Volume 5.22 | Jun 10

Hematopoiesis News 5.22 June 10, 2014
Hematopoiesis News
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Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression
Scientists showed that prolonged fasting reduces circulating IGF-1 levels and PKA activity in various cell populations, leading to signal transduction changes in long-term hematopoietic stem cells and niche cells that promote stress resistance, self-renewal, and lineage-balanced regeneration. [Cell Stem Cell]
Abstract | Graphical Abstract | Press Release
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PUBLICATIONS (Ranked by impact factor of the journal)

Survivin Modulates Genes with Divergent Molecular Functions and Regulates Proliferation of Hematopoietic Stem Cells through Evi-1
While investigating conditional Survivin deletion in mice, investigators found that Survivin was highly expressed in phenotypically defined hematopoietic stem cells (HSCs) and Survivin deletion in mice resulted in significantly reduced total marrow HSC and progenitor cells. [Leukemia] Abstract

Engineering Human Tumor Associated Chromosomal Translocations with the RNA-Guided CRISPR-Cas9 System
The authors presented a strategy for generating cancer-related human chromosomal translocations in vitro based on the ability of the RNA-guided CRISPR-Cas9 system to induce double-strand breaks at defined positions. Using this approach they generated human cell lines and primary cells bearing chromosomal translocations resembling those described in acute myeloid leukemia and Ewing’s sarcoma at high frequencies. [Nat Commun] Abstract | Press Release

NrasG12D Oncoprotein Inhibits Apoptosis of Pre-Leukemic Cells Expressing Cbfβ-SMMHC via Activation of MEK/ERK Axis
Investigators used NrasLSL-G12D; Cbfb56M knock-in mice to show that allelic expression of oncogenic NrasG12D and Cbfβ-SMMHC increases survival of pre-leukemic short-term hematopoietic stem cells and myeloid progenitor cells and maintains the differentiation block induced by the fusion protein. [Blood] Abstract

Reduced Expression of CD18 Leads to the In Vivo Expansion of Hematopoietic Stem Cells in Mouse Bone Marrow
To investigate the role of CD18 in hematopoietic stem cell (HSC) biology, researchers thoroughly characterized the HSCs of CD18 Itgb2tm1bay hypomorphic mice both by flow cytometry and using in vitro and in vivo transplantation assays. [Stem Cells] Abstract

Gene Profiling Reveals Association between Altered Wnt Signaling and Loss of T-Cell Potential with Age in Human Hematopoietic Stem Cells
Investigators examined the gene expression profiles of young and aged hematopoietic stem cells (HSCs) from human cord blood and adult mobilized peripheral blood, respectively, and found that Wnt signaling genes are differentially expressed between young and aged human HSCs, with less activation of Wnt signaling in aged HSCs. [Aging Cell] Full Article

Dynamic Equilibrium of Heterogeneous and Interconvertible Multipotent Hematopoietic Cell Subsets
Scientists describe extensive phenotypic and functional heterogeneity of EML cells which stems from the coexistence of multiple cell subsets. Each of these subsets is phenotypically and functionally heterogeneous, and displays distinct multilineage differentiation potential, cell cycle profile, proliferation kinetics, and expression pattern of hematopoietic stem cell markers and some of the key lineage-associated transcription factors. [Sci Rep] Full Article


Early Use of Allogeneic Hematopoietic Stem Cell Transplantation for Infants with MLL Gene-Rearrangement-Positive Acute Lymphoblastic Leukemia
Sixty-two infants with MLL gene-rearrangement-positive acute lymphoblastic leukemia were treated with the MLL03 protocol of the Japanese Pediatric Leukemia/Lymphoma Study Group: short-course intensive chemotherapy followed by early allogeneic hematopoietic stem cell transplantation within four months of the initial induction. [Leukemia] Abstract

Factors Predicting Hematopoietic Recovery in Patients Undergoing Autologous Transplantation: 11-Year Experience from a Single Center
Investigators evaluated 446 consecutive patients who underwent autologous transplantation at our center between 2001 and 2012. The impact of pre-transplant and collection factors together with CD34+ dosing ranges on engraftment, hospital length of stay and survival endpoints were assessed in order to identify factors which might be optimized to improve outcomes for patients undergoing autologous transplantation using hematopoietic progenitor cells-apheresis. [Ann Hematol] Abstract

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Hematopoietic Stem Cell Aging
Researchers summarize current aspects on cellular and molecular mechanisms that are associated with aging of hematopoietic stem cells, the role of the stem cell niche for stem cell aging as well as novel and encouraging experimental approaches to attenuate aging of hematopoietic stem cells to target immunosenescence. [Curr Opin Immunol] Abstract

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Accelerate Your Cell Therapy to Market
ScinoPharm to Provide Active Pharmaceutical Ingredient to TaiGen for Novel Stem Cell Drug
ScinoPharm Taiwan, Ltd. and TaiGen Biotechnology jointly announced the signing of a manufacturing contract for the clinical supply of the API of Burixafor, a new chemical entity discovered and developed by TaiGen. Burixafor is a novel stem cell mobilizer that can efficiently mobilize bone marrow stem cells and tissue precursor cells to the peripheral blood. It can be used in hematopoietic stem cell transplantation, chemotherapy sensitization and other ischemic diseases. [ScinoPharm Taiwan, Ltd.] Press Release

MEI Pharma Reports High Response Rates in Phase II Study of Pracinostat in Front Line Acute Myeloid Leukemia
MEI Pharma, Inc. announced preliminary response data from the first stage of a two-stage, open-label Phase II clinical study of its investigational drug candidate Pracinostat in combination with Vidaza® in elderly patients with newly diagnosed acute myeloid leukemia who are unsuitable for intensive chemotherapy. [MEI Pharma, Inc.] Press Release

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NEW South Central Association of Blood Banks & Association of Donor Recruitment Professionals Joint Educational Symposium
July 18, 2014
Fort Worth, United States

NEW World Alliance Forum in San Francisco – The Impact of Regenerative Medicine 2014
November 6-7, 2014
San Francisco, United States

NEW The World Stem Cell Summit 2014
December 3-5, 2014
San Antonio, United States

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NEW Research Associate – Hematopoietic and Leukemic Stem Cells (Shanghai Jiao-Tong University School of Medicine)

Postdoctoral Position/Clinical Pharmacist – Hematopoiesis and Laboratory for Cell Therapy (Sanquin)

Clinical HSCT Faculty Position – Pediatric Hematology-Oncology (University of Wisconsin School of Medicine)

Postdoctoral Research Scientist – Stem Cell Biology and Cellular Immunology (The Anthony Nolan Trust)

Postdoctoral Fellow – Mammalian Hematopoietic and Erythroid Development (Icahn School of Medicine at Mount Sinai)

Postdoctoral Fellow – Regulation of Cytokine Receptor Signaling in Hematopoietic Stem Cells (University of Pennsylvania School of Medicine)

Postdoctoral Positions – New Models of Hematopoiesis and Hematopoietic Disorders (Icahn School of Medicine at Mount Sinai)

Postdoctoral Researcher – Cancer Genomics (University of Chicago)

Postdoctoral Associate – Hematopoietic Differentiation (Northwestern University Feinberg School of Medicine)

Postdoctoral Fellowship – Hematology, Immunology, Cancer Therapeutics (Nationwide Children’s Hospital)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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