Volume 6.01 | Jan 13

Hematopoiesis News 6.01 January 13, 2015
Hematopoiesis News
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Scl Binds to Primed Enhancers in Mesoderm to Regulate Hematopoietic and Cardiac Fate Divergence
Researchers discovered that Scl binds to hematopoietic and cardiac enhancers that become epigenetically primed in multipotent cardiovascular mesoderm, to regulate the divergence of hematopoietic and cardiac lineages. [EMBO J] Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
ZEB2 Drives Immature T-Cell Lymphoblastic Leukemia Development via Enhanced Tumor-Initiating Potential and IL-7 Receptor Signaling
Researchers report translocations targeting the zinc finger E-box-binding transcription factor ZEB2 as a recurrent genetic lesion in immature/early T-cell precursor leukemia. [Nat Commun] Full Article

Vasculopathy-Associated Hyperangiotensinemia Mobilizes Hematopoietic Stem Cells/Progenitors through Endothelial At2R and Cytoskeletal Dysregulation
Investigators define for the first time the role of angiotensin II hematopoietic stem cells and progenitor traffic regulation and redefine the hematopoietic consequences of anti-angiotensin therapy in sickle cell disease. [Nat Commun] Abstract

Programmable 3D Silk Bone Marrow Niche for Platelet Generation Ex Vivo and Modeling of Megakaryopoiesis Pathologies
Scientists present a programmable bioengineered three-dimensional silk based bone marrow niche tissue system that successfully mimics the physiology of human bone marrow environment allowing them to manufacture functional human platelets ex vivo. [Blood] Abstract

HIF-1α Is Required for Hematopoietic Stem Cell Mobilization and 4-Prolyl Hydroxylase Inhibitors Enhance Mobilization by Stabilizing HIF-1α
In order to discover alternative targetable pathways to enhance hematopoietic stem cell (HSC) mobilization, investigators studied the role of hypoxia-inducible factor-1α (HIF1α) and the effect of HIF-1α pharmacological stabilization on HSC mobilization in mice. [Leukemia] Full Article

Oncostatin M Maintains the Hematopoietic Microenvironment in the Bone Marrow by Modulating Adipogenesis and Osteogenesis
Oncostatin M allowed mesenchymal stromal cell-derived cells to support the ex vivo expansion of hematopoietic stem/progenitor cells effectively as feeder cells. [PLoS One] Full Article

Invariant Natural Killer T Cells Generated from Human Adult Hematopoietic Stem-Progenitor Cells Are Poly-Functional
To overcome the problem of limited invariant natural killer T (iNKT) cell numbers, researchers investigated whether iNKT cells can be generated in vitro from bone marrow-derived adult hematopoietic stem-progenitor cells. [Cytokine] Abstract


Outcomes of Patients with Chronic Lymphocytic Leukemia (CLL) after Discontinuing Ibrutinib
Ibrutinib is a Bruton’s tyrosine kinase inhibitor approved for the treatment of patients with relapsed refractory CLL. Scientists describe the characteristics, causes of discontinuation and outcomes in patients who discontinued treatment with ibrutinib. [Blood] Abstract

Molecular Profiling of Myeloid Progenitor Cells in Multi-Mutated Advanced Systemic Mastocytosis Identifies KIT D816V as a Distinct and Late Event
To explore the molecular profile and its prognostic implication in systemic mastocytosis (SM), investigators analyzed the mutation status of granulocyte-macrophage colony-forming progenitor cells in patients with KIT D816V+ indolent systemic mastocytosis, smoldering SM, aggressive SM (ASM), SM with associated clonal hematologic non-mast cell lineage disorder (SM-AHNMD) and ASM-AHNMD. [Leukemia] Abstract

Single Thrombopoietin Dose Alleviates Hematopoietic Stem Cells Intrinsic Short- and Long-Term Ionizing Radiation Damage. In Vivo Identification of Anatomical Cell Expansion Sites
Investigators examined the role of thrombopoietin (TPO) on the regenerative capacities of hematopoietic stem cells (HSC) after irradiation and report the first demonstration of efficacy of a single injection of TPO shortly after in vivo exposure to ionizing radiation for reducing HSC injury and improving their functional outcome. [Radiat Res] Abstract

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Pegfilgrastim vs Filgrastim in PBSC Mobilization for Autologous Hematopoietic SCT: A Systematic Review and Meta-Analysis
Trial outcomes comparing cytokine agents for PBSC mobilization in autologous hematopoietic transplant patients have been controversial. The authors performed a systematic review and meta-analysis of evidence available on pegfilgrastim vs filgrastim in chemo-cytokine mobilization. [Bone Marrow Transplant] Abstract

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Intellia Therapeutics, Novartis Form Partnership to Develop New Cell Therapies Using CRISPR/Cas9 Technology
Intellia Therapeutics announced a five-year research and development collaboration with Novartis to accelerate the ex vivo development of new CRISPR/Cas9-based therapies using chimeric antigen receptor T cells and hematopoetic stem cells. [Intellia Therapeutics] Press Release

Actinium Initiates cGMP Manufacturing of Iomab-B for Phase III Clinical Trial
Actinium Pharmaceuticals, Inc. announced it has initiated manufacturing of the Phase III clinical lot of BC8, a novel murine monoclonal antibody, which is conjugated with iodine-131 radioisotope to form Iomab-B. [Actinium Pharmaceuticals, Inc.] Press Release

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NEW Postdoctoral Scholar – Regulation of Hematopoietic Stem Cell Functions (University of Kentucky College of Medicine)

Postdoctoral Fellow – Hematopoiesis and Stem Cell Biology (Lund University)

Postdoctoral Research Scientist – Human T Cell Leukemia (Washington University School of Medicine)

Postdoctoral Research Fellow – Post-Transcriptional Gene Regulation Governing Cancer Cell Behavior (Fred Hutchinson Cancer Research Center)

PhD Student – Experimental Leukemia Research (University Children’s Hospital Basel)

Research Associate – Hematopoietic and Leukemic Stem Cells (Shanghai Jiao-Tong University)

Mesenchymal Stem Cell (MSC) Laboratory Technician (California Cryobank)

Clinical Laboratory Scientist – Umbilical Cord Blood Processing (California Cryobank)

Postdoctoral Researcher – Chromatin and Epigenetic Regulation (Van Andel Research Institute)

Postdoctoral Fellow – Stem Cell Biology Gene Expression and Regulation (The University of Texas Medical School At Houston)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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