Volume 5.20 | May 27

Hematopoiesis News 5.20 May 27, 2014
Hematopoiesis News
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Genomic Landscape of CD34+ Hematopoietic Cells in Myelodysplastic Syndrome and Gene Mutation Profiles as Prognostic Markers
Whole-genome sequencing was performed in CD34+ hematopoietic stem/progenitor cells from eight cases of refractory anemia with excess blasts, the high-risk subtype of myelodysplastic syndrome. The nucleotide substitution patterns were found similar to those reported in acute myeloid leukemia, and mutations of 96 protein-coding genes were identified. [Proc Natl Acad Sci USA] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

In Vivo Time-Lapse Imaging of Mouse Bone Marrow Reveals Differential Niche Engagement by Quiescent and Naturally Activated Hematopoietic Stem Cells
Investigators used a natural mouse parasite, Trichinella spiralis, and multi-point intravital time-lapse confocal microscopy of mouse calvarium bone marrow to test whether hematopoietic stem cell-niche interactions may change when hematopoiesis is perturbed. [Blood] Abstract

CBFβ and RUNX1 Are Required at Two Different Steps during the Development of Hematopoietic Stem Cells in Zebrafish
Researchers generated and characterized two zebrafish cbfb null mutants. The cbfb-/- embryos underwent primitive hematopoiesis and developed transient erythromyeloid progenitors, but they lacked definitive hematopoiesis. [Blood] Abstract

Antigenic-Sheltering Universal Red Blood Cells by Polydopamine-Based Cell Superficial-Engineering
Inspired by the adhesive proteins secreted by mussels, scientists suggest a catecholic chemistry-based strategy to shelter antigenic epitopes on red blood cells (RBCs) by using polydopamine, which can guard against coagulation reaction without other negative effects on the RBCs structure, function and viability. [Chem Sci] Abstract | Press Release

SIGLEC-G Deficiency Increases Susceptibility to Develop B-Cell Lymphoproliferative Disorders
The authors studied the B-lymphocyte fate in Siglecg-/- mice over time. They demonstrated that in aging animals SIGLEC-G deficiency promotes the progressive accumulation of monoclonal B lymphocytes and increases the susceptibility to develop B-cell lymphoproliferative disorders. [Haematologica] Abstract | Full Article

Rapid Reconstitution of Functionally Active 6-sulfoLacNAc+ Dendritic Cells (slanDCs) of Donor Origin following Allogeneic Hematopoietic Stem Cell Transplant
Investigators analyzed slanDCs, a subset of human proinflammatory dendritic cells, in hematopoietic stem cell (HSC) sources, and evaluated their one-year kinetics of reconstitution, origin and functional capacities in peripheral blood and bone marrow of patients who have undergone HSC transplant, and their presence in graft versus host disease tissue-specimens. [Clin Exp Immunol] Abstract

Identification of Hematopoietic-Specific Regulatory Elements from the CD45 Gene and Use for Lentiviral Tracking of Transplanted Cells
Researchers report that the protein tyrosine phosphatase CD45 is an ideal candidate gene on which to base a hematopoietic reporter. CD45 regulatory elements were discovered by analyzing transcription factor chromatin occupancy and promoter nuclease sensitivity to identify minimally sufficient sequences required for expression. [Exp Hematol] Abstract

RepSox Slows Decay of CD34+ Acute Myeloid Leukemia Cells and Decreases T Cell Immunoglobulin Mucin-3 Expression
This study sought to advance development of leukemic stem/progenitor cell-targeted therapies by exploring nongenetic ways to slow the decay and to increase the immunogenicity of primary CD34+ acute myeloid leukemia cells. [Stem Cells Transl Med] Abstract


