Instruction of Hematopoietic Lineage Choice by Cytokine Signaling|
Signal transduction pathways activated by different cytokine receptors are highly overlapping, but support the production of distinct hematopoietic lineages. Cellular context, signaling dynamics, and the crosstalk of different signaling pathways determine the cellular response of a given extrinsic signal. [Exp Cell Res] Abstract
Biophysical Regulation of Hematopoietic Stem Cells
This review sheds light on the role of biophysical parameters in hematopoietic stem cell (HSC) biology and outlines which knowledge on biophysical regulation identified in other cell types could be applied to HSCs. [Biomater Sci] Abstract
Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.
China Cord Blood Corporation and Cordlife Group Limited Announce Collaboration to Aid Asia-Based Patients with Cord Blood Stem Cell Therapy|
China Cord Blood Corporation and Cordlife Group Limited announced that the two companies have joined forces in assisting patients across the PRC, Singapore, Hong Kong, Indonesia, India, the Philippines and Malaysia to identify suitable cord blood matching units for stem cell therapy. [China Cord Blood Corporation] Press Release
Innate Pharma SA Announces Completion of Target Enrollment in the Phase II EffiKIR Trial
Innate Pharma SA announced completion of target enrollment in the EffiKIR trial with 150 patients randomized. EffiKIR is a double-blind placebo-controlled randomized Phase II trial of lirilumab as maintenance treatment in elderly patients with Acute Myeloid Leukemia in first complete remission. [Innate Pharma SA] Press Release
Merck Initiates Phase III Study of Letermovir, an Investigational Antiviral for Prevention of Cytomegalovirus (CMV) Infection in High-Risk Bone Marrow Transplant Patients
Merck announced that the first patient has been enrolled in a global Phase III clinical study of letermovir (MK-8228), an investigational antiviral agent. The multicenter, randomized, placebo-controlled study will evaluate the efficacy and safety of letermovir for the prevention of clinically-significant CMV infection in adult CMV-seropositive recipients of allogeneic hematopoietic stem cell transplants. [Merck & Co., Inc.] Press Release
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