Cdk4 and Cdk6 Cooperate in Counteracting the INK4 Family of Inhibitors during Murine Leukemogenesis
Cdk6 R31C impairs the potential of hematopoietic progenitors to repopulate upon adoptive transfer or after 5-fluorouracil-induced damage. The defects are overcome by eliminating sensitivity of cells to INK4 inhibitors by introducing the INK4-insensitive Cdk4 R24C allele, and INK4-resistant mice are more susceptible to hematopoietic and endocrine tumors. [Blood] Abstract|Press Release
Viability and Stress Protection of Chronic Lymphoid Leukemia Cells Involves Overactivation of Mitochondrial PhosphoSTAT3Ser727
Scientists report on a novel STAT3-mediated pathway that characterizes chronic lymphoid leukemia (CLL) B cells-extended viability and oxidative stress control. They observed that leukemic but not normal B cells from CLL patients exhibit constitutive activation of an atypical form of the STAT3 signaling factor, phosphorylated on serine 727 (Ser727) in the absence of detectable canonical tyrosine 705-dependent activation in vivo. [Cell Death Dis] Full Article
Obesity-Driven Disruption of Hematopoiesis and the Bone Marrow Niche
This review discusses the differentiation and function of hematopoietic cell populations, the principal physicochemical components of the bone marrow niche, and how this environment influences hematopoietic stem cells and hematopoiesis in general. [Nat Rev Endocrinol] Abstract
Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.
Recruit Top Talent: Reach more than 50,000 potential candidates by posting
your organization’s career opportunities on the Connexon Creative Job Board at no cost.
Have we missed an important article or publication in Hematopoiesis News? Click here to submit!