Volume 5.45 | Dec 2

Hematopoiesis News 5.45 December 2, 2014
Hematopoiesis News
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Two Studies Identify a Detectable, Pre-Cancerous State in the Blood
Researchers have uncovered an easily detectable, “pre-malignant” state in the blood that significantly increases the likelihood that an individual will go on to develop blood cancers such as leukemia, lymphoma, or myelodysplastic syndrome. [Press release from The Broad Institute discussing online prepublication in The New England Journal of Medicine] Press Release | Editorial | Abstract 1 | Abstract 2
Take the "if" out of "diff": Reduce variability when differentiating to hematopoietic cells
PUBLICATIONS (Ranked by impact factor of the journal)
FGF Signaling Restricts Hematopoietic Stem Cell Specification via Modulation of the BMP Pathway
The authors demonstrate a novel requirement for FGF signaling in the specification of aortic hemogenic endothelium. Their results demonstrate that FGF signaling normally acts to repress BMP activity in the subaortic mesenchyme through transcriptional inhibition of bmp4, as well as through activation of two BMP antagonists, noggin2 and gremlin1a. [Nat Commun] Abstract

FGF Signaling Specifies Hematopoietic Stem Cells through Its Regulation of Somitic Notch Signaling
Researchers demonstrate a novel requirement for fibroblast growth factor (FGF) signaling in hematopoietic stem cell emergence. This requirement is non-cell-autonomous, and acts within the somite to bridge the Wnt and Notch signaling pathways. [Nat Commun] Abstract

Disruption of SF3B1 Results in Deregulated Expression and Splicing of Key Genes and Pathways in Myelodysplastic Syndrome Hematopoietic Stem and Progenitor Cells
Scientists investigated the functional effects of SF3B1 disruption in myeloid cell lines: SF3B1 knockdown resulted in growth inhibition, cell cycle arrest and impaired erythroid differentiation, and deregulation of many genes and pathways, including cell cycle regulation and RNA processing. [Leukemia] Abstract | Full Article

Constrained Transcription Factor Spacing Is Prevalent and Important for Transcriptional Control of Mouse Blood Cells
Utilizing a compendium of 289 mouse hematopoietic transcription factor ChIP-seq datasets, investigators demonstrate that hematopoietic-related motif-pairs commonly occur with highly conserved constrained spacing and orientation between motifs. [Nucleic Acids Res] Full Article

Abundance of the Fanconi Anemia Core Complex Is Regulated by the RuvBL1 and RuvBL2 AAA+ ATPases
Scientists show that the RuvBL1 and RuvBL2 adenosine triphosphatases associated with diverse cellular activities (AAA+ ATPases) co-purify with Fanconi anemia (FA) core complex isolated under stringent but native conditions from a vertebrate cell line. Depletion of the RuvBL1-RuvBL2 complex in human cells causes hallmark features of FA including DNA crosslinker sensitivity, chromosomal instability and defective FA pathway activation. [Nucleic Acids Res] Full Article

Wnt Signaling Is Involved in 6-Benzylthioinosine-Induced AML Cell Differentiation
Researchers investigated whether Wnt signaling pathways played roles in 6-benzylthioinosine-induced differentiation of acute myeloid leukemia (AML) cells. [BMC Cancer] Abstract | Full Article


Comparative Therapeutic Value of Post Remission Approaches in Patients with Acute Myeloid Leukemia Aged 40-60 Years
Researchers report results of a time-dependent multivariable analysis of alloHSCT versus chemotherapy or autologous HSCT in 760 patients aged 40 and 60 years with acute myeloid leukemia in first complete remission. [Leukemia] Abstract

Pharmacogenetic Studies in Children with Acute Lymphoblastic Leukemia in Argentina
Investigators evaluated the influence of the most common genetic variants in methylenetetrahydrofolate reductase, thiopurine methyltransferase and glutathione-S-transferases on the outcome of acute lymphoblastic leukemia treatment in Argentinean children. [Leuk Lymphoma] Abstract

Technical Bulletin: Assays For Cord Blood
Reversible Inhibitors of LSD1 as Therapeutic Agents in Acute Myeloid Leukemia: Clinical Significance and Progress to Date
The authors cover clinical aspects of acute myeloid leukemia (AML), the role of epigenetics in the disease, and discuss the research that led to the first irreversible inhibitors of lysine-specific demethylase 1 (LSD1) entering clinical trials for the treatment of AML in 2014. [Med Res Rev] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

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Unum Therapeutics Announces Start of First Phase I Clinical Trial of Cellular Immunotherapy Targeting CD20+ Chronic Lymphocytic Leukemia and Non-Hodgkin Lymphoma
Unum Therapeutics announced that recruitment has begun in the first clinical trial of the ATTCK20 therapy. The Phase I study will examine the feasibility, safety and potential efficacy of infusing the ATTCK20 combination therapy in patients with B-cell malignancies and persistent disease following standard therapy. [Unum Therapeutics] Press Release

CPRIT Awards UTSW Faculty $22.5 Million for Recruitment and Research in Liver Cancer, Leukemia, and Immunotherapy
UT Southwestern Medical Center faculty was awarded seven grants totaling more than $22 million from the Cancer Prevention and Research Institute of Texas (CPRIT) for investigations into leukemia, liver cancer, and immunotherapy, as well as to recruit new faculty. [UT Southwestern Medical Center] Press Release

Actinium Receives Orphan-Drug Designation from FDA for Actimab-A in the Treatment of Newly Diagnosed Acute Myeloid Leukemia in Elderly Patients
Actinium Pharmaceuticals, Inc. announced that the US Food and Drug Administration (FDA) has granted orphan-drug designation for Actimab-A, an alpha radiolabeled antibody being developed for newly diagnosed AML in patients over the age of 60. [Actinium Pharmaceuticals, Inc.] Press Release

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NEW Keystone Symposia – Epigenetics and Cancer
January 25-30, 2015
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Visit our events page to see a complete list of events in the hematopoiesis community.
NEW Postdoctoral Research Positions – Pathways Governing Lineage Commitment from Hematopoietic Stem Cells (Karolinska Institutet)

Mesenchymal Stem Cell (MSC) Laboratory Technician (California Cryobank)

Clinical Laboratory Scientist – Umbilical Cord Blood Processing (California Cryobank)

Head of Cellular and Molecular Therapies Laboratory (NHS Blood & Transplant)

Postdoctoral Researcher – Chromatin and Epigenetic Regulation (Van Andel Research Institute)

Postdoctoral Position – Post-Transcriptional Control of Gene Expression in Hematopoietic Stem Cells (Lund University)

Postdoctoral Fellow – Stem Cell Biology Gene Expression and Regulation (The University of Texas Medical School At Houston)

PhD Studentship – Discovery of Key Regulators of Normal and Leukemic Stem Cell Functions (University of Edinburgh)

Stem Cell Biology Program Director (Blood Research Institute of BloodCenter of Wisconsin)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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