Volume 5.27 | Jul 22

Hematopoiesis News 5.27 July 22nd, 2014
Hematopoiesis News
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Acute Myelogenous Leukemia-Induced Sympathetic Neuropathy Promotes Malignancy in an Altered Hematopoietic Stem Cell Niche
Researchers found that neuropathy of the sympathetic nervous system promotes leukemic bone marrow infiltration in an MLL-AF9 acute myelogenous leukemia model. [Cell Stem Cell] Abstract | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
HSV-sr39TK Positron Emission Tomography and Suicide Gene Elimination of Human Hematopoietic Stem Cells and Their Progeny in Humanized Mice
Scientists demonstrate the in vivo generation of functional effector T-cells from CD34-enriched human peripheral blood stem cells modified with a lentiviral vector designed for clinical use encoding a T-cell-receptor recognizing the cancer/testes antigen NY-ESO-1, co-expressing the PET/suicide gene sr39TK. [Cancer Res] Abstract

DOCK2 Is Critical for CD8+ TCR Graft Facilitating Cells to Enhance Engraftment of Hematopoietic Stem and Progenitor Cells
Dedicator of cytokinesis 2 (DOCK2)-/- facilitating cells exhibit compromised facilitative function in vivo as evidenced by the loss of engraftment-enhancing capability for c-Kit+Sca-1+lineage (KSL) cells, and compromised ability to promote KSL cell homing and lodgment in hematopoietic niche. [Stem Cells] Abstract

LincRNAs MONC and MIR100HG Act as Oncogenes in Acute Megakaryoblastic Leukemia
Researchers report that long non-coding RNAs MONC and MIR100HG are highly expressed in acute megakaryoblastic leukemia blasts. The transcripts were mainly localized in the nucleus and their expression correlated with the corresponding microRNA clusters. [Mol Cancer] Abstract | Full Article

Diet-Induced (Epigenetic) Changes in Bone Marrow Augment Atherosclerosis
Scientists investigated the long-term changes induced by Western-type diet (WTD) feeding on BM cells and the consequences for atherosclerosis susceptibility. Hereto, WTD BM or Chow BM was transplanted into LDLR KO mice on chow. BM from WTD BM recipient mice exhibited hypomethylation of CpG regions in the genes encoding Pu.1 and IRF8, key regulators of monocyte proliferation and macrophage differentiation. [J Leukoc Biol] Abstract

Dietary Restriction Ameliorates Hematopoietic Aging Independent of Telomerase, whilst Lack of Telomerase and Short Telomeres Exacerbate the Aging Phenotype
To investigate the role of telomeres and telomerase in hematopoietic aging, investigators compared the hematopoietic stem and progenitor cell profile and clonogenic capacity of bone marrow cells from wild type with telomerase-deficient mice and the effect of dietary restriction on these parameters. [Exp Gerontol] Abstract


The EBMT/EMCL Consensus Project on the Role of Autologous and Allogeneic Stem Cell Transplantation in Mantle Cell Lymphoma
Investigators conducted a consensus project using the RAND modified Delphi consensus procedure to provide guidance on how stem cell transplantation should be employed in mantle cell lymphoma. [Leukemia] Abstract

Chromosome 1 Abnormalities in Newly Diagnosed Elderly Multiple Myeloma Patients Treated with Novel Therapies
Researchers investigated the impact of chromosome 1 abnormalities in a group of elderly newly diagnosed Multiple Myeloma patients, enrolled in the GIMEMA-MM-03-05 trial and treated with bortezomib, melphalan and prednisone vs bortezomib, melphalan, prednisone and thalidomide followed by bortezomib and thalidomide maintenance. [Haematologica] Abstract | Full Article

Allogeneic Hematopoietic SCT in Combination with Tyrosine Kinase Inhibitor Treatment Compared with TKI Treatment Alone in CML Blast Crisis
Of 83 CML blast crisis patients, 45 received tyrosine kinase inhibitors (TKIs) (imatinib; nilotinb or dasatinib after imatinib resistance) and 38 were treated with allo-HSCT after TKI. [Bone Marrow Transplant] Abstract

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Stem Cells, Megakaryocytes, and Platelets
The authors reviewed the optimization of megakaryocyte and platelet differentiation and discuss the mechanistic studies and disease models that have incorporated stem cell technologies. [Curr Opin Hematol] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

3rd Annual Cell Culture & Bioprocessing Congress
Sorrento Awarded Grant from the National Institutes of Health for the Development of a Small Molecule Myc Inhibitor
Sorrento Therapeutics, Inc. announced that it has received non-dilutive funding for the preclinical development of a small molecule inhibitor targeting the important oncogenic transcription factor Myc. Abnormal Myc activity is believed to play a substantial role in at least one out of every seven cancer deaths and is often a key factor in breast, lung, colon, hematologic, and other cancers. [Sorrento Therapeutics, Inc.] Press Release

Synta Announces Advancement of Ganetespib into Phase III Extension of AML LI-1 Study for Patients with AML and High-Risk MDS
Synta Pharmaceuticals Corp. announced the advancement of ganetespib into the Phase III extension of the AML LI-1 (less intensive) trial. AML LI-1 is a multicenter, randomized Phase II/III clinical study evaluating several novel treatment regimens, including the combination of ganetespib with low dose cytarabine, in newly diagnosed elderly patients with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) who are not eligible for intensive chemotherapy. [Synta Pharmaceuticals Corp.] Press Release

ERYTECH Announces Enrollment of First Patient in Phase I/II Study of ERY-ASP in Acute Lymphoblastic Leukemia in the United States
ERYTECH Pharma announced the enrollment of the first patient in its Phase I/II study with ERY-ASP in acute lymphoblastic leukemia in the United States of America. [ERYTECH Pharma] Press Release

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NEW Translational Regenerative Medicine Congress 2014
October 21-23, 2014
Leipzig, Germany

Visit our events page to see a complete list of events in the hematopoiesis community.
NEW Product Marketing Manager (Cesca Therapeutics)

NEW Senior Research Fellow/Research Fellow – Hematopoietic and Leukemia Stem Cell Biology (Monash University)

Postdoctoral Position – Molecular Properties of Leukemic Stem Cells (BC Cancer Agency)

Postdoctoral Research Fellow – Molecular Mechanisms Regulating Transformation and Maintenance of Leukemia Stem Cells (City of Hope)

PhD Student – Development and Regulation of Innate Immunity (Lund University)

Biologist – Hypoxia Signaling in Myeloproliferative Neoplasms (University Hospital Aachen)

Research Associate – Transcriptional/Epigenetic Changes and Their Roles in Normal and Malignant Hematopoietic Stem Cell Development (King’s College London)

Scientific Manager – hES and iPS Cell Lines to Model Normal Hematopoiesis and Related Blood Diseases (St. Jude Children’s Research Hospital)

Postdoctoral Research Fellow – Cardiovascular Immunology / Hematology (Massachusetts General Hospital)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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