Volume 4.46 | Nov 26

Hematopoiesis News 4.46 November 26, 2013
Hematopoiesis News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Contractile Forces Sustain and Polarize Hematopoiesis from Stem and Progenitor Cells
Mass spectrometry-calibrated intracellular flow cytometry of human hematopoiesis reveals myosin-II-B to be a major isoform that is strongly polarized in hematopoietic stem cells and progenitors and thereby downregulated in differentiated cells via asymmetric division. [Cell Stem Cell]
Abstract | Graphical Abstract | Press Release
Take the "if" out of "diff": Reduce variability when differentiating to hematopoietic cells
 
PUBLICATIONS (Ranked by impact factor of the journal)
LABORATORY RESEARCH

Ligand-Independent FLT3 Activation Does Not Cooperate with MLL-AF4 to Immortalize/Transform Cord Blood CD34+ Cells
Investigators explored whether FLT3.TKD mutation or increased expression of FLT3.WT cooperates with MLL-AF4 to immortalize/transform cord blood-CD34+ hematopoietic stem/progenitor cells. [Leukemia] Abstract

Blood Stem Cell Fate Regulation by Delta-1 Mediated Rewiring of IL-6 Paracrine Signaling
Scientists demonstrated that although Delta-1 (DL1) activates STAT3 signaling similarly to the gp130-activating cytokine IL-6, it has opposite effects on myeloid cell production. Mechanistically, these different outcomes are attributable to a DL1-mediated reduction in membrane bound IL-6R expression, converting progenitor cells from being directly IL-6 responsive, to requiring both IL-6 and the soluble IL-6R for activation. [Blood] Abstract

Differences between Healthy Hematopoietic Progenitors and Leukemia Cells with Respect to CD44 Mediated Rolling versus Adherence Behavior on Hyaluronic Acid Coated Surfaces
Researchers quantitatively assessed the interaction of hematopoietic progenitor cells derived from umbilical cord blood, mobilized peripheral blood (mPB) and bone marrow (BM) from healthy donors, as well as primary leukemia blasts from PB and BM of patients with acute myeloid leukemia with hyaluronic acid. [Biomaterials] Abstract

Cell-Intrinsic In Vivo Requirement for the E47-p21 Pathway in Long-Term Hematopoietic Stem Cells
Scientists showed a direct genetic link between the transcription factor E47 and the major cell cycle regulator p21 in controlling long-term hematopoietic stem cell integrity in vivo under repopulation stress. [J Immunol] Abstract

Evaluation of Engraftment and Immunological Tolerance after Reduced Intensity Conditioning in a Rhesus Hematopoietic Stem Cell Gene Therapy Model
Scientists evaluated reduced intensity conditioning transplantation with 4Gy total body irradiation in two rhesus macaques that received equal parts of CD34+ cells transduced with green fluorescent protein-expressing lentiviral vector and empty vector not expressing transgenes. [Gene Ther] Abstract

Changes in the Frequencies of Human Hematopoietic Stem and Progenitor Cells with Age and Site
Investigators enumerated CD45hi/CD34+ and CD45hi/CD133+ human hematopoietic stem cells and granulocyte-monocyte colony forming progenitor cells in blood and trochanteric and femoral bone marrow in 233 individuals. Stem cell frequencies were determined by multi-parameter flow cytometry employing an internal control to determine the intrinsic variance of the assays. [Exp Hematol] Abstract

CLINICAL RESEARCH

Diverse T Cell Responses Characterize the Different Manifestations of Cutaneous Graft-versus-Host Disease
Graft-versus-host disease is a major complication of allogeneic hematopoietic stem cell transplantation (HCT) and can present in an acute (aGVHD), a chronic lichenoid (clGVHD) and a chronic sclerotic form (csGVHD). It is unclear whether similar or different pathomechanisms lead to these distinct clinical presentations. To address this issue, researchers collected lesional skin biopsies from aGVHD, clGVHD and csGVHD patients as well as serial non-lesional biopsies from HCT-recipients and subjected them to phenotypic and functional analyses. [Blood] Abstract

Analysis of Donor and Recipient ABO-Incompatibility and Antibody Associated Complications after Allogeneic Stem Cell Transplantation with Reduced Intensity Conditioning
A retrospective analysis of 310 patients that underwent allogeneic hematopoietic stem cell transplantation (ASCT) with reduced intensity condition between 1998 and 2011 was performed to investigate the frequency and clinical implications of anti-Red Blood Cell antibodies in passenger lymphocyte syndrome after minor ABO mismatch (mm), persistent or reoccurring recipient type ABO antibodies after major ABO mm ASCT and autoimmune hemolytic anemia. [Biol Blood Marrow Transplant] Abstract

Got Cells? Rare progenitor and immune cells ready for your research.
 
REVIEWS
The Evolving Art of Hematopoietic Stem Cell Transplantation: Translational Research in Post-Transplant Immune Reconstitution and Immunosuppression
Clinical advances in allogeneic hematopoietic stem cell transplantation have resulted in dramatically improved clinical outcomes over the past two decades, resulting in a significant expansion of transplant utilization to many recipients who would previously have been excluded from consideration, including elderly recipients and individuals lacking matched sibling or unrelated donors. [Immunol Res] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

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INDUSTRY NEWS
Gentium Receives EMA Orphan Drug Designation for Defibrotide for the Prevention of GvHD
Gentium SpA announced that the European Commission has granted Orphan Drug Designation to Defibrotide for the prevention of Graft versus Host Disease (GvHD). The designation follows a positive opinion released by the Committee for Orphan Medicinal Products of the European Medicines Agency (EMA). [Gentium SpA] Press Release

OmniBio Announces Notice of Allowance for New Use Patent
OmniBio Pharmaceutical, Inc. announced that it has received a Notice of Allowance from the Canadian Patent Office for the use of alpha-1 antitrypsin in reducing the risk of a non-organ transplant rejection, reducing the risk of developing graft versus host disease (GvHD) and for treating GvHD in patients who have received a cornea, bone marrow, stem cell or pancreatic islet cell transplant. [OmniBio Pharmaceutical, Inc.]
Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 19th Congress of the European Hematology Association (EHA)
June 12-15, 2014
Milan, Italy

Visit our events page to see a complete list of events in the hematopoiesis research community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Positions – Hematopoietic Stem Cell Physiology (University of Michigan)

PhD Student – Hematopoiesis and Immunopathology (Sanquin)

Postdoctoral Position – Hematopoietic Stem Cell Research (Lund Stem Cell Center)

Director of Sponsored Programs (Wake Forest Institute for Regenerative Medicine)

Adult Stem Cell Transplant Physician (John Theurer Cancer Center)

Postdoctoral Position – Hematopoietic Stem Cell Biology (St. Jude Children’s Research Hospital)

Postdoctoral Position – Human Pluripotent and Hematopoietic Stem Cell Bioinformatics (Albert Einstein College Medicine)

Translational Clinician-Scientist – Stem Cell Transplantation (Boston Children’s Hospital)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)


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