Volume 5.18 | May 13

Hematopoiesis News 5.18 May 13, 2014
Hematopoiesis News
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RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis
Scientists showed that C57BL/6 Ripk1-/- mice die at birth of systemic inflammation that was not transferable by the hematopoietic compartment. However, Ripk1-/- progenitors failed to engraft lethally irradiated hosts properly. Blocking tumor necrosis factor reversed this defect in emergency hematopoiesis but, surprisingly, Tnfr1 deficiency did not prevent inflammation in Ripk1-/- neonates. [Cell]
Abstract | Graphical Abstract | Press Release
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PUBLICATIONS (Ranked by impact factor of the journal)

Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle
Investigators quantified DNA damage in hematopoietic stem cells (HSCs) and downstream progenitors from young and old mice, revealing that strand breaks significantly accrue in HSCs during aging. [Cell Stem Cell] Abstract | Graphical Abstract

Clonal Variegation and Dynamic Competition of Leukemia-Initiating Cells in Infant Acute Lymphoblastic Leukemia with MLL Rearrangement
Through Ig/TCR rearrangement analysis of mixed lineage leukemia (MLL)-AF4+ infant acute lymphoblastic leukemia (ALL) at diagnosis and xenograft leukemias from mice transplanted with the same diagnostic samples, scientists established that MLL-AF4+ infant ALL is composed of a branching subclonal architecture already at diagnosis, frequently driven by a Ig/TCR-rearranged founder clone. [Leukemia] Abstract

Mapping Hematopoiesis in a Fully Regenerative Vertebrate: The Axolotl
The authors used white and CMV:GFP+ transgenic white axolotl strains to map sites of hematopoiesis and develop hematopoietic cell transplant methodology. They also established a FACS enrichment technique for major blood lineages and colony-forming unit assays for hematopoietic progenitors. [Blood] Abstract

Deficiency of the NR4A Orphan Nuclear Receptor NOR1 in Hematopoietic Stem Cells Accelerates Atherosclerosis
Investigators employed bone marrow transplantation to determine the selective contribution of NOR1 expression in hematopoietic stem cells to the development of atherosclerosis. [Stem Cells] Abstract

Engineering the Human Thymic Microenvironment to Support Thymopoiesis In Vivo
Scientists developed an implantable thymic microenvironment composed of two human thymic stroma populations critical for thymopoiesis; thymic epithelial cells and thymic mesenchyme. [Stem Cells] Abstract

The Histone Methyltransferase Activity of MLL1 Is Dispensable for Hematopoiesis and Leukemogenesis
Scientists showed that the SET domain, and thus histone methyltransferase activity of MLL1, is dispensable for maintaining hematopoietic stem cells and supporting leukemogenesis driven by the MLL-AF9 fusion oncoprotein. [Cell Rep] Full Article | Graphical Abstract | Press Release


Hematopoietic SCT: A Useful Treatment for Late Metachromatic Leukodystrophy
Allogeneic hematopoietic SCT (HSCT) is currently the only treatment for adult and late-onset juvenile metachromatic leukodystrophy (MLD), although it is still in question because of insufficient follow-up. Investigators aimed to determine whether HSCT could halt the progression of adult and late-onset juvenile MLD. [Bone Marrow Transplant] Abstract

Combined Umbilical Cord Blood and Bone Marrow from HLA-Identical Sibling Donors for Hematopoietic Stem Cell Transplantation in Children with Hemoglobinopathies
Investigators analyzed the feasibility and outcome of hematopoietic stem cell transplantation in 13 children with hemoglobinopathies after the co- infusion of cord blood and bone marrow from the same human leucocyte antigen (HLA) identical sibling donor. [Pediatr Blood Cancer] Abstract

How Ex Vivo Models Drive Progress in HIV Research: Read the Research Profiles
RNA Interference Screening to Detect Targetable Molecules in Hematopoietic Stem Cells
The authors discuss how RNA interference screening has emerged as a new and powerful tool to molecularly dissect various functional aspects of both normal and malignant hematopoietic stem cells, and how this may ultimately enable the discovery of novel therapeutic targets for clinical applications. [Curr Opin Hematol] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

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Epizyme Initiates Pediatric MLL-r Proof-of-Concept Study for EPZ-5676
Epizyme, Inc. EPZM announced the initiation of a Phase Ib open-label clinical study of EPZ-5676 in pediatric patients with acute leukemias bearing a rearrangement of the MLL gene (MLL-r). [Epizyme, Inc.] Press Release

Immunomedics Announces U.S. Patent for IMMU-114
Immunomedics, Inc. announced the issuance of U.S. patent no. 8,722,047 for the company’s patent application “Humanized anti-HLA-DR antibodies.” The allowed claims protect IMMU-114, which is being investigated as a monotherapy in a newly-opened Phase I dose-escalation trial in patients with relapsed or refractory non-Hodgkin lymphoma or chronic lymphocytic leukemia. [Immunomedics, Inc.] Press Release

STEMCELL Technologies Inc. Has Just Released NEW MesenCult™ Proliferation Kit with MesenPure™ (Mouse), a Novel Cell Culture Medium to Advance Research on Mouse Mesenchymal Stem and Progenitor Cells (MSCs)
MesenCult™ Proliferation Kit with MesenPure™ (Mouse) is a novel cell culture medium to advance research on mouse mesenchymal stem and progenitor cells (MSCs). [STEMCELL Technologies Inc.] Press Release

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NEW Hematologic Malignancies: Translating Discoveries to Novel Therapies
September 20 – 23, 2014
Philadelphia, United States

Visit our events page to see a complete list of events in the hematopoiesis research community.
NEW Postdoctoral Fellow – Mammalian Hematopoietic and Erythroid Development (Icahn School of Medicine at Mount Sinai)

NEW Postdoctoral Fellow – Regulation of Cytokine Receptor Signaling in Hematopoietic Stem Cells (University of Pennsylvania School of Medicine)

NEW Postdoctoral Positions – New Models of Hematopoiesis and Hematopoietic Disorders (Icahn School of Medicine at Mount Sinai)

Postdoctoral Researcher – Cancer Genomics (University of Chicago)

Postdoctoral Fellow in Cardiovascular Immunology / Hematology (Massachusetts General Hospital)

Postdoctoral Associate – Hematopoietic Differentiation (Northwestern University Feinberg School of Medicine)

Postdoctoral Fellowship – Hematology, Immunology, Cancer Therapeutics (Nationwide Children’s Hospital)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Research Technologist – hPSC (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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