Volume 5.09 | Mar 11

Hematopoiesis News 5.09 March 11, 2014
Hematopoiesis News
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Stem Cell Study Opens Door to Undiscovered World of Biology
For the first time, researchers showed that an essential biological process known as protein synthesis can be studied in adult stem cells – something scientists have long struggled to accomplish. The groundbreaking findings also demonstrate that the precise amount of protein produced by blood-forming stem cells is crucial to their function. [Press release from the Children’s Medical Center Research Institute at UT Southwestern discussing online prepublication in Nature] Press Release | Abstract
NEW STEMvision CB, BM & MPB Algorithms
PUBLICATIONS (Ranked by impact factor of the journal)

Circulating Hematopoietic Stem and Progenitor Cells Are Myeloid-Biased in Cancer Patients
Researchers showed, in detailed studies of the peripheral blood from 133 untreated patients with seven different types of tumors, that the composition of circulating hematopoietic stem and progenitor cells was significantly altered in patients with solid tumors. [Proc Natl Acad Sci USA] Abstract

Efficacy against Human Acute Myeloid Leukemia and Myeloablation of Normal Hematopoiesis in a Mouse Model Using Chimeric Antigen Receptor-Modified T Cells
Scientists showed that CD123 is a good target for acute myeloid leukemia (AML)-directed chimeric antigen receptor therapy, as its expression increases over time in vivo even in initially CD123dim populations, and that human CD123-redirected T cells eradicate primary AML in immunodeficient mice. [Blood] Abstract

Donor Hematopoiesis in Mice Following Total Lymphoid Irradiation Requires Host T Regulatory Cells for Durable Engraftment
Total lymphoid irradiation is reported to increase the frequency of regulatory CD4+CD25+FoxP3+ T cells relative to conventional T cells. Barriers to hematopoietic stem cell engraftment following this non-myeloablative conditioning were evaluated. [Blood] Abstract

Pten Regulates Homeostasis and Inflammation-Induced Migration of Myelocytes in Zebrafish
The expression of hematopoietic marker genes was analyzed via whole mount in situ hybridization assay in ptena and ptenb double mutant zebrafish. The embryonic myelopoiesis was characterized by living imaging and whole mount in situ immunofluorescence with confocal microscopy, as well as cell-specific chemical staining for neutrophils and macrophages. [J Hematol Oncol] Full Article

Altered Hematopoietic Stem Cell and Osteoclast Precursor Frequency in Cathepsin K Null Mice
Researchers investigated whether genetic ablation of CatK altered the number of hematopoietic stem cells and osteoclast precursor cells using two mouse models: CatK-/- mice and a knock-in mouse model in which the CatK gene is replaced by cre recombinase. [J Cell Biochem] Abstract


Pre-Transplant Administration of Imatinib for Allogeneic Hematopoietic Stem Cell Transplantation in Patients with BCR-ABL-Positive Acute Lymphoblastic Leukemia
Investigators evaluated the impact of pre-transplant imatinib administration on the outcome of allogeneic hematopoietic stem cell transplantation in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia. [Blood] Abstract

Reduced Intensity Conditioning, Combined Transplantation of Haploidentical Hematopoietic Stem Cells and Mesenchymal Stem Cells in Patients with Severe Aplastic Anemia
Investigators examined if transplantation of combined haploidentical hematopoietic stem cells and mesenchymal stem cells affected graft failure and graft-versus-host disease in patients with severe aplastic anemia. [PLoS One] Full Article

Identification of Hematopoietic Progenitor Cell Donor Characteristics Predicting Successful Mobilization: Results of an Italian Multicenter Study
Prolonged stimulation and repeated collections or failure to reach hematopoietic progenitor cell (HPC) target may occur, increasing risks for donors and recipients. Researchers carried out a retrospective multicenter study on healthy donors, to identify donor variables which may correlate with HPC mobilization. [Transfusion] Abstract

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Contributions of the Host Microenvironment to Cancer-Induced Bone Disease
There is ever-increasing evidence for a multitude of ways in which the bone marrow microenvironment can promote disease pathogenesis, including via cancer-associated fibroblasts, the hematopoietic stem cell niche, myeloid-derived suppressor cells, and the sympathetic nervous system. This review discusses the recent advances in the understanding of the contribution of the host microenvironment to the development of cancer-induced bone disease. [Cancer Res] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

Attend ISCT 2014 in Paris, France!
Cynata Partners with University of Massachusetts to Conduct Graft versus Host Disease PoC Study
Cynata Therapeutics Ltd announced that it has commenced a study using its unique Cymerus™ stem cell technology to generate important data for partnering discussions and as a prelude to a proposed clinical trial in graft-versus-host disease. [Cynata Therapeutics Ltd] Press Release

R-Tech Ueno Announces Collaborative Research with Keio University for Treatment of Graft-versus-Host Disease (GvHD)
R-Tech Ueno announced the launch of a collaborative research on GvHD with Professor Kazuo Tsubota’s group, Department of Ophthalmology, Keio University School of Medicine. The aim of this collaborative research is to explore new methods for prevention and treatment of GvHD using a mouse model of GvHD. [R-Tech Ueno, Ltd.] Press Release

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CBER Finalizes Two Guidance Documents on Use of Hematopoietic Progenitor Cells
Two new guidance documents just released by the US Food and Drug Administration finalize recommendations for Biologics License Applications and Investigational New Drug Applications submitted in support of minimally manipulated placental or umbilical cord blood intended to help treat patients with hematopoietic system disorders. [Regulatory Affairs Professionals Society] Editorial

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Society for Developmental Biology 73rd Annual Meeting
July 17-21, 2014
Seattle, United States

NEW Fraunhofer Life Science Symposium: Medicinal Stem Cell Products
October 9-14, 2014
Leipzig, Germany

Visit our events page to see a complete list of events in the hematopoiesis research community.
NEW Postdoctoral Fellow – Mammalian Hematopoietic and Erythroid Development (The Icahn School of Medicine at Mount Sinai)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Postdoctoral Position – Human Stem Cell Biology and Hematopoiesis (Johns Hopkins University School of Medicine)

Postdoctoral Position – Stem Cell Biology (St. Jude Children’s Research Hospital)

Postdoctoral Position – Genes that Regulate Hematopoietic Stem Cells (University of Chicago)

Postdoctoral Fellow – Erythropoiesis and Iron Metabolism (University of Wisconsin – Madison)

Postdoctoral Position – Hematopoietic Stem Cell Biology (St. Jude Children’s Research Hospital)

Assistant Professorship – Hematopoietic Stem Cells and Microenvironment (University of Zurich)

Postdoctoral Position – Hematopoietic Stem Cell Physiology and Bone Marrow Failure (University of Michigan)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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