Volume 4.17 | May 7

Hematopoiesis News 4.17 May 7, 2013
Hematopoiesis News
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TOP STORY
Scientists Assemble Genetic Playbook for Acute Leukemia
A team of researchers has identified virtually all of the major mutations that drive acute myeloid leukemia (AML), a fast-growing blood cancer in adults that often is difficult to treat. The findings pave the way for developing better treatments for AML based on the genetic profile of a patient’s cancer. They also could lead to ways to more accurately predict the severity of disease in individual patients. [Press release from Washington University School of Medicine in St. Louis discussing online prepublication in The New England Journal of Medicine] Press Release | Abstract

Free Nature Reviews Immunology Poster: The Immune Response to HIV
PUBLICATIONS (Ranked by impact factor of the journal)

LABORATORY RESEARCH

Mesp1 Patterns Mesoderm into Cardiac, Hematopoietic, or Skeletal Myogenic Progenitors in a Context-Dependent Manner
To define the early embryonic cell population that responds to Mesp1, researchers performed pulse inductions of gene expression over tight temporal windows following embryonic stem cell differentiation. Remarkably, instead of promoting cardiac differentiation in the initial wave of mesoderm, Mesp1 binds to the Tal1 +40 kb enhancer and generates Flk-1+ precursors expressing Etv2 and Tal1 that undergo hematopoietic differentiation. [Cell Stem Cell] Abstract | Graphical Abstract

Chemotherapy-Induced Bone Marrow Nerve Injury Impairs Hematopoietic Regeneration
Researchers demonstrated that chemotherapy-induced nerve injury in the bone marrow of mice is a crucial lesion impairing hematopoietic regeneration. [Nat Med] Abstract | Press Release

AML1-ETO Mediates Hematopoietic Self-Renewal and Leukemogenesis through a COX/β-Catenin Signaling Pathway
The data indicate an important role of a cyclooxygenase (COX)/β-catenin-dependent signaling pathway in tumor initiation, growth and self-renewal, and provide the rationale for testing potential benefits from common COX inhibitors as a part of acute myelogenous leukemia (AML) treatments. [Blood] Abstract

Mast Cell-Deficient KitW-sh “Sash” Mutant Mice Display Aberrant Myelopoiesis Leading to the Accumulation of Splenocytes That Act as Myeloid-Derived Suppressor Cells
Mast cell-deficient KitW-sh “sash” mice are widely used to investigate mast cell functions. However, mutations of c-Kit also affect additional cells of hematopoietic and nonimmune origin. Researchers demonstrated that KitW-sh causes aberrant extramedullary myelopoiesis characterized by the expansion of immature lineage-negative cells, common myeloid progenitors, and granulocyte/macrophage progenitors in the spleen. [J Immunol] Abstract

Ddx46 Is Required for Multi-Lineage Differentiation of Hematopoietic Stem Cells in Zebrafish
Results provide the first genetic evidence that zebrafish Ddx46 is required for the multi-lineage differentiation of hematopoietic stem cells during development, through the regulation of specific gene expressions. [Stem Cells Dev] Abstract

In Vivo Tracking and Comparison of the Therapeutic Effects of MSCs and HSCs for Liver Injury
Mesenchymal stem cells (MSCs), hematopoietic stem cells (HSCs) and the combination of both cells were obtained from the bone marrow of male mice expressing enhanced green fluorescent protein and injected into the female mice with or without liver fibrosis. The distribution of the stem cells, survival rates, liver function, hepatocyte regeneration, growth factors and cytokines of the recipient mice were analyzed. [PLoS One] Full Article

Quantification and Localization of Erythropoietin-Receptor-Expressing Cells in the Liver of Xenopus laevis
Researchers aimed to determine the dynamics of erythropoiesis in the livers of normal and anemic X. laevis by identifying the number and precise location of mature and immature erythrocytes. [Cell Tissue Res] Abstract

CLINICAL RESEARCH

Serum 2-Hydroxyglutarate Levels Predict Isocitrate Dehydrogenase Mutations and Clinical Outcome in Acute Myeloid Leukemia
Scientists studied whether 2-hydroxyglutarate (2HG) measurements in AML patients correlate with IDH mutations, and whether diagnostic or remission 2HG measurements predict survival. [Blood] Abstract

