Volume 5.17 | May 6

Hematopoiesis News 5.17 May 6, 2014
Hematopoiesis News
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The Unfolded Protein Response Governs Integrity of the Hematopoietic Stem-Cell Pool during Stress
Scientists showed that human hematopoietic stem cells are predisposed to apoptosis through strong activation of the PERK branch of the unfolded protein response after endoplasmic reticulum stress, whereas closely related progenitors exhibit an adaptive response leading to their survival. [Nature] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

Rare and Low-Frequency Coding Variants in CXCR2 and Other Genes Are Associated with Hematological Traits
To test the effects of rare and low-frequency coding variants on hematological traits, researchers analyzed hemoglobin concentration, hematocrit levels, white blood cell counts and platelet counts in 31,340 individuals genotyped on an exome array. [Nat Med] Abstract

Bone Marrow-on-a-Chip Replicates Hematopoietic Niche Physiology In Vitro
Scientists describe a method for fabricating ‘bone marrow-on-a-chip’ that permits culture of living marrow with a functional hematopoietic niche in vitro by first engineering new bone in vivo, removing it whole and perfusing it with culture medium in a microfluidic device. [Nat Method] Abstract

Loss of β-Catenin Triggers Oxidative Stress and Impairs Hematopoietic Regeneration
Using Wnt reporter mice, scientists showed that radiation triggers activation of Wnt signaling in hematopoietic stem and progenitor cells. β-Catenin-deficient mice, which lack the ability to activate canonical Wnt signaling, exhibited impaired hematopoietic stem cell regeneration and bone marrow recovery after radiation. [Genes Dev] Abstract | Press Release

Functional and Molecular Features of the Calmodulin-Interacting Protein IQCG Required for Hematopoiesis in Zebrafish
Investigators used zebrafish to investigate the role of iqcg in hematopoietic development, and find that the numbers of hematopoietic stem cells and multilineage-differentiated cells are reduced in iqcg-deficient embryos. [Nat Commun] Abstract

Post-Transcriptional Regulation of c-Myc Expression in Adult Murine HSCs during Homeostasis and Interferon-α Induced Stress Response
Scientists showed that hematopoietic stem cells (HSCs) and more committed progenitors express similar levels of c-myc transcripts. Using knock-in mice expressing a functional eGFP-c-Myc fusion protein under control of the endogenous c-myc locus, c-Myc protein levels were assessed. [Blood] Abstract

Integrated Genetic Approaches Identify the Molecular Mechanisms of Sox4 in Early B Cell Development: Intricate Roles for RAG1/2 and CK1ϵ
The authors used integrated genetic approaches and systematically determined the role of Sox4 and the underlying molecular mechanisms in early B cell development. They found that Sox4 coordinates multilevel controls in the differentiation of early-stage B cells. [Blood] Abstract


Sensitivity of Hematological Malignancies to Graft-versus-Host Effects: An EBMT Megafile Analysis
In chronic myeloid leukemia (CML), the relapse risk declined clearly and proportionally to severity of acute and chronic graft-versus-host disease (GvHD). Acute lymphoblastic leukemia and BCR-ABL negative myeloproliferative neoplasias were comparably sensitive to GvHD as CML, whereas myelodysplastic syndromes and lymphoproliferative disorders showed intermediate sensitivity. [Leukemia] Abstract

Allogeneic Stem Cell Transplantation for Mantle Cell Lymphoma – Final Report from the Prospective Trials of the East German Study Group Hematology/Oncology (OSHO)
Investigators evaluated allogeneic stem cell transplantation (alloSCT) as consolidation for patients with mantle cell lymphoma. Thirty-three of 39 patients underwent alloSCT after myeloablative or toxicity-reduced conditioning. [Ann Hematol] Abstract

Take the "if" out of "diff": Reduce variability when differentiating to hematopoietic cells
Possible Implication of Bacterial Infection in Acute Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation
The authors review the literature addressing the interactions of bacterial infections and graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. [Front Oncol] Abstract

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Stem Cells and Regen Med Asia 2014
Actinium Announces Start of Collaboration to Manufacture Iomab™-B for Phase III Clinical Trial and Commercialization
Actinium Pharmaceuticals, Inc. announced that it made further steps towards centralized current good manufacturing practice (cGMP) manufacturing of its lead drug candidate Iomab™-B. Iomab™-B is being developed to enable bone marrow transplants in patients affected by relapsed and refractory acute myeloid leukemia. [Actinium Pharmaceuticals, Inc.] Press Release

PIXUVRI® Launched in UK for Adult Patients with Multiply Relapsed or Refractory Aggressive B-Cell Non-Hodgkin Lymphoma
Cell Therapeutics, Inc. announced the launch of PIXUVRI® (pixantrone), the first new treatment for adult patients in the United Kingdom (UK) with multiply relapsed or refractory aggressive B-cell non-Hodgkin lymphoma. [Cell Therapeutics, Inc.] Press Release

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NEW Postdoctoral Researcher – Cancer Genomics (University of Chicago)

NEW Research Technologist – hPSC (STEMCELL Technologies Inc.)

Postdoctoral Fellow in Cardiovascular Immunology / Hematology (Massachusetts General Hospital)

Postdoctoral Associate – Hematopoietic Differentiation (Northwestern University Feinberg School of Medicine)

Postdoctoral Fellowship – Hematology, Immunology, Cancer Therapeutics (Nationwide Children’s Hospital)

Postdoctoral Position – Development of Novel Treatment for Mixed Lineage Leukemia (Oslo University Hospital)

Research Associate – Hematology/Oncology (University of Chicago)

Postdoctoral Position – Immunotherapies for Cancer Based on Genetic Engineered T Lymphocytes and/or Hematopoietic Stem Cells (Roswell Park Cancer Institute)

Postdoctoral Fellow – Mammalian Hematopoietic and Erythroid Development (The Icahn School of Medicine at Mount Sinai)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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