Volume 4.31 | Aug 13

Hematopoiesis News 4.31 August 13, 2013
Hematopoiesis News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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TOP STORY
ST2 as a Marker for Risk of Therapy-Resistant Graft-versus-Host Disease and Death
Researchers compared 12 biomarkers in plasma obtained a median of 16 days after therapy initiation from ten patients with a complete response by day 28 after therapy initiation and in plasma obtained from ten patients with progressive graft-versus-host disease during therapy. [N Engl J Med] Abstract | Press Release
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PUBLICATIONS (Ranked by impact factor of the journal)
LABORATORY RESEARCH

Platelet-Biased Stem Cells Reside at the Apex of the Hematopoietic Stem-Cell Hierarchy
Scientists identified and prospectively isolated a molecularly and functionally distinct mouse hematopoietic stem cell subset primed for platelet-specific gene expression, with enhanced propensity for short- and long-term reconstitution of platelets. [Nature] Abstract

BET Protein Inhibition Shows Efficacy against JAK2V617F Driven Neoplasms
Scientists report that I-BET151, a highly specific BET family bromodomain inhibitor, leads to growth inhibition in a human erythroleukemic cell line as well as in erythroid precursors isolated from polycythemia vera patients. One of the genes most highly down regulated by I-BET151 was LMO2, an important oncogenic regulator of hematopoietic stem cell development and erythropoiesis. [Leukemia] Abstract

Molecular Functions of the LIM-Homeobox Transcription Factor Lhx2 in Hematopoietic Progenitor Cells Derived from Mouse Embryonic Stem Cells
Researchers analyzed the functions of Lhx2 in that process using an embryonic stem (ES) cell line harboring an inducible Lhx2 gene cassette. When ES cells are cultured on OP9 stromal cells, hematopoietic progenitor cells (HPCs) are differentiated and these HPCs are prone to undergo rapid differentiation into mature hematopoietic cells. [Stem Cells] Abstract

Distinct Temporal Requirements for Runx1 in Hematopoietic Progenitors and Stem Cells
To define more precisely when Runx1 transitions from an essential factor to a homeostatic regulator of erythroid/myeloid progenitors and hematopoietic stem cells, and whether that transition requires fetal liver colonization, investigators performed conditional, timed deletions of Runx1 between E7.5 and E13.5. [Development] Abstract

Inflammation-Mediated Notch Signaling Skews Fanconi Anemia Hematopoietic Stem Cell Differentiation
Researchers report that deregulation of Notch signaling skews hematopoietic stem cell differentiation in mouse models of Fanconi anemia, a genetic disorder associated with bone marrow failure and progression to leukemia and other cancers. [J Immunol] Abstract

Placental Growth Factor Expression Is Required for Bone Marrow Endothelial Cell Support of Primitive Murine Hematopoietic Cells
Investigators demonstrated that endothelial cells derived from the bone marrow supported hematopoietic stem/progenitor cells to a higher degree than other endothelial or stromal cell populations. [PLoS One]
Full Article

CLINICAL RESEARCH

Second Allograft for Hematologic Relapse of Acute Leukemia after First Allogeneic Stem-Cell Transplantation from Related and Unrelated Donors: The Role of Donor Change
Researchers performed a retrospective registry study on 179 second allogeneic hematopoietic stem-cell transplantations (HSCT2s) given for relapse after first hematopoietic stem-cell transplantation from matched related donors or unrelated donors, using identical or alternative donors for HSCT2. [J Clin Oncol] Abstract

Autologous Hematopoietic Stem Cell Transplantation Following High Dose Chemotherapy for Non-Rhabdomyosarcoma Soft Tissue Sarcomas
The authors assessed the effectiveness and safety of high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation for all stages of non-rhabdomyosarcoma soft tissue sarcomas in children and adults. [Cochrane Database Syst Rev] Abstract

