Volume 4.07 | Feb 26

LABORATORY RESEARCH

CXCL12 in Early Mesenchymal Progenitors Is Required for Hematopoietic Stem-Cell Maintenance
Scientists selectively deleted Cxcl12 from candidate niche stromal cell populations and characterized the effect on hematopoietic progenitor cells. Deletion of Cxcl12 from mineralizing osteoblasts has no effect on hematopoietic stem cells or lymphoid progenitors. [Nature] Abstract | Press Release

Xist RNA Is a Potent Suppressor of Hematologic Cancer in Mice
Researched deleted Xist in the blood compartment of mice and demonstrate that mutant females develop a highly aggressive myeloproliferative neoplasm and myelodysplastic syndrome with 100% penetrance. Significant disease components include primary myelofibrosis, leukemia, histiocytic sarcoma, and vasculitis. Xist-deficient hematopoietic stem cells show aberrant maturation and age-dependent loss. [Cell]
Abstract | Graphical Abstract

Attenuation of AML1-ETO Cellular Dysregulation Correlates with Increased Leukemogenic Potential
Scientists investigated the role of two AML1-ETO C-terminal-interacting proteins, N-CoR, a transcriptional co-repressor, and SON, a splicing/transcription factor required for cell cycle progression, in AML1-ETO-induced leukemia development. [Blood] Abstract

DNA Damage in Stem Cells Activates p21, Inhibits p53, and Induces Symmetric Self-Renewing Divisions
Researchers showed that irradiation of hematopoietic and mammary stem cells up-regulates the cell cycle inhibitor p21, a known target of p53, which prevents p53 activation and inhibits p53 basal activity, impeding apoptosis and leading to cell cycle entry and symmetric self-renewing divisions. [Proc Natl Acad Sci USA] Abstract

The Novel Arsenical Darinaparsin Circumvents BRG1-Dependant, HO-1-Mediated Cytoprotection in Leukemic Cells
Scientists observed that, unlike arsenic trioxide (ATO), darinaparsin does not induce HO-1, even though it induces expression of other nuclear factor (erythroid-derived 2)-like 2-dependant detoxifying enzymes to a greater extent than ATO, in both cancer cell lines and patient-derived leukemic cells. [Leukemia] Abstract

Hematopoietic Protein-1 Regulates the Actin Membrane Skeleton and Membrane Stability in Murine Erythrocytes
The authors utilized mice lacking Hematopoietic Protein-1 (Hem-1) expression due to a non-coding point mutation in the Hem1 gene to show that absence of Hem-1 results in microcytic, hypochromic anemia characterized by abnormally shaped erythrocytes with aberrant F-actin foci and decreased lifespan. [PLoS One] Full Article

CLINICAL RESEARCH

T-Cell-Replete HLA-Haploidentical Hematopoietic Transplantation for Hematologic Malignancies Using Post-Transplantation Cyclophosphamide Results in Outcomes Equivalent to Those of Contemporaneous HLA-Matched Related and Unrelated Donor Transplantation
Outcomes of 271 consecutive patients undergoing T-cell-replete first allogeneic hematopoietic cell transplantation for hematologic malignancies performed contemporaneously at a single center were compared. Overall and disease-free survival were adjusted for effects of significant patient-, disease-, and transplantation-related covariates using a stratified Cox model. [J Clin Oncol] Abstract

Phase II Clinical Trial of Rapamycin-Resistant Donor CD4+ Th2/Th1 (T-Rapa) Cells after Low-Intensity Allogeneic Hematopoietic Cell Transplantation
Researchers performed a Phase II multi-center clinical trial of rapamycin-resistant donor CD4⁺ Th2/Th1 cells after allogeneic matched-sibling donor hematopoietic cell transplantation for therapy of refractory hematologic malignancy. [Blood] Abstract

Phase II Study of Arsenic Trioxide Followed by Autologous Hematopoietic Cell Transplantation for Relapsed Acute Promyelocytic Leukemia
The authors conducted a Phase II study to evaluate the efficacy and feasibility of a sequential treatment consisting of induction and consolidation with arsenic trioxide, peripheral blood stem cell harvest after high-dose cytarabine chemotherapy, and autologous hematopoietic cell transplantation. [Blood] Abstract

Pluristem Receives FDA Orphan Drug Status Designation for Treatment of Aplastic Anemia
Pluristem Therapeutics Inc. announced that the U.S. Food and Drug Administration (FDA) has designated Pluristem’s placental expanded cells orphan drug status for the treatment of aplastic anemia. [Pluristem Therapeutics Inc.] Press Release

Gentium Provides Update on the Review of Defibrotide Marketing Authorization
Gentium S.p.A. announced that the Company had presented an oral explanation at the European Medicines Agency’s Committee for Medicinal Products for Human Use as part of its Marketing Authorization Application for Defibrotide to treat and prevent hepatic veno-occlusive disease in adults and children undergoing hematopoietic stem cell transplantation therapy. [Gentium S.p.A.] Press Release

Expanding Public Access to the Results of Federally Funded Research
In a policy memorandum, Office of Science and Technology Policy Director John Holdren has directed Federal agencies with more than $100 million in R&D expenditures to develop plans to make the published results of federally funded research freely available to the public within one year of publication and requiring researchers to better account for and manage the digital data resulting from federally funded scientific research. [Office of Science and Technology Policy, The White House, United States] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW SMi’s Cell Culture 2013
July 3-4, 2013
London, United Kingdom

Visit our events page to see a complete list of events in the hematopoietic community.

Postdoctoral Position – Gene Regulation in the Hematopoietic and Immune Systems (Lund University)

Postdoctoral Position – Hematopoietic and Malignant Stem Cells (Istanbul University)

Postdoctoral Position – Stem Cell Biology (Washington University of Medicine)

Postdoctoral Research Associate – Stem Cell Biology and Epigenetics (University of Wisconsin)

Postdoctoral Position – Myeloproliferative Neoplasms (Mount Sinai Medical Center)

Postdoctoral Position – Stem Cell Research (University of Washington)

PhD Studentship (University Medical Center Groningen)

PhD Studentship – Hematopoietic Development and Bioinformatics (Karolinska Institute, Department of Laboratory Medicine)

Postdoctoral Position – Hematopoietic Stem Cells and Stem Cell Aging (Cincinnati Children’s Hospital Research Foundation)

Lecturer or Reader – Associate Professor (University of Reading)


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