Volume 6.12 | Mar 31

Hematopoiesis News 6.12 March 31, 2015
Hematopoiesis News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
IL8-CXCR2 Pathway Inhibition as a Therapeutic Strategy against MDS and AML Stem Cells
Investigators conducted parallel transcriptional analysis of highly fractionated stem and progenitor populations in MDS, AML and control samples and found interleukin 8 (IL8) to be consistently overexpressed in patient samples. [Blood] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Loss of Dnmt3a and Endogenous KrasG12D/+ Cooperate to Regulate Hematopoietic Stem and Progenitor Cell Functions in Leukemogenesis
Researchers found that Dnmt3a-/- induces multiple hematopoietic phenotypes after a prolonged latency, including T cell expansion in peripheral blood, stress erythropoiesis in spleen, and myeloid malignancies in liver. [Leukemia] Abstract

Induction of Hematopoietic and Endothelial Cell Program Orchestrated by ETS Transcription Factor ER71/ETV2
Scientists mapped ETV2 global binding sites and carry out in vitro differentiation of embryonic stem cells, and germ line and conditional knockout mouse studies to uncover mechanisms involved in the hemangiogenic fate commitment from mesoderm. [EMBO Rep] Abstract | Graphical Abstract

EphB2 and EphB3 Play an Important Role in the Lymphoid Seeding of Murine Adult Thymus
Adult thymuses lacking either ephrin type B receptor 2 (EphB2) or EphB3, or expressing a truncated form of EphB2, the forward signal-deficient EphB2LacZ, have low numbers of early thymic progenitors and are colonized in vivo by reduced numbers of injected bone marrow lineage-negative cells. Hematopoietic progenitors from these EphB mutants showed decreased capacities to colonize wild type (WT) thymuses compared with WT precursors, with EphB2-/- cells exhibiting the greatest reduction. [J Leukoc Biol] Abstract

Detecting Primitive Hematopoietic Stem Cells in Total Nucleated and Mononuclear Cell Fractions from Umbilical Cord Blood Segments and Units
63 umbilical cord blood (UCB) segments and 10 UCB units plus segments were analyzed for the response of both primitive lympho-hematopoietic and primitive hematopoietic stem cells in both the total nucleated cell and mononuclear cell fractions. [J Transl Med] Full Article

Wnt3a Protein Reduces Growth Factor-Driven Expansion of Human Hematopoietic Stem and Progenitor Cells in Serum-Free Cultures
Scientists demonstrated that exogenous Wnt3a protein suppresses rather than promotes the expansion of umbilical cord blood-derived CD34+ cells in serum free expansion cultures. [PLoS One] Full Article

Mitochondria Defects Are Involved in Lead-Acetate-Induced Adult Hematopoietic Stem Cell Decline
Investigators performed oral intragastric administration of various dose lead acetate to adult Sprague Dawley rats to define the role of lead exposure in hematopoietic stem cells function, and to clarify its underlying mechanism. [Toxicol Lett] Abstract

CLINICAL RESEARCH

Allogeneic Stem Cell Transplantation May Improve the Outcome of Adult inv(16) Acute Myeloid Leukemia Patients in First Complete Remission with Poor Molecular Responses to Chemotherapy
86 adult inv(16) acute myeloid leukemia patients in the first complete remission were serially monitored for CBFB-MYH11 transcript levels during the early courses of chemotherapy. 57 and 29 of them received chemotherapy/autologous SCT and allo-SCT after the second consolidation, respectively. [Leuk Lymphoma] Abstract

Thiotepa-Based versus Total Body Irradiation-Based Myeloablative Conditioning Prior to Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia in First Complete Remission: A Retrospective Analysis from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation
Investigators evaluated the outcome of adults with acute myeloid leukemia in first complete remission who received myeloablative conditioning either with a thiotepa-based or a cyclophosphamide/total body irradiation-based regimen for allogeneic hematopoietic stem cell transplantation from an HLA-matched sibling or an unrelated donor. [Eur J Haematol] Abstract

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REVIEWS
Advances and Challenges in Immunotherapy for Solid Organ and Hematopoietic Stem Cell Transplantation
The authors outline the current immunological limitations for hematopoietic stem cell and solid organ transplantation and discuss new immune-modulating therapies in preclinical development and in clinical trials that may allow these obstacles to be overcome. [Sci Transl Med] Abstract

Cellular Innate Immunity and Restriction of Viral Infection – Implications for Lentiviral Gene Therapy in Human Hematopoietic Cells
The authors summarize the current knowledge regarding innate immune recognition of lentiviruses in primary human hematopoietic cells as well as discuss its relevance for lentiviral vector-based ex-vivo gene therapy approaches. [Hum Gene Ther] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

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INDUSTRY NEWS
Accellta Grants Exclusive Rights for Micro-Carrier Free Stem Cells Suspension Culture to STEMCELL Technologies
The stem cell company Accellta announced that it has granted exclusive worldwide rights to STEMCELL Technologies Inc. for manufacturing and distribution of medium for culturing pluripotent stem cells in suspension under feeder-free, non-adherent conditions. [Accellta Ltd.] Press Release

BioLineRx Reports Successful Top-Line Safety and Efficacy Results for Novel Stem Cell Mobilization Treatment
BioLineRx Ltd. announced successful top-line results from the Phase I safety and efficacy study of its lead clinical candidate, BL-8040, as a novel approach for mobilization and collection of bone-marrow stem cells from the peripheral blood circulation. [BioLineRx Ltd.] Press Release

Researchers Aim to Broaden Understanding of How Toxins Affect the Body
University of Wisconsin-Madison researchers received $6 million from the U.S. Environmental Protection Agency to develop models and screening tools that will rapidly advance knowledge of the health effects of an ever-growing assortment of environmental toxins. Awarded through the EPA Science to Achieve Results program, the grant will create the Human Models for Analysis of Pathways Center at UW-Madison. [University of Wisconsin-Madison] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Stem Cells: From Basic Research to Bioprocessing
June 9-11, 2015
London, United Kingdom

Visit our events page to see a complete list of events in the hematopoiesis community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Research Fellow – Stem Cell/Hematopoiesis Research (BloodCenter of Wisconsin)

NEW Postdoctoral Fellow – Bioinformatics and Stem Cell Biology (The University of Texas Medical School at Houston)

NEW Research Associate – Hematopoietic and Leukemic Stem Cells (Shanghai Jiao Tong University)

Research Technologist – Hematopoietic Product Development (STEMCELL Technologies Inc.)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Research Fellow – Hematopoietic Stem Cell Biology (University of Leuven)

Manufacturing Manager – Cell Therapy (Opexa Therapeutics)

Research Scientist – Cell Signaling in Normal and Leukemic Hematopoietic Stem and Progenitor Cells (Indiana University)

Postdoctoral Position – Drug Development for Anemia (Lund University)

Postdoctoral Position – Pediatric Hematology and Oncology (University Medical Center of Freiburg)


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