Protein Is Vital to Successful ‘Homing’ of Stem Cells, Researchers Discover Researchers have discovered that a protein called Klf5 is required for successful “homing” of stem cells in the bone marrow during stem cell transplantation. Stem cells lacking Klf5, the researchers found, failed to engraft after transplantation, thereby reducing the efficiency of bone marrow transplants. [Press release from the University of Cincinnati discussing online prepublication in Nature Communications] Press Release | Abstract
Diverse and Heritable Lineage Imprinting of Early Hematopoietic Progenitors Researchers used a new quantitative version of ‘cellular barcoding’ to trace the in vivo fate of hundreds of lymphoid-primed multipotent progenitors (LMPPs) and hematopoietic stem cells at the single-cell level. These data demonstrate that LMPPs are highly heterogeneous in the cell types that they produce, separating into combinations of lymphoid-, myeloid- and dendritic-cell-biased producers. [Nature] Abstract
CD41 Expression Marks Myeloid Biased Adult Hematopoietic Stem Cells and Increases with Age The authors showed that platelet integrin CD41, currently thought to only transiently mark fetal hematopoietic stem cells (HSCs), is expressed on an adult HSC subtype that accumulates with age. CD41+ HSCs were largely quiescent and exhibited myeloerythroid and megakaryocyte gene priming, governed by Gata1, whereas CD41- HSCs were more proliferative and exhibited lymphoid gene priming. [Blood] Abstract
An Evolutionary Perspective on Chronic Myelomonocytic Leukemia Chronic myelomonocytic leukemia shares with other myeloid diseases a number of somatic gene mutations. These mutations can now be integrated within the framework of evolution theory to address the mechanisms of the disease. This review discusses the various models of disease emergence and progression and how this recent knowledge could drive rational therapeutic strategies. [Leukemia] Abstract
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Immunotherapy Showed Promising Antileukemia Activity in Pediatric Patients Researchers using patients’ own immune cells in an immunotherapy approach called “anti-CD19 chimeric antigen receptor T-cell therapy,” achieved responses in children whose acute lymphocytic leukemia had returned after a bone marrow transplant, according to preliminary results. [Press release from the American Association for Cancer Research (AACR) discussing research presented at the AACR Annual Meeting 2013, Washington] Press Release