Increased Mitochondrial Apoptotic Priming of Human Regulatory T Cells after Allogeneic Hematopoietic Stem Cell Transplantation
Quantitation of mitochondrial apoptotic priming was used to compare susceptibility of regulatory T cells, conventional CD4 T cells and CD8 T cells to intrinsic pathway apoptosis in 57 patients after allogeneic hematopoietic stem cell transplantation and 25 healthy donors. [Haematologica] Abstract | Full Article

A Pilot Phase I Dose Finding Safety Study of the Thrombopoietin-Receptor Agonist, Eltrombopag, in Patients with Myelodysplastic Syndrome Treated with Azacitidine
This Phase I clinical trial was designed to explore the safety and tolerability of combining eltrombopag with Azacitidine in patients with myelodysplastic syndromes. In addition, the investigators assessed the potential effects of eltrombopag on hematopoietic stem and progenitor cells from included patients. [Eur J Haematol] Abstract

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Kit and Scl Regulation of Hematopoietic Stem Cells
KIT signaling in hematopoietic stem cells (HSCs) involves effectors such as SHP2 and PTPN11. This review summarizes the recent developments on the novel mechanisms regulating or reinforcing KIT signal strength in HSCs and its perturbation in polycythemia vera. [Curr Opin Hematol] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.
NCCN Receives $2 Million in Research Funding from Boehringer Ingelheim to Study Volasertib in Hematologic Malignancies
The National Comprehensive Cancer Network® (NCCN®) Oncology Research Program has been awarded a $2-million grant from Boehringer Ingelheim Pharmaceuticals, Inc. to develop a program to scientifically evaluate and define the safety and clinical effectiveness of the investigational compound volasertib in the treatment of hematologic malignancies. [National Comprehensive Cancer Network] Press Release

UCL, Imperial & Cell Therapy Catapult Collaborate to Advance Leukemia Cell Therapy
A novel cell therapy approach to the treatment of acute myeloid leukemia is to be developed further via an innovative partnership between the Cell Therapy Catapult, UCL Business and Imperial Innovations. [Cell Therapy Catapult] Press Release

Stem Cell Research on Campus Grows after $3 Million Boost
Cornell Stem Cell Program researchers Professor John Schimenti and Nikitin received $3 million from the New York State Stem Cell Science program of the New York State Department of Health to support the Stem Cell Modeling and Phenotyping Core. [Cornell University] Press Release

Maryland Stem Cell Research Commission Funds 31 New Research Proposals in FY 2014 with Continued Focus on Contributing to Cures for Debilitating Diseases and Conditions
The board of directors of the Maryland Technology Development Corporation approved the Maryland Stem Cell Research Commission’s recommendation to fund 31 new proposals with the Maryland Stem Cell Research Fund’s $10.4 million FY2014 budget. [Maryland Stem Cell Research Commission] Press Release

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European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Beatson International Cancer Conference
July 6-9, 2014
Glasgow, United Kingdom

Visit our events page to see a complete list of events in the hematopoiesis research community.
NEW Clinical HSCT Faculty Position – Pediatric Hematology-Oncology (University of Wisconsin School of Medicine)

NEW Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Research Scientist – Stem Cell Biology and Cellular Immunology (The Anthony Nolan Trust)

Postdoctoral Fellow – Mammalian Hematopoietic and Erythroid Development (Icahn School of Medicine at Mount Sinai)

Postdoctoral Fellow – Regulation of Cytokine Receptor Signaling in Hematopoietic Stem Cells (University of Pennsylvania School of Medicine)

Postdoctoral Positions – New Models of Hematopoiesis and Hematopoietic Disorders (Icahn School of Medicine at Mount Sinai)

Postdoctoral Researcher – Cancer Genomics (University of Chicago)

Postdoctoral Fellow in Cardiovascular Immunology / Hematology (Massachusetts General Hospital)

Postdoctoral Associate – Hematopoietic Differentiation (Northwestern University Feinberg School of Medicine)

Postdoctoral Fellowship – Hematology, Immunology, Cancer Therapeutics (Nationwide Children’s Hospital)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Research Technologist – hPSC (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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