Volume 6.10 | Mar 17

Hematopoiesis News 6.10 March 17, 2015
Hematopoiesis News
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Cellular Reprogramming Allows Generation of Autologous Hematopoietic Progenitors from AML Patients that Are Devoid of Patient-Specific Genomic Aberrations
Researchers report the generation of human acute myeloid leukemia (AML) patient-specific hematopoietic progenitors that are capable of normal in vitro differentiation to myeloid lineages and are devoid of leukemia-associated aberration found in matched patient bone marrow. [Stem Cells] Abstract
Get your experiments started right away with fresh human peripheral whole blood
PUBLICATIONS (Ranked by impact factor of the journal)
Sumoylation of CCAAT/Enhancer-Binding Protein α Is Implicated in Hematopoietic Stem/Progenitor Cell Development through Regulating runx1 in Zebrafish
Scientists showed that definitive hematopoietic stem/progenitor cells (HSPCs) are depleted in small ubiquitin-related modifier (SUMO)-deficient zebrafish embryos. Impairment of sumoylation attenuates HSPC generation and proliferation. [Sci Rep] Full Article

Shedding of Clinical-Grade Lentiviral Vectors Is Not Detected in a Gene Therapy Setting
Researchers investigated factors influencing the extent of lentiviral vector shedding upon ex vivo transduction of human hematopoietic stem and progenitor cells. [Gene Ther] Abstract

Hematopoietic Stem Cell Gene Therapy Corrects the Neuropathic Phenotype in Murine Model of Mucopolysaccharidosis Type II
Investigators showed that lentiviral isogeneic hematopoietic stem cell gene therapy corrects the neuronal manifestation through the amelioration of lysosomal storages and autophagic dysfunctions in brains from mucopolysaccharidosis type II mice. [Hum Gene Ther] Abstract

Expression of Coxsackievirus and Adenovirus Receptor Separates Hematopoietic and Cardiac Progenitor Cells in Fetal Liver Kinase 1-Expressing Mesoderm
Scientists found that mouse and human pluripotent stem cell- and mouse embryo-derived fetal liver kinase 1 (Flk1)+ cells could be subdivided into Flk1+ coxsackievirus and adenovirus receptor (CAR)+ cells and Flk1+CAR cells. The progenitor cells with cardiac potential were almost entirely restricted to Flk1+CAR+ cells, and Flk1+CAR cells efficiently differentiated into hematopoietic cells. [Stem Cells Transl Med] Abstract

Pluripotent Cell Models of Fanconi Anemia Identify the Early Pathological Defect in Human Hemoangiogenic Progenitors
Researchers established induced pluripotent stem cells (iPSCs) from fibroblasts of six patients with Fanconi anemia (FA) and FANCA mutations. Quantitative evaluation of the differentiation ability demonstrated that the differentiation propensity toward the hematopoietic and endothelial lineages is already defective in early hemoangiogenic progenitors. [Stem Cells Transl Med] Abstract

Dual Roles of Autologous CD8+ T Cells in Hematopoietic Progenitor Cell Mobilization and Engraftment
Scientists assessed the effect of purified autologous CD8+ T cells from low and high mobilizers on hematopoietic progenitor cell migration from high to low stromal cell-derived factor concentration gradients. [Transfusion] Abstract


Phase I Study of a Bispecific Ligand-Directed Toxin Targeting CD22 and CD19 (DT2219) for Refractory B-Cell Malignancies
Investigators conducted a Phase I dose-escalation study to assess the safety, maximum tolerated dose, and preliminary efficacy of DT2219 in patients with relapsed/refractory B-cell lymphoma or leukemia. [Clin Cancer Res] Abstract | Press Release

Strategies to Inhibit Alloantibody Production in Alloprimed Murine Recipients of Hematopoietic Stem Cell Grafts
Researchers showed that a single intravenous injection of donor splenocytes, to mimic a blood transfusion, results in high, sustained levels of serum alloantibody sufficient to eliminate donor bone marrow within three hours, resulting in uniform mortality in lethally irradiated allogeneic recipients. [Am J Transplant] Abstract

The Impact of Graft-versus Host Disease Prophylaxis in Reduced-Intensity Conditioning Allogeneic Stem Cell Transplant in Acute Myeloid Leukemia: A Study from the Acute Leukemia Working Party of EBMT
The impact of the intensity of graft-versus-host-disease immunoprophylaxis on transplantation outcomes in patients undergoing transplantation following reduced-intensity conditioning is unclear. Investigators address this question in 228 adult patients above 50 years of age with acute myeloid leukemia in first complete remission given peripheral blood stem cells from HLA-identical siblings after fludarabine and two days of intravenous busulfan reduced-intensity conditioning. [Haematologica] Abstract | Full Article

March Magnet Maddness: Free EasySep™ Magnet with Purchase of Cell Isolation Reagents
Hematopoietic Stem Cells: Concepts, Definitions and the New Reality
Developments have led to the formulation of increasingly complex hierarchical models of hematopoiesis and a growing list of intrinsic and extrinsic elements that regulate hematopoietic stem cell cycling status, viability, self-renewal and lineage outputs. [Blood] Abstract

Deregulation of Innate Immune and Inflammatory Signaling in Myelodysplastic Syndromes
The deregulation of innate immune and inflammatory signaling should be considered one of the driving forces in the pathogenesis of MDS. The authors review and update the advances in this field, summarizing the results from the most recent studies and discussing their clinical implications. [Leukemia] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.
NeoStem Announces PreSERVE AMI Clinical Trial One-Year Follow-Up Results
NeoStem, Inc. announced presentation of updated efficacy and safety results from the one-year follow-up for its Phase II PreSERVE study and additional analyses of certain functional tests. [Press release from NeoStem, Inc. discussing research presented at the American College of Cardiology’s 64th Annual Scientific Session and Expo, San Diego] Press Release

From our sponsor: Free mouse hematopoietic progenitors wallchart. Request your copy.
VAXIL Receives EU Orphan Drug Designation for ImMucin for the Treatment of Multiple Myeloma
Vaxil Bio reports that its lead drug candidate, ImMucin has received orphan drug designation from the European Medicines Agency of the European Commission for the treatment of Multiple Myeloma. [Vaxil Bio Ltd.] Press Release

The Alliance for Regenerative Medicine Enters into Memorandum of Understanding with Japan’s Forum for Innovative Regenerative Medicine
The Alliance for Regenerative Medicine announced it has entered into a memorandum of understanding with Japan’s Forum for Innovative Regenerative Medicine, effective immediately. [The Alliance for Regenerative Medicine] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 2015 World Stem Cell Summit (WSCS15)
December 10-12, 2015
Atlanta, United States

Visit our events page to see a complete list of events in the hematopoiesis community.
NEW Manufacturing Manager – Cell Therapy (Opexa Therapeutics)

Research Technologist – Hematopoietic Product Development (STEMCELL Technologies Inc.)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Scientist – Cell Signaling in Normal and Leukemic Hematopoietic Stem and Progenitor Cells (Indiana University)

Postdoctoral Fellow – Stem Cell/Translational Medicine (Rutgers New Jersey Medical School)

Postdoctoral Position – Drug Development for Anemia (Lund University)

Postdoctoral Position – Pediatric Hematology and Oncology (University Medical Center of Freiburg)

Senior Process Development Engineer (Sangamo BioSciences, Inc.)

Director – Vector Production (Sangamo BioSciences, Inc.)

Postdoctoral Position – Genetic Engineering and Transplantation of Hematopoietic Stem Cells (University of California – San Francisco)

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