Volume 4.04 | Feb 5

Hematopoiesis News 4.04 February 5, 2013
Hematopoiesis News

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Epidermal Growth Factor Regulates Hematopoietic Regeneration after Radiation Injury
Scientists identified epidermal growth factor to be highly enriched in the bone marrow serum of mice bearing deletion of Bak and Bax in TIE2-expressing cells in Tie2Cre; Bak1−/−; Baxflox/– mice. These mice showed radioprotection of the hematopoietic stem cell pool and 100% survival after a lethal dose of total-body irradiation. [Nat Med] Abstract | Press Release

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PUBLICATIONS (Ranked by impact factor of the journal)


RUNX1a Enhances Hematopoietic Lineage Commitment from Human Embryonic Stem Cells and Inducible Pluripotent Stem Cells
Researchers demonstrated that expression of endogenous RUNX1a, an isoform of RUNX1, parallels with lineage commitment and hematopoietic emergence from human pluripotent stem cells, including both human embryonic stem cells and inducible pluripotent stem cells. [Blood] Abstract

The Histone Demethylase UTX Regulates Stem Cell Migration and Hematopoiesis
Based on an shRNA library and SDF-1 migration screening assay, investigators identified the histone 3 lysine 27 demethylase UTX as a novel regulator for hematopoietic cell migration. Using hematopoietic stem and progenitor cells from their conditional UTX knockout mice, they were able to confirm the regulatory function of UTX on cell migration. [Blood] Abstract

Lmo2 Induces Hematopoietic Stem Cell Like Features in T-Cell Progenitor Cells Prior to Leukemia
Researchers analyzed proliferation, differentiation, and cell death in CD2-LIM domain Only 2 (Lmo2) transgenic thymic progenitor cells to understand the cellular effects of enforced Lmo2 expression. Lmo2 transgenic T-cell progenitor cells were blocked in differentiation, quiescent, and immortalized in vitro on OP9-DL1 stromal cells. [Stem Cells] Abstract

Synergistic Activity of Bortezomib and HDACis in Preclinical Models of B-Cell Precursor Acute Lymphoblastic Leukemia via Modulation of p53, PI3K/AKT and NF-κB
Anti-proliferative and pro-apoptotic effects of combined histone deacetylase inhibitor (HDACi)/proteasome inhibitor treatments were analyzed using B-cell precursor acute lymphoblastic leukemia (ALL) monocultures, cocultures with primary mesenchymal stroma cells from ALL-patients and xenograft mouse models. [Clin Cancer Res] Abstract

Hierarchical Organization of Osteoblasts Reveals the Significant Role of CD166 in Hematopoietic Stem Cell Maintenance and Function
Scientists previously demonstrated that osteoblasts (OB) maturational status influences hematopoietic stem cells function whereby immature OB with high Runx2 expression promote hematopoietic expansion. Here, they showed that CD166 expression on OB is directly correlated with Runx2 expression and high hematopoiesis enhancing activity. [Bone] Abstract

Abnormal Hematopoietic Phenotypes in Pim Kinase Triple Knockout Mice: Pim Kinase Regulates Hematopoiesis
Pim1-/-2-/-3-/- triple knockout (TKO) mice were used to determine the role of Pim kinases in hematopoiesis. Peripheral blood hematological parameters were measured in Pim TKO mice and age-matched wild-type controls. [J Hematol Oncol] Abstract | Full Article


Who Is the Better Donor for Older Hematopoietic Transplant Recipients: An Older-Aged Sibling or a Young, Matched Unrelated Volunteer?
Transplants in leukemia/lymphoma patients aged ≥50 years were analyzed comparing outcomes for recipients of HLA-matched siblings ≥50 versus HLA-matched unrelated donor < 50 years. [Blood] Abstract

Impact of a Donor Source on Adult Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia: A Retrospective Analysis from the Adult Acute Lymphoblastic Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation
Researchers retrospectively analyzed data of 1726 patients who underwent myeloablative allogeneic stem cell transplantation (allo-SCT) for adult Philadelphia chromosome-negative acute lymphoblastic leukemia. The sources of the allo-SCT were related donors, unrelated donors, and cord blood. [Ann Oncol] Abstract

Outcome after First Relapse in Adult Patients with Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia
To analyze the outcome of adult patients who developed a first relapse of acute lymphoblastic leukemia (ALL), the authors collected the clinical data of 332 patients with Philadelphia-chromosome negative ALL, aged 16-65 years, who relapsed after first complete remission (CR1) between 1998 and 2008 in 69 institutions all over Japan, including 58 patients who relapsed after allogeneic hematopoietic stem cell transplantation in CR1. [Br J Haemotol] Abstract

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The Evolving Role of Plerixafor in Hematopoietic Progenitor Cell Mobilization
The authors review the role of plerixafor in autologous and allogeneic transplantation as well as its emerging role in the treatment of acute leukemias. Emphasis is placed on the choice of appropriate patients for plerixafor use to assure an adequate stem cell yield while maximizing the cost effectiveness of using plerixafor. [Transfusion] Abstract

Arteriocyte Receives FDA Approval to Initiate Cellular Therapy Trial for Treatment of Thermal Burn Wounds in Wounded Warriors
Arteriocyte announced approval from the Food and Drug Administration (FDA) to initiate a Phase I clinical trial using its Magellan® System technology in the treatment of thermal burn wounds. The FDA Investigational Device Exemption allows Arteriocyte and its clinical partners to initiate evaluation of autologous platelet gel as an adjunctive therapy for autologous skin grafting in patients with thermal injuries. [PR Newswire Association LLC] Press Release

The Leukemia & Lymphoma Society Awards $1.68 Million to Improve Outcomes for Patients with Acute Promyelocytic Leukemia
The Leukemia & Lymphoma Society (LLS) has awarded Anand Jillella M.D., Chief of Hematology, Oncology and Bone Marrow Transplant at the Georgia Regents University in with $1.68 million in funding from LLS’s Therapy Acceleration Program. [Leukemia and Lymphoma Society] Press Release

1 Millionth Blood Stem Cell Transplant Marks Major Medical Milestone
The collaborative work of medical scientists and physicians across the globe has resulted in a major medical milestone: the world’s 1 millionth blood stem cell transplant. The Worldwide Network for Blood and Marrow Transplantation said the 1 millionth transplant occurred in late December 2012. [Worldwide Network for Blood and Marrow Transplantation] Press Release


National Institutes of Health (United States)

Food and Drug Administration (United States)
Center for Biologics Evaluation and Research (United States)
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)


NEW South Central Association of Blood Banks 2013 Annual Meeting: Blood Banking on the Bayou – You Gotta Geaux!
April 18-21, 2013
Baton Rouge, United States

NEW 2013 Society for Hematology and Stem Cells (ISEH) Annual Scientific Meeting
August 22-25, 2013
Vienna, Austria

Visit our events page to see a complete list of events in the hematopoietic community.


Postdoctoral Position – Gene Regulation in the Hematopoietic and Immune Systems (Lund University)

Postdoctoral Positions – Stem Cell Biology (Children’s Hospital Oakland Research Institute)

Postdoctoral Position – Hematopoietic and Malignant Stem Cells (Istanbul University)

Postdoctoral Position – Stem Cell Biology (Washington University of Medicine)

Postdoctoral Research Associate – Stem Cell Biology and Epigenetics (University of Wisconsin)

Postdoctoral Position – Gene Expression and Regulation of Stem Cells (University of Texas at Houston)

Postdoctoral Position – Myeloproliferative Neoplasms (Mount Sinai Medical Center)

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