Volume 3.47 | Nov 27

Hematopoiesis News 3.47 November 27, 2012
Hematopoiesis News

     In this issue: Publications | ReviewsIndustry News | Policy News | Events | Jobs
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TOP STORY
C/EBPγ Deregulation Results in Differentiation Arrest in Acute Myeloid Leukemia
Researchers found that C/EBPγ mediates the myeloid differentiation arrest induced by C/EBPα deficiency and that targeting the C/EBPα-C/EBPγ axis rescues neutrophilic differentiation in a unique subset of acute myeloid leukemias. [J Clin Invest] Full Article

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PUBLICATIONS (Ranked by impact factor of the journal)

LABORATORY RESEARCH

miR-155 Targets Histone Deacetylase 4 (HDAC4) and Impairs Transcriptional Activity of B-Cell Lymphoma 6 (BCL6) in the Eµ-miR-155 Transgenic Mouse Model
Researchers provide a mechanistic insight into microRNA (miR)-155-induced leukemogenesis in an ectopic expression of miR-155 mouse model (Eμ-miR-155) through genome-wide transcriptome analysis of naïve B cells and target studies. [Proc Natl Acad Sci USA] Abstract

Prostaglandin E2 Increases Hematopoietic Stem Cell Survival and Accelerates Hematopoietic Recovery after Radiation Injury
Scientists demonstrated that prostaglandin E2 treatment in naïve mice inhibits apoptosis of hematopoietic stem and progenitor cells without changing their proliferation rate. [Stem Cells] Abstract

TiF1-Gamma Plays an Essential Role in Murine Hematopoiesis and Regulates Transcriptional Elongation of Erythroid Genes
Previous studies in zebrafish have identified an essential role for the transcriptional intermediary factor TIF1γ in erythropoiesis by regulating the transcription elongation of erythroid genes. To study if TIF1γ plays a similar role in murine erythropoiesis and to assess its function in other blood lineages, researchers generated mouse models with hematopoietic deletion of TIF1γ. [Dev Biol] Abstract

2-(Trimethylammonium)Ethyl (R)-3-Methoxy-3-Oxo-2-Stearamidopropyl Phosphate Promotes Megakaryocytic Differentiation of Myeloid Leukemia Cells and Primary Human CD34+ Hematopoietic Stem Cells
The authors showed that 2-(trimethylammonium)ethyl (R)-3-methoxy-3-oxo-2-stearamidopropyl phosphate, a derivative of an organic chemical identified from a natural product library, promotes highly efficient differentiation of megakaryocytes. [J Tissue Eng Regen Med]
Abstract

The Effect of Granulocyte Colony Stimulating Factor Receptor Gene Missense Single Nucleotide Polymorphisms on Peripheral Blood Stem Cell Enrichment
Researchers asked whether the missense single nucleotide polymorphisms in granulocyte-colony stimulating factor (G-CSF) could affect the response to G-CSF in hematopoietic stem cell transplantation patients and donors. [Cytokine] Abstract

CLINICAL RESEARCH

High-Dose Vincristine Sulfate Liposome Injection for Advanced, Relapsed, and Refractory Adult Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia
Sixty-five adults with Philadelphia chromosome-negative acute lymphoblastic leukemia in second or greater relapse or whose disease had progressed following two or more leukemia therapies were treated in this pivotal phase II, multinational trial. [J Clin Oncol] Abstract

Model-Based Decision Rules Reduce the Risk of Molecular Relapse after Cessation of Tyrosine Kinase Inhibitor Therapy in Chronic Myeloid Leukemia
Molecular response to imatinib in chronic myeloid leukemia is associated with a biphasic but heterogeneous decline of BCR-ABL transcript levels. The authors analyzed this inter-individual heterogeneity and provide a predictive mathematical model to prognosticate the long-term response and the individual risk of molecular relapse upon treatment cessation. [Blood] Abstract

Treosulfan-Thiotepa-Fludarabine Based Conditioning Regimen for Allogeneic Transplantation in Patients with Thalassemia Major: A Single Center Experience from North India
Researchers analyzed the safety and efficacy of treosulfan/thiotepa/fludarabine based conditioning regimen for allogeneic stem cell transplantation in thalassemia major patients. [Biol Blood Marrow Transplant] Abstract

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REVIEWS
Discovery and Validation of Graft-versus-Host Disease Biomarkers
This review identifies biomarkers for detecting graft-versus-host disease (GVHD), summarizes current information on acute GVHD biomarkers, proposes future prospects for the blinded evaluation of these biomarkers, and discusses the need for biomarkers of chronic GVHD. [Blood] Abstract
INDUSTRY NEWS

Elsevier Launches New Open Access Journal: ‘Leukemia Research Reports’
Leukemia Research Reports, a sister journal to the prestigious publication Leukemia Research, will deliver timely information online to all health care professionals involved in basic and/or applied clinical research in leukemias, lymphomas, multiple myeloma and other hematologic malignancies. [Elsevier B.V.]
Press Release

UC-Davis and StemCyte Announce Cord Blood Banking Partnership
SStemCyte, Inc. proudly announces an agreement with the UC Davis Umbilical Cord Blood Collection Program in Sacramento to advance the collection, processing and registration of high quality and diverse cord blood cells from California mothers for public banking. [StemCyte Inc.] Press Release

Stem Cell Pioneer Recognized for 20 Years of Discovery and Innovation
Dr. David Harris, Professor of Immunology at the University of Arizona and a scientific pioneer in the field of stem cell banking, was the recipient of the Arizona BioIndustry Association™ 2012 award for “20 Years of Discovery and Innovation”. [PR Newswire Association LLC] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW World Stem Cells & Regenerative Medicine Congress 2013
May 21-23, 2013
London, United Kingdom

Visit our events page to see a complete list of events in the hematopoietic community.

JOB OPPORTUNITIES

Product Quality Scientist (STEMCELL Technologies, Inc.)

Scientist – Endothelial Cell Research (STEMCELL Technologies, Inc.)

Research Technologist – Cell Separation (STEMCELL Technologies, Inc.)

Scientist or Engineer – hPSC Bioengineer (STEMCELL Technologies, Inc.)

Quality Control Analyst (STEMCELL Technologies, Inc.)

Scientist, Postdoctoral and Research Associate Positions (University of Miami – Sylvester Comprehensive Cancer Center)

Postdoctoral Position – Tumor Stem Cells (Cancer Institute of New Jersey)

Senior Lecturer – Cancer Stem Cells (The European Cancer Stem Cell Research Institute)

Postdoctoral Position – Hematopoietic Stem Cell and Leukemia Research (City of Hope Beckman Research Institute) 

Assistant Professