Volume 4.47 | Dec 3

Hematopoiesis News 4.47 December 3, 2013
Hematopoiesis News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Oncogenic Nras Has Bimodal Effects on Stem Cells that Sustainably Increase Competitiveness
Scientists showed that a single allele of oncogenic NrasG12D increases hematopoietic stem cell proliferation but also increases reconstituting and self-renewal potential upon serial transplantation in irradiated mice, all prior to leukemia initiation. [Nature] Abstract | Press Release
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PUBLICATIONS (Ranked by impact factor of the journal)
LABORATORY RESEARCH

Gata2 cis-Element Is Required for Hematopoietic Stem Cell Generation in the Mammalian Embryo
Scientists describe a deletion of a Gata2 cis-element that depletes fetal liver hematopoietic stem cells, is lethal at E13-14 of embryogenesis, and is mutated in an immunodeficiency that progresses to myelodysplasia/leukemia. [J Exp Med] Abstract | Press Release

Aggf1 Acts at the Top of the Genetic Regulatory Hierarchy in Specification of Hemangioblasts in Zebrafish
Scientists showed that aggf1 acts at the top of the genetic regulatory hierarchy in the specification of hemangioblasts in zebrafish. Knockdown of aggf1 expression decreases expression of endothelial cell-specific markers (cdh5, admr), and disrupts primitive hematopoiesis as shown by a decreased number of erythroid cells and reduced expression of gata1 (marker for erythroid progenitors) and pu.1 (myeloid progenitors). [Blood] Abstract

CXCR7 Participates in CXCL12-Induced CD34+ Cell Cycling through β-Arrestin-Dependent Akt Activation
Blocking CXCR7 inhibited CXCL12-induced Akt activation as well as the percentage of CD34+ cells in cycle, colony formation and survival, demonstrating its participation in CXCL12-induced functional effects in hematopoietic stem/progenitor cells. [Blood] Abstract

Mitigation of Radiation Induced Hematopoietic Injury via Regulation of Cellular MAPK/Phosphatase Levels and Increasing Hematopoietic Stem Cells
Scientists describe a novel strategy for mitigation of ionizing radiation induced hematopoietic syndrome by suppressing the activity of MKP3 resulting in ERK activation and enhanced abundance of hematopoietic stem cells using an antioxidant flavonoid baicalein (5,6,7 trihydroxyflavone). [Free Radic Biol Med] Abstract

Hematopoietic Stem and Progenitor Cell Activation during Chronic Dermatitis Provoked by Constitutively Active Aryl-Hydrocarbon Receptor Driven by Keratin 14 Promoter
To clarify how the Keratin 14 promoter-driven aryl-hydrocarbon receptor (AhR) activation influences hematopoiesis, investigators analyzed bone marrow and spleen of constitutively active AhR mice. [Toxicol Sci] Abstract

Canonical Wnt Signaling Promotes Early Hematopoietic Progenitor Formation and Erythroid Specification during Embryonic Stem Cell Differentiation
Scientists investigated the effects of canonical Wnt/β-catenin signaling during early embryonic differentiation and hematopoietic specification using an embryonic stem cell system. [PLoS One] Full Article

Hematopoietic Stem and Progenitor Cells Acquire Distinct DNA-Hypermethylation during In Vitro Culture
Researchers compared DNA-methylation (DNAm) profiles of freshly isolated and culture-expanded hematopoietic stem and progenitor cells. Culture conditions of CD34+ cells – either with or without mesenchymal stromal cells – had relatively little impact on DNAm, although proliferation is greatly increased by stromal support. [Sci Rep] Full Article

CLINICAL RESEARCH

Autoimmune Hematological Diseases after Allogeneic Hematopoietic Stem Cell Transplantation in Children. An Italian Multi-Center Experience
Between 1998 and 2011, 1,574 consecutive children underwent allogeneic hematopoietic stem cell transplantation in nine Italian centers. Thirty-three children (2.1%) developed autoimmune hematological diseases: 15 autoimmune hemolytic anemia, 10 immune thrombocytopenia, five Evans’ syndrome, two pure red cell aplasia, and one immune neutropenia. [Biol Bone Marrow Transplant] Abstract

Influence of Two Different Doses of Antithymocyte Globulin in Patients with Standard-Risk Disease following Haploidentical Transplantation: A Randomized Trial
To evaluate the effect of the different doses of antithymocyte globulin on the incidence of acute GVHD among patients receiving hematopoietic SCT without ex vivo T-cell-depletion from haploidentical donors, 224 patients with standard-risk hematological malignancy were randomized in this study. [Bone Marrow Transplant] Abstract

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REVIEWS
Genetic Modification of Hematopoietic Stem Cells as a Therapy for HIV/AIDS
The authors suggest that although autologous, gene-modified hematopoietic stem cell-transplantation may significantly reduce plasma viremia, reaching the lower detection limits currently obtainable through daily HAART will remain a challenging endeavor that will require innovative combinatorial therapies. [Viruses] Abstract | Full Article

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.
 
INDUSTRY NEWS
bluebird bio Announces First Patient Transplanted in Phase I/II HGB-205 Study for the Treatment of Beta-Thalassemia and Sickle Cell Anemia
bluebird bio, Inc. announced that the first subject with beta-thalassemia major has been enrolled in its Phase I/II HGB-205 study in France and has undergone infusion with bluebird bio’s LentiGlobin drug product in an autologous hematopoietic stem cell transplantation. [Business Wire] Press Release

Polaris Group Files New IND for ADI-PEG 20 in Leukemia
Polaris Group announced that it has filed an Investigational New Drug Application (IND) application with the United States Food and Drug Administration to begin Phase I clinical trials to test ADI-PEG 20, arginine deiminase formulated with polyethylene glycol, for the treatment of acute myeloid leukemia. [PR Newswire Association LLC] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW BMT Tandem Meeting 2014
February 26-March 2, 2014
Grapevine, United States

Visit our events page to see a complete list of events in the hematopoiesis research community.
 
JOB OPPORTUNITIES
NEW Chief Medical Officer (Immunomedics, Inc.)

NEW Clinical MD – Clinical Development Program for Oncology and Autoimmune Diseases (Immunomedics, Inc.)

NEW Postdoctoral Fellow – Molecular Basis of Clonal Evolution in Leukemia (Northwestern University)

Postdoctoral Positions – Hematopoietic Stem Cell Physiology (University of Michigan)

PhD Student – Hematopoiesis and Immunopathology (Sanquin)

Postdoctoral Position – Hematopoietic Stem Cell Research (Lund Stem Cell Center)

Director of Sponsored Programs (Wake Forest Institute for Regenerative Medicine)

Adult Stem Cell Transplant Physician (John Theurer Cancer Center)

Postdoctoral Position – Hematopoietic Stem Cell Biology (St. Jude Children’s Research Hospital)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)


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