Genetic Susceptibility to Anthracycline-Related Congestive Heart Failure in Survivors of Hematopoietic Cell Transplantation
Investigators examined the association between the development of congestive heart failure after hematopoietic cell transplantation and polymorphisms in 16 candidate genes involved in anthracycline metabolism, iron homeostasis, anti-oxidant defense, and myocardial remodeling. [Br J Haematol] Abstract

Take the 'if' out of 'diff': Reduce variability when differentiating to hematopoietic cells
 
REVIEWS
JAK of All Trades: JAK2-STAT5 as Novel Therapeutic Targets in BCR-ABL1+ Chronic Myeloid Leukemia
The authors present recent evidence showing that chronic myeloid leukemia stem cells do not depend on BCR-ABL1 kinase activity but require the continuous support of the hematopoietic niche and its distinct cytokine environment; and suggest that it has the potential to resolve the dispute. [Blood] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.
 
SCIENCE NEWS
Karyopharm Therapeutics Announces Preclinical Data for Selinexor (KPT-330) in Acute Myeloblastic Leukemia (AML) and Acute Lymphoblastic Leukemia (ALL) Models at FASEB Science Research Conferences
Karyopharm Therapeutics Inc. announced that a poster titled “Novel inhibitors of CRM1/XPO1 nuclear exporter exhibit [striking] anti-leukemic activity against AML and T-ALL cells while sparing normal hematopoietic cells” was presented. The poster provided preclinical data showing evidence that Karyopharm’s proprietary SINE Exportin 1 (XPO1 or CRM1) antagonists induce apoptosis of leukemic cells in models of AML and ALL. [Press release from Karyopharm Therapeutics Inc. discussing research presented at the Federation of American Societies for Experimental Biology (FASEB) 2013 Conferences on Hematological Malignancies, Saxtons River] Press Release

Stem Cell Society Singapore 2013 Symposium
 
INDUSTRY NEWS
Celator® Pharmaceuticals Announces Start of Clinical Study in Patients with Untreated Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia at High Risk of Treatment-Related Mortality
Celator Pharmaceuticals, Inc. announced that patients have been enrolled in an investigator-initiated clinical study evaluating CPX-351 (cytarabine:daunorubicin) Liposome Injection in patients with untreated high-risk MDS or acute myeloid leukemia, excluding acute promyelocytic leukemia, at high risk of treatment-related mortality. [Celator Pharmaceuticals, Inc.] Press Release

Kite Pharma Appoints Leading Cancer Immunotherapy Experts to Its Scientific Advisory Board
Kite Pharma Inc. announced the appointment of three leading experts in the areas of immunotherapy, chimeric antigen receptor technology, and gene therapy to its Scientific Advisory Board. [PR Newswire Association LLC] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 8th National Cancer Research Institute (NCRI) Conference
November 3-6, 2013
Liverpool, United Kingdom

Visit our events page to see a complete list of events in the hematopoiesis research community.
 
JOB OPPORTUNITIES
NEW Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

NEW Research Associate – Stem Cell and Leukemia Epigenetics (King’s College London)

Postdoctoral Position – Hematopoietic Stem Cells (St. Jude Children’s Research Hospital)

Postdoctoral Position – Hematopoiesis (Lund Stem Cell Center)

Postdoctoral Research Associates – Stem Cell Biology (University of Illinois at Chicago)

Postdoctoral Fellow – Human Stem Cell Biology and Hematopoiesis (Johns Hopkins University School of Medicine)

Tenure-Track Position – Cell Biologist (McGill University)

Postdoctoral Appointee – Cell Cycle Regulation in Tumor Stem Cells (Rutgers University, Rutgers Cancer Institute of New Jersey)

Postdoctoral Position – Stem Cell Biology (St. Jude Children’s Research Hospital)

Postdoctoral Fellow – Cancer Stem Cell Biology (McGill University)

Research Associate (Assistant Professor) – Pediatric Hematology/Oncology (The University of Chicago)

Director of Cell Processing Facility (S L Collins Associates, Inc.)

Postdoctoral Researcher – Hematopoietic Stem Cells (Albert Einstein College of Medicine)


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