Volume 6.07 | Feb 24

Hematopoiesis News 6.07 February 24, 2015
Hematopoiesis News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
A Good Night’s Sleep Keeps Your Stem Cells Young
Scientists have uncovered that environmental stress is a major factor in driving DNA damage in adult hematopoietic stem cells. Repeated exposure to such stress causes accelerated tissue aging and probably cancer. [Press release from German Cancer Research Center discussing online publication in Nature]
Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
CDK6 Levels Regulate Quiescence Exit in Human Hematopoietic Stem Cells
Researchers report that quiescence exit kinetics are differentially regulated within human hematopoietic stem cell subsets through the expression level of CDK6. [Cell Stem Cell] Full Article | Graphical Abstract

Restricted Dendritic Cell and Monocyte Progenitors in Human Cord Blood and Bone Marrow
Scientists report a culture system that supports development of CD34+ hematopoietic stem cell progenitors into the three major human dendritic cell subsets, monocytes, granulocytes, and NK and B cells. [J Exp Med] Abstract

Primitive Macrophages Control HSPC Mobilization and Definitive Hematopoiesis
The authors identified an unexpected primitive macrophage population accumulated in the dorsal mesenteric mesoderm surrounding the dorsal aorta of the human embryo and studied its function in the transparent zebrafish embryo. They revealed dynamic interactions occurring between hematopoietic stem/progenitor cells (HSPCs) and primitive macrophages in the aorta-gonad-mesonephros. [Nat Commun] Abstract

Estrogen-Inducible sFRP5 Inhibits Early B-Lymphopoiesis In Vivo, but Not during Pregnancy
Scientists showed that estrogen-induced soluble Frizzled-related proteins (sFRPs), and particularly sFRP5, suppress B-lymphopoiesis in vivo in transgenic mice. sFRP5 deficiency reduced the number of hematopoietic stem cells and primitive lymphoid progenitors in the bone marrow, particularly when estrogen was administered. [Eur J Immunol] Abstract

Overexpression of Hiwi Inhibits the Growth and Migration of Chronic Myeloid Leukemia Cells
Expression deletion of Hiwi, a human Piwi homolog, has been reported to be implicated in leukemogenesis. Researchers explored Hiwi’s role in chronic myeloid leukemia (CML) pathogenesis by determining how and whether its forced overexpression could affect CML cell growth and migration. [Cell Biochem Biophys] Abstract

CLINICAL RESEARCH

Phase I/II Study of the Combination of Panobinostat and Carfilzomib in Patients with Relapsed/Refractory Multiple Myeloma
Investigators assessed the safety and efficacy of the combination of panobinostat and carfilzomib in patients with relapsed/refractory multiple myeloma. [Haematologica] Abstract | Full Article

Haploidentical Hematopoietic Stem Cell Transplantation without In Vitro T-Cell Depletion for the Treatment of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia
Researchers investigated the long-term survival of Philadelphia chromosome-positive acute lymphoblastic leukemia patients who underwent haploidentical donor hematopoietic stem cell transplantation (HSCT) and analyzed the factors influencing relapse and survival after allogeneic HSCT. [Biol Blood Marrow Transplant] Abstract

Effect of ATG-F on B Cell Reconstitution after Hematopoietic Stem Cell Transplantation
Little is known about the effect of antithymocyte globulin Fresenius (ATG-F) on the reconstitution of B cell subsets. 67 patients were longitudinally studied at day 15, day 30 and then monthly after hematopoietic stem cell transplantation. [Eur J Haematol] Abstract

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REVIEWS
DNMT3A in Hematological Malignancies
The authors review the clinical findings related to DNA methyltransferase 3A (DNMT3A), tie these data to insights from basic science studies conducted over the past 20 years and present a roadmap for future research that should advance the agenda for new therapeutic strategies. [Nat Rev Cancer] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.
 
INDUSTRY NEWS
Georgia State Scientists get $2.7 Million CDC Grant to Improve Blood Transfusion Outcomes
The Georgia Health Policy Center (GHPC) at Georgia State University has received a five-year, $2,669,903 award from the U.S. Centers for Disease Control and Prevention (CDC) that will allow the GHPC and partnering organizations to look at transfusion-related complications in patients with hemoglobin disorders (sickle cell disease and thalassemia) and improve their outcomes. [Georgia State University] Press Release

MD Anderson Receives $22.3 Million in CPRIT Research Funding
The University of Texas MD Anderson Cancer Center has received more than $22 million in research grants from the Cancer Prevention and Research Institute of Texas (CPRIT). The CPRIT awards will go toward studies in the areas of breast, skin, prostate, pancreas, colon and lung cancers in adults; leukemia and brain cancer in children, and for studies aimed at preventing colon cancer and lung cancer. [The University of Texas MD Anderson Cancer Center] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW International Society for Cellular Therapy (ISCT) 21st Annual Meeting
May 27-30, 2015
Las Vegas, United States

Visit our events page to see a complete list of events in the hematopoiesis community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Position – Drug Development for Anemia (Lund University)

Research Technologist – Hematopoietic Product Development (STEMCELL Technologies Inc.)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Scientist – Hematopoietic Stem Cell Transplantation (Indiana University)

Postdoctoral Position – Pediatric Hematology and Oncology (University Medical Center of Freiburg)

Senior Process Development Engineer (Sangamo BioSciences, Inc.)

Director – Vector Production (Sangamo BioSciences, Inc.)

Postdoctoral Position – Hematopoietic Stem Cell Physiology and Pathophysiology (Kumamoto University)

Postdoctoral Position – Genetic Engineering and Transplantation of Hematopoietic Stem Cells (University of California – San Francisco)

Research Associate – Hematopoietic Stem Cells and Leukemia (City of Hope)

Postdoctoral Research Fellow – Post-Transcriptional Gene Regulation Governing Cancer Cell Behavior (Fred Hutchinson Cancer Research Center)


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