Volume 5.03 | Jan 28

Hematopoiesis News 5.03 January 28, 2014
Hematopoiesis News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Estrogen Promotes Blood-Forming Stem Cell Function
Scientists have known for years that stem cells in male and female sexual organs are regulated differently by their respective hormones. In a surprising discovery, researchers have found that stem cells in the blood-forming system – which is similar in both sexes – also are regulated differently by hormones, with estrogen proving to be an especially prolific promoter of stem cell self-renewal. [Press release from the Children’s Medical Center Research Institute at UT Southwestern discussing online prepublication in Nature] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
LABORATORY RESEARCH

High c-Kit Expression Identifies Hematopoietic Stem Cells with Impaired Self-Renewal and Megakaryocytic Bias
Investigators demonstrate that even the most rigorously defined hematopoietic stem cells (HSCs) can be separated into functionally distinct subsets based on c-Kit activity. Functional and transcriptome studies showed HSCs with low levels of surface c-Kit expression (c-Kitlo) and signaling exhibit enhanced self-renewal and long-term reconstitution potential compared with c-Kithi HSCs. [J Exp Med] Abstract

Clonal Expansion Capacity Defines Two Consecutive Developmental Stages of Long-Term Hematopoietic Stem Cells
By analyzing the cellular output after transplantation of stem cells differing in surface expression levels of the Kit receptor, scientists showed that long-term hematopoietic stem cells can be systematically subdivided into two subtypes with distinct reconstitution behavior. [J Exp Med] Abstract

Loss of p15Ink4b Accelerates Development of Myeloid Neoplasms in Nup98-HoxD13 Transgenic Mice
Researchers report that loss of p15Ink4b collaborates with Nup98-HoxD13 transgene in the development of predominantly myeloid neoplasms, namely acute myeloid leukemia, myeloproliferative disease and myelodysplastic syndromes. [Stem Cells] Abstract

Hematopoietic Stem/Progenitor Cells Express Myoglobin and Neuroglobin: Adaptation to Hypoxia or Prevention from Oxidative Stress?
Investigators provide for the first time novel functional and molecular evidences that human hematopoietic stem/progenitor cells express myoglobin at level comparable with that of a muscle-derived cell line. [Stem Cells] Abstract

Posttransplantation Bone Marrow Assessment by Quantifying Hematopoietic Cell-Derived mRNAs in Plasma Exosomes/Microvesicles
Researchers hypothesized that hematopoietic precursor cells might release exosomes and microvesicles (EMV) in bone marrow, and the resulting EMV would penetrate into peripheral blood. [Clin Chem] Abstract

Gene and miRNA Expression Profiles of Hematopoietic Progenitor Cells Vary Depending on Their Origin
Hematopoietic progenitors cells from G-CSF mobilized peripheral blood, bone marrow, or umbilical cord blood have different biological properties and different kinetic of engraftment post-transplantation, which might be at least in part explained by a different gene and miRNA expression pattern. In order to assess differences in gene and miRNA expression the authors analyzed whole genome expression profile as well as the expression of 384 miRNAs in CD34+ cells isolated from 18 healthy individuals. [Biol Blood Marrow Transplant] Abstract

Quantitative Phenotyping-Based In Vivo Chemical Screening in a Zebrafish Model of Leukemia Stem Cell Xenotransplantation
Scientists developed a novel phenotype-based in vivo screening method using leukemia stem cells xenotransplanted into zebrafish. Aldehyde dehydrogenase-positive cells were purified from chronic myelogenous leukemia K562 cells tagged with a fluorescent protein (Kusabira-orange) and then implanted in young zebrafish at 48 hours post-fertilization. [PLoS One] Full Article

Flt3 Signaling Regulates the Proliferation, Survival, and Maintenance of Multipotent Hematopoietic Progenitors that Generate B Cell Precursors
To further define the role of Flt3 signaling in lymphoid progenitor survival, mice deficient in Flt3 ligand that also expressed a Bcl2 transgene were generated. [Exp Hematol] Abstract

CLINICAL RESEARCH

HLA-Haploidentical T-Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation in Children with Fanconi Anemia
Researchers report the outcome of 12 consecutive pediatric patients with Fanconi anemia, who had neither an HLA-identical sibling nor an HLA-matched unrelated donor, and who were given T-cell depleted, CD34+ positively selected cells from an haploidentical related donor, after a reduced intensity, fludarabine-based conditioning regimen. [Biol Bone Marrow Transplant] Abstract

Health-Related Quality of Life of Patients with Newly Diagnosed Chronic Myeloid Leukemia Treated with Allogeneic Hematopoietic SCT versus Imatinib
To evaluate and compare the health-related quality of life of patients with newly diagnosed CML in the first chronic phase receiving HLA-identical sibling donor hematopoietic SCT or imatinib, a cross-sectional study that was part of a prospective cohort study at the Institute of Hematology, Peking University was performed. [Bone Marrow Transplant] Abstract

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REVIEWS
Conditioning Regimens in Allo-SCT for Thalassemia Major
This review addresses the reported clinical studies in patients with advanced thalassemia major and the authors summarized our suggested conditioning approach to improve the outcome after SCT. [Bone Marrow Transplant] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

Strategies to Inhibit GvHD while Sparing the Graft-versus-Tumor Response: Finding the Sweet Spot
 
INDUSTRY NEWS
BioLineRx Receives Orphan Drug Designation for Novel Stem Cell Mobilization Treatment
BioLineRx announced that it has received notice from the U.S. Food & Drug Administration confirming an Orphan Drug Designation of BL-8040 as a treatment for stem cell mobilization, in addition to the Orphan Drug Designation previously granted to BL-8040 as a treatment for acute myeloid leukemia. [BioLineRx]
Press Release

Minister Sherlock Opens Ireland’s First Human Use Stem Cell Manufacturing Facility at NUI Galway
The Centre for Cell Manufacturing Ireland at NUI Galway is the first ever facility on the island of Ireland to receive a license from the Irish Medicines Board to manufacture culture-expanded stem cells for human use. [National University of Ireland, Galway] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Challenges toward Sound Scientific Regulation of Cell Therapy Products
March 7-8, 2014
Kyoto, Japan

Visit our events page to see a complete list of events in the hematopoiesis research community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Fellow – Hematopoietic Stem Cell and Leukemia Research (City of Hope)

NEW Postdoctoral Position – Hematopoietic Stem Cell Physiology and Bone Marrow Failure (University of Michigan)

NEW Research Associate – Normal & Leukemic Stem Cells (King’s College London)

Postdoctoral Fellow – Morphogenetic Signaling Pathways in Development and Disease (University of Rochester Medical Center)

Scientific Affairs Coordinator (American Society of Hematology)

Postdoctoral Position – Erythroid and Myeloid Differentiation of Hematopoietic Stem Cells (Imagine Institute)

Postdoctoral Associate – Hematopoietic Differentiation (Northwestern University Feinberg School of Medicine)

Postdoctoral Fellow – Mammalian Hematopoietic and Erythroid Development (Mount Sinai Medical Center)


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