outcomes and immune reconstitution in 13 consecutive severe combined immunodeficiency caused by ILR2G mutation (SCID-X1) patients having undergone haploidentical hematopoietic stem cell transplantation and 14 SCID-X1 patients treated with gene therapy over the same period at a single center level. [Blood] Abstract | Full Article | Press Release

Mobilization of Hematopoietic Progenitor Stem Cells in Allogeneic Setting with Lenograstim by Subcutaneous Injection, in Daily or Twice-Daily Dosing: A Single-Center Prospective Study with Historical Control
Although the mobilization of hematopoietic progenitor stem cells from healthy donors (HDs) using granulocyte-colony-stimulating factor is widely used, the ideal method for the administration of the cytokine has not yet been determined. Seventy-five consecutive HDs received lenograstim as mobilization agent. [Transfusion] Abstract

Outcomes of Mismatched and Unrelated Donor Hematopoietic Stem Cell Transplantation in Fanconi Anemia Conditioned with Chemotherapy Only
Researchers present their experience with 17 Fanconi anemia patients who completed mismatched related or unrelated donor hematopoietic stem cell transplantation using a non-radiation fludarabine-based preparative regimen. [Ann Hematol] Abstract

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REVIEWS
The Dynamics of Adult Hematopoiesis in the Bone and Bone Marrow Environment
The authors explore the dynamic relationship between bone and bone marrow in the genesis and regulation of adult hematopoiesis and will provide an overview of the hematopoietic hierarchical system. [Br J Haematol] Abstract

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INDUSTRY NEWS
Mount Sinai Receives $8.8 Million Grant to Further Stem Cell Research
An $8.8 million grant from the New York State Stem Cell Science Program will accelerate efforts by the Icahn School of Medicine at Mount Sinai to develop new stem-cell-based treatments for chemotherapy-resistant blood cancer and other genetic blood disorders. [Icahn School of Medicine at Mount Sinai] Press Release

Cardio3 BioSciences Enrolls First Patient in Phase I Trial for NKG2D CAR T-Cell
Cardio3 BioSciences announced the enrollment of the first patient in a Phase I clinical trial evaluating the Company’s lead CAR T-Cell therapy, NKG2D CAR T-Cell, in blood cancer patients with acute myeloid leukemia or multiple myeloma. [Cardio3 BioSciences S.A.] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW The 2015 Tissue Engineering Congress
September 8-10, 2015
London, United Kingdom

Visit our events page to see a complete list of events in the hematopoiesis community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Fellow – Hematopoietic Stem Cell Biology (University of Leuven)

NEW Postdoctoral Fellow – Stem Cell Trans Regulation (BloodCenter of Wisconsin)

NEW Postdoctoral Fellow – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Hematopoietic Stem Cell Research (Lund University)

Postdoctoral Research Fellow – Stem Cell/Hematopoiesis Research (BloodCenter of Wisconsin)

Postdoctoral Fellow – Bioinformatics and Stem Cell Biology (The University of Texas Medical School at Houston)

Research Associate – Hematopoietic and Leukemic Stem Cells (Shanghai Jiao Tong University)

Postdoctoral Position – Drug Development for Anemia (Lund University)


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