Outcomes of Adults with Acute Lymphoblastic Leukemia (ALL) following Relapse Post Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)
Researchers retrospectively analyzed outcomes of 123 adult patients with ALL who relapsed after a first HSCT. [Biol Blood Marrow Transplant] Abstract

The Kinetics and Apoptotic Profile of Circulating Endothelial Cells in Autologous Hematopoietic Stem Cell Transplantation in Patients with Lymphoproliferative Disorders
In neoplastic disorders, endothelial cells take part in tumor progression and also influence the recovery of hematopoiesis after high-dose chemotherapy. Measurements of circulating endothelial cells, their subsets and kinetics were taken in patients with lymphoid malignancies during autologous hematopoietic stem cell transplantation. [Ann Hematol] Abstract

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REVIEWS

Implications of DPP4 Modification of Proteins that Regulate Stem/Progenitor and More Mature Cell Types
This review addresses the potential implications of modifying effects of Dipeptidylpeptidase (DPP) 4 on a large number of cytokines and other growth regulating factors with either proven or putative DPP4 truncation sites on hematopoietic cells, and subsequent effects of DPP4-truncated proteins on multiple aspects of steady state and stressed hematopoiesis including stem/progenitor cell, and more mature cell, function. [Blood] Abstract

Regulation of Stem Cell Therapies Under Attack in Europe: For Whom the Bell Tolls
In this commentary, the authors discuss why only rigorous science and rigorous regulation can ensure translation of science into effective therapies rather than into ineffective market products, and mark, at the same time, the sharp distinction between the striving for new therapies and the deceit of patients. [EMBO J] Full Article | Press Release

Visit our reviews page to see a complete list of reviews in the hematopoietic research field.

11th Annual International Cord Blood Symposium | San Francisco

INDUSTRY NEWS

Foundation Medicine and Memorial Sloan-Kettering Cancer Center Announce Partnership to Advance Patient Care in Hematologic Cancers
Foundation Medicine and Memorial Sloan-Kettering Cancer Center announced a partnership that brings together clinical, genomic and computational expertise to advance patient care in hematologic cancers. This effort will focus on co-development of a new Foundation Medicine molecular diagnostic product designed to match patients with hematologic cancers (leukemia, lymphoma or myeloma) with the most rational targeted therapies or clinical trials for their cancer. [Memorial Sloan-Kettering Cancer Center] Press Release

Pluristem Develops PLX-RAD Cells for Use in Hematology: Enhancing Hematopoietic Stem Cell Engraftment Will Be the First Indication 
Pluristem Therapeutics Inc. announced that it has identified its first clinical indication in the hematology field for its Placental eXpanded (PLX) RAD cells for the enhancement of the engraftment of hematopoietic stem cells in patients experiencing a delay or failure of their bone marrow transplant. [Pluristem Therapeutics Inc.] Press Release

ViaCord® to Advance Cord Blood Stem Cell Therapy Research through Collaboration with the Center for International Blood and Marrow Transplant Research®
ViaCord, PerkinElmer’s family cord blood and tissue preservation business, is collaborating with the Center for International Blood and Marrow Transplant Research to collect, maintain and publish research from ViaCord’s cord blood stem cell transplants. This collaboration will expand knowledge of cord blood-derived stem cell applications throughout the medical and research community. [PerkinElmer Inc.] Press Release

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POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW International Society for Stem Cell Research (ISSCR): Stem Cells in Translation
September 15-18, 2013
Florence, Italy

NEW International Society for Stem Cell Research (ISSCR): Stem Cells in Science & Medicine
October 14-17, 2013
Suzhou, China

NEW SELECTBIO CellTech 2014
January 28-29, 2014
San Diego, United States

Visit our events page to see a complete list of events in the hematopoietic community.

JOB OPPORTUNITIES
NEW Postdoctoral Fellow (Johns Hopkins University School of Medicine)

Postdoctoral Position (Inselspital Bern, University Hospital Bern)

Postdoctoral Fellow – Myeloproliferative Neoplasms (Mount Sinai Medical Center)

Postdoctoral Positions – Stem Cell Biology and Aging (Children’s Hospital Oakland Research Institute)

Cord Blood Laboratory Manager (Puget Sound Blood Center)

Postdoctoral Positions (Cancer Science Institute of Singapore)

Postdoctoral Scholarship – Leukemia Stem Cell Biology (Lund University – Faculty of Medicine)

Studentship – Novel Mechanisms in Blood Cancers Drug-Resistance (University of East Anglia)


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