Volume 5.31 | Aug 19

Hematopoiesis News 5.31 August 19, 2014
Hematopoiesis News
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New Blood: Tracing the Beginnings of Hematopoietic Stem Cells
Hematopoietic stem cells (HSCs) give rise to all other blood cell types, but their development and how their fate is determined has long remained a mystery. Researchers elaborated upon a crucial signaling pathway and the role of key proteins, which may help clear the way to generate HSCs from human pluripotent precursors, similar to advances with other kinds of tissue stem cells. [Press release from the University of California, San Diego School of Medicine discussing online prepublication in Nature] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Hematopoietic Stem Cell Induction by Somite-Derived Endothelial Cells Controlled by meox1
Researchers reveal that somite specification of hematopoietic stem cells occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the zebrafish somite that they have defined as the endotome. [Nature] Abstract | Press Release

Dnmt3a and Dnmt3b Have Overlapping and Distinct Functions in Hematopoietic Stem Cells
Researchers report conditional inactivation of Dnmt3b in hematopoietic stem cells (HSCs) either alone or combined with Dnmt3a deletion. Combined loss of Dnmt3a and Dnmt3b was synergistic, resulting in enhanced HSC self-renewal and a more severe block in differentiation than in Dnmt3a-null cells, whereas loss of Dnmt3b resulted in a mild phenotype. [Cell Stem Cell] Abstract | Graphical Abstract

Tight Regulation of Ubiquitin-Mediated DNA Damage Response by USP3 Preserves the Functional Integrity of Hematopoietic Stem Cells
Investigators generated mice deficient for Ub-specific protease 3 (USP3), a histone H2A deubiquitinating enzyme which negatively regulates ubiquitin-dependent DNA damage response signaling. Notably, USP3 deletion increased the levels of histone ubiquitination in adult tissues, reduced the hematopoietic stem cell reserves over time, and shortened animal life span. [J Exp Med] Abstract

MEIS1 Regulates Early Erythroid and Megakaryocytic Cell Fate
Scientists show that two MEIS1 splice variants are expressed in hematopoietic progenitor cells. Constitutive expression of both directed human hematopoietic progenitors towards a megakaryocyte-erythrocyte progenitor fate. [Haematologica] Abstract | Full Article

Longitudinal Analysis of DNA Methylation in CD34+ Hematopoietic Progenitors in Myelodysplastic Syndrome
Investigators analyzed global DNA methylation in purified CD34+ hematopoietic progenitors from myelodysplastic syndrome patients undergoing multiple rounds of 5-azacytidine treatment. [Stem Cells Transl Med] Abstract

Human Leukocyte Antigen DR Surface Expression on CD14+ Monocytes during Adverse Events after Hematopoietic Stem Cell Transplantation
Scientists hypothesized that human leukocyte antigen DR expression might be similarly altered after hematopoietic stem cell transplantation and during post-transplant complications. [Ann Hematol] Abstract


Impact of Platelet Transfusion on Toxicity and Mortality after Hematopoietic Progenitor Cell Transplantation
A retrospective single-center cohort study was conducted on 522 patients undergoing hematopoietic progenitor cell transplantation. Associations between platelet transfusion events and clinical characteristics with transplant-related outcomes were assessed using univariate and multivariate analysis. [Transfusion] Abstract

Sequential Infusion of Donor Derived Dendritic Cells with Donor Lymphocyte Infusion for Relapsed Hematologic Cancers after Allogeneic Hematopoietic Stem Cell Transplantation
Donor lymphocyte infusion (DLI) is often given to induce a graft-versus-leukemia effect after allogeneic hematopoietic stem cell transplantation. Researchers conducted a Phase I trial testing the co-infusion of dendritic cells followed by donor lymphocyte infusion. [Am J Hematol] Abstract

Effects of Priming with Recombinant Human Granulocyte Colony-Stimulating Factor on Conditioning Regimen for High-Risk Acute Myeloid Leukemia Patients Undergoing HLA-Haploidentical Hematopoietic Stem Cell Transplantation: A Multicenter Randomized Controlled Study in Southwest China
In a multicenter randomized controlled trial in southwestern China, 178 high-risk acute myeloid leukemia patients received HLA-haploidentical hematopoietic stem cell transplantation with conditioning regimens involving recombinant human granulocyte colony-stimulating factor (rhG-CSF) or non-rhG-CSF. [Biol Blood Marrow Transplant] Abstract

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Hierarchical Organization of Fetal and Adult Hematopoietic Stem Cells
The authors summarize recent studies characterizing developmental changes in hematopoietic stem cells, some of the mechanisms that control them, and their potential relevance to understanding age-associated differences in leukemia as well as normal hematopoiesis. [Exp Cell Res] Abstract

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Expression Therapeutics LLC Selects ABL, Inc. to Support Cell Line Development for Hemophilia A Factor VIII Infusion Therapy
Expression Therapeutics LLC together with ABL, Inc. announced an agreement whereby ABL will perform cell line development studies to improve manufacturability and reduce the costs associated with large-scale production of recombinant factor VIII replacement therapy. [Expression Therapeutics LLC (Business Wire)]
Press Release

3SBio Signs Exclusive Patent License Agreement with DiNonA for Leukotuximab
3SBio Inc. announced it has entered into an exclusive license with DiNonA Inc. for the development, manufacturing and marketing of Leukotuximab, an anti JL-1 antibody for acute leukemia, including acute myelocytic leukemia and acute lymphoblastic leukemia, in the territory of Greater China and the Middle East. [3SBio Inc.] Press Release

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National Institutes of Health (United States)

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Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 21st Stem Cell Network Workshop – Bioengineering and Stem Cells
September 23, 2014
Sydney, Australia

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NEW Postdoctoral Fellow – Hematopoietic Stem Cells and Signaling Transduction (University of Pennsylvania School of Medicine)

Postdoctoral Researcher – Hematopoietic Stem Cell Maintenance (Baylor College of Medicine)

Postdoctoral Fellow – Hematopoietic Stem Cells and Signaling Transduction (University of Pennsylvania School of Medicine and Children’s Hospital of Philadelphia)

Postdoctoral Fellow – Hematopoietic Stem Cell Research (University of Leuven)

Postdoctoral Positions – Reprogramming and Genetic Engineering Technologies to Develop New Models of Hematopoiesis and Hematopoietic Disorders (Icahn School of Medicine)

Senior Research Fellow/Research Fellow – Hematopoietic and Leukemia Stem Cell Biology (Monash University)

Postdoctoral Position – Molecular Properties of Leukemic Stem Cells (BC Cancer Agency)

Postdoctoral Research Fellow – Molecular Mechanisms Regulating Transformation and Maintenance of Leukemia Stem Cells (City of Hope)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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