Volume 5.35 | Sep 16

Hematopoiesis News 5.35 September 16, 2014
Hematopoiesis News
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Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis
By deleting enzymes that affect aerobic glycolysis with different potencies, investigators examined how modulating glucose metabolism specifically affects hematopoietic and leukemic cell populations. [Cell]
Abstract | Graphical Abstract | Press Release
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PUBLICATIONS (Ranked by impact factor of the journal)
Epigenetic Control of Dendritic Cell Development and Fate Determination of Common Myeloid Progenitor by Mysm1
Using a Mysm1 knockout (Mysm1-/-) mouse model, scientists identified the histone H2A deubiquitinase Mysm1 as a critical regulator in dendritic cell (DC) differentiation. Mysm1-/- mice showed a global reduction of DCs in lymphoid organs whereas development of granulocytes and macrophages were not severely affected. [Blood] Abstract

CXCL12+ Stromal Cells as Bone Marrow Niche for CD34+ Hematopoietic Cells and Their Association with Disease Progression in Myelodysplastic Syndromes
Using immunohistochemistry, scientists show that CXCL12+ cells were located in the cellular marrow or perivascular area, and were in contact with CD34+ hematopoietic cells in control and myelodysplastic syndromes/acute myelogenous leukemia with myelodysplasia-related changes bone marrow. [Lab Invest] Abstract

Pre-Transplant Mobilization with Granulocyte Colony Stimulating Factor Improves B Cell Reconstitution by Lentiviral Vector Gene Therapy in SCID-X1 Mice
Researchers hypothesized that mobilization of hematopoietic stem cell by granulocyte colony-stimulating factor should create temporary space in bone marrow niches to improve engraftment and thereby B cell reconstitution. [Hum Gene Ther] Abstract

Characterization of Transcription Factor Networks Involved in Umbilical Cord Blood CD34+ Stem Cells-Derived Erythropoiesis
Investigators utilized umbilical cord blood CD34+ stem cells induced to undergo erythroid differentiation to characterize the transcriptome and transcription factor networks associated with the γ/β-globin switch during fetal erythropoiesis. [PLoS One] Full Article

Vasculogenic and Hematopoietic Cellular Progenitors Are Scattered within the Prenatal Mouse Heart
Scientists characterized phenotypic profiles and location of putative vasculogenic and hematopoietic cellular progenitors in the embryonic mouse heart. [Histochem Cell Biol] Abstract | Full Article


First-Line Treatment for Severe Aplastic Anemia in Children: Bone Marrow Transplantation from a Matched Family Donor vs. Immunosuppressive Therapy
Researchers retrospectively compared the outcomes of children with acquired severe aplastic anemia who received immunosuppressive therapy within prospective trials conducted by the Japan Childhood Aplastic Anemia Study Group or who underwent bone marrow transplantation from an HLA-matched family donor registered in the Japan Society for Hematopoietic Cell Transplantation Registry. [Haematologica]
Abstract | Full Article

Hematological Recovery after Autologous Stem Cell Transplantation Is Associated with Favorable Outcome in Acute Myeloid Leukemia
Investigators analyzed the prognostic significance of hematological recovery for neutrophils and platelets, stratifying at day 20 after autologous stem cell transplantation in 88 consecutive and homogeneously treated acute myeloid leukemia patients in first remission. [Br J Haematol] Abstract

Comparative Analysis of Unrelated Cord Blood Transplantation and HLA-Matched Sibling Hematopoietic Stem Cell Transplantation in Children with High-Risk or Advanced Acute Leukemia
Researchers present a clinical comparison of unrelated cord blood transplantation and human leukocyte antigen (HLA)-matched sibling allogeneic peripheral blood stem cell or bone marrow transplantation in children with high-risk or advanced acute leukemia. [Ann Hematol] Abstract

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Early Lymphoid Lesions: Conceptual, Diagnostic and Clinical Challenges
The authors summarize the diagnostic criteria, recent advances in predicting progression and current recommendations for management of the more recently recognized early or indeterminate clonal lymphoid lesions of B-cell, T-cell and NK-cell derivation. [Haematologica] Full Article

New Generation Dendritic Cell Vaccine for Immunotherapy of Acute Myeloid Leukemia
The authors review their extensive studies on the development of a protocol for the generation of dendritic cells with improved immunogenicity and optimized for the use in cell-based immunotherapy. [Cancer Immunol Immunother] Abstract

Regulation of Hematopoietic Stem Cell Aging by the Small RhoGTPase Cdc42
The authors introduce the canonical set of phenotypes associated with aged HSCs, focus on the novel aging-associated phenotype apolarity caused by elevated activity of the small RhoGTPase in aged HSCs, discuss the role of Cdc42 in hematopoiesis and describe that pharmacological inhibition of Cdc42 activity in aged HSCs results in functionally young and thus rejuvenated HSCs. [Exp Cell Res] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

AABB Annual Meeting Cellular Therapy Workshop
Galena Biopharma Doses First Patient in GALE-401 (Anagrelide Controlled Release) Phase II Clinical Trial
Galena Biopharma, Inc. announced the first patient has been dosed in the GALE-401 Phase II Clinical Trial. The Phase II study will treat patients with elevated platelet counts in myeloproliferative neoplasms including essential thrombocythemia. [Galena Biopharma, Inc.] Press Release

Cleveland BioLabs Announces Approval to Start Phase I Study for Hematopoietic Stem Cell Mobilizer CBLB612 in Russian Federation
Cleveland BioLabs, Inc. announced approval from the Ministry of Health of the Russian Federation to start a Phase I clinical trial with CBLB612, a drug in development for the induction and mobilization of hematopoietic stem cells. [Cleveland BioLabs, Inc.] Press Release

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Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Indian Society of Haematology & Blood Transfusion and Indian Society of Transfusion Medicine Conference 2014 (ISTMH SHTM 2014)
November 6-8, 2014
Hyderabad, India

Visit our events page to see a complete list of events in the hematopoiesis community.
NEW Postdoctoral Position – Regenerative Effects of Some Mutations on Hematopoietic Stem Cells (Istanbul University Institute of Experimental Medicine)

NEW Head of Cellular and Molecular Therapies Laboratory (NHS Blood & Transplant – Oxford)

NEW Head of Cellular and Molecular Therapies Laboratory (NHS Blood & Transplant – Leeds)

Postdoctoral Fellow – Hematopoietic Stem Cells and Signaling Transduction (University of Pennsylvania)

PhD Position – Stem Cells for Anti-Cancer Vγ9Vδ2 T Cells (Free University of Brussels)

Stem Cell Biology Program Director (Blood Research Institute of BloodCenter of Wisconsin)

Assistant or Associate Professor – Stem Cells and Regenerative Medicine (Baylor College of Medicine)

Research Associate – Cancer, Stem Cells, and Immunity Focusing on Membrane Proteins and Signaling Pathways (UT Southwestern Medical Center)

Postdoctoral Positions – Hematopoietic and Induced Pluripotent Stem Cells (Indiana University School of Medicine)

Postdoctoral Positions – Reprogramming and Genetic Engineering Technologies to Develop New Models of Hematopoiesis and Hematopoietic Disorders (Icahn School of Medicine)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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