Volume 5.01 | Jan 14

Hematopoiesis News 5.01 January 14, 2014
Hematopoiesis News
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Musashi-2 Controls Cell Fate, Lineage Bias, and TGF-β Signaling in HSCs
Researchers report that conditional ablation of the RNA-binding protein Msi2 results in a failure of hematopoietic stem cell (HSC) maintenance and engraftment caused by a loss of quiescence and increased commitment divisions. [J Exp Med] Abstract
Take the "if" out of "diff": Reduce variability when differentiating to hematopoietic cells
PUBLICATIONS (Ranked by impact factor of the journal)

Bcl2 Overexpression Rescues the Hematopoietic Stem Cell Defects in Ku70-Deficient Mice by Restoration of Quiescence
Investigators found that HSC from Ku70-deficient mice are severely defective in self-renewal, competitive repopulation and BM hematopoietic niche occupancy, and loss of quiescence results in the dramatic defect in the maintenance of Ku70-deficient HSC. [Blood] Abstract

Selectins and Their Ligands Are Required for Homing and Engraftment of BCR-ABL1+ Leukemic Stem Cells in the Bone Marrow Niche
Researchers investigated adhesion pathways that contribute to engraftment of BCR-ABL1-induced chronic myelogenous leukemia-like myeloproliferative neoplasia in a mouse retroviral transduction/transplantation model. [Blood] Abstract

Hematopoietic Stem Cell Cytokines and Fibroblast Growth Factor-2 Stimulate Human Endothelial Cell-Pericyte Tube Co-Assembly in 3D Fibrin Matrices under Serum-Free Defined Conditions
Scientists describe a novel 3D fibrin matrix model using recombinant hematopoietic stem cell cytokines under serum-free defined conditions which promotes the assembly of human endothelial cell tubes with co-associated pericytes. [PLoS One] Full Article

Radiologic Differences between Bone Marrow Stromal and Hematopoietic Progenitor Cell Lines from Fanconi Anemia (Fancd2-/-) Mice
Researchers measured stress of hematopoiesis in long-term marrow cultures and radiosensitivity in clonogenic survival curves, as well as comet tail intensity, total antioxidant stores and radiation-induced gene expression in hematopoietic progenitor compared to bone marrow stromal cell lines. [Radiat Res] Abstract

Transcription Factor SCL/TAL1 Mediates the Phosphorylation of MEK/ERK Pathway in Umbilical Cord Blood CD34+ Stem Cells during Hematopoietic Differentiation
Investigators aimed to elucidate the effects of the epidermal growth factor receptor signal pathways underlying the biologic activity of stem cell leukemia (SCL)/T-cell acute lymphocytic leukemia 1 (TAL1) on normal hematopoietic development. [Blood Cells Mol Dis] Abstract


Identification of a Permissible HLA Mismatch in Hematopoietic Stem Cell Transplantation
Cohorts of 4,779 and 1,854 patients with hematologic malignancies receiving hematopoietic stem cell transplantation with unrelated donors matched in 8/8 and 7/8 HLA alleles were examined. [Blood] Abstract

Continuing Increased Risk of Oral/Esophageal Cancer after Allogeneic Hematopoietic Stem Cell Transplantation in Adults in Association with Chronic Graft-versus-Host Disease
The number of long-term survivors after hematopoietic stem cell transplantation (HSCT) showed steady increase in the past two decades. Second malignancies after HSCT are a devastating late complication. Investigators analyzed the incidence of, risk compared with that in the general population, and risk factors for secondary solid cancers. [Ann Oncol] Abstract

Visfatin Concentrations in Children with Leukemia before and after Stem Cell Transplantation
Visfatin (VF) is an adipocytokine, which performs many functions, including enhancing cell proliferation and biosynthesis of nicotinamide mono- and dinucleotides. It also seems to be involved in the development of glucose metabolism disturbances. Researchers aimed to determine of VF concentrations in children with leukemia, treated with stem cell transplantation. [Exp Hematol] Abstract

Technical Bulletin: Assays For Cord Blood
Advances in Understanding the Leukemia Microenvironment
Key components of the bone marrow microenvironment as a home for normal hematopoietic stem cells and the leukemia stem cell niches, and the molecular pathways critical for microenvironment/leukemia interactions via cytokines, chemokines and adhesion molecules as well as hypoxic conditions, are described in this review. [Br J Haematol] Abstract

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Biogen Idec and Sangamo Biosciences Announce Global Collaboration to Develop Treatments for Hemoglobinopathies
Biogen Idec and Sangamo BioSciences, Inc. announced an exclusive worldwide collaboration and license agreement focused on the development of therapeutics for hemoglobinopathies, inherited conditions that result from the abnormal structure or underproduction of hemoglobin. [Biogen Idec] Press Release

The Leukemia & Lymphoma Society Awards $12.6 Million in Research Grants
The Leukemia & Lymphoma Society (LLS) has awarded 21 new grants representing a total investment of $12.6 million to tackle six areas of high unmet medical need in the blood cancers. In response to requests for proposals from researchers in these six critical areas, LLS has awarded these grants under its Translational Research Program, an initiative designed to help accelerate the movement of promising discoveries from the lab to the clinic. [The Leukemia & Lymphoma Society] Press Release

Sunesis Pharmaceuticals Expands Hematology Franchise with Global Licenses to Two Kinase Inhibitor Programs
Sunesis Pharmaceuticals, Inc. announced that it has expanded its hematology franchise through separate global licensing agreements for two preclinical kinase inhibitor programs. [Sunesis Pharmaceuticals, Inc.]
Press Release

Independent Data Monitoring Committee Recommends Phase III Study of IMBRUVICA™ (Ibrutinib) versus Ofatumumab Be Stopped Early Based on Statistically Significant Improvement in Progression Free Survival and Overall Survival
Pharmacyclics, Inc. announced that an Independent Data Monitoring Committee unanimously recommended that the Phase III RESONATE study, PCYC-1112-CA, a head-to-head comparison of IMBRUVICATM (ibrutinib) versus ofatumumab, be stopped early because the primary and a key secondary endpoint of the study have been met. [Pharmacyclics, Inc.] Press Release

BioLineRx Announces Regulatory Submission for Novel Stem Cell Mobilization Treatment
BioLineRx announced that it has filed the necessary regulatory submissions to commence a Phase I trial for BL-8040, a novel treatment for the mobilization of stem cells from the bone marrow to the peripheral blood circulation. [BioLineRx] Press Release

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NEW Maximizing the Value of Imaging in Oncology Drug Development
March 12, 2014
London, United Kingdom

Visit our events page to see a complete list of events in the hematopoiesis research community.
NEW Scientific Affairs Coordinator (American Society of Hematology)

NEW Postdoctoral Position – Erythroid and Myeloid Differentiation of Hematopoietic Stem Cells (Imagine Institute)

Postdoctoral Associate – Hematopoietic Differentiation (Northwestern University Feinberg School of Medicine)

Postdoctoral Fellow – Mammalian Hematopoietic and Erythroid Development (Mount Sinai Medical Center)

Chief Medical Officer – Novel Therapeutics in Oncology and Autoimmune Disease (Immunomedics, Inc.)

Clinical MD – Clinical Development Program for Oncology and Autoimmune Diseases (Immunomedics, Inc.)

Postdoctoral Fellow – Molecular Basis of Clonal Evolution in Leukemia (Northwestern University)

Postdoctoral Position – Hematopoietic Stem Cell Research (Lund Stem Cell Center)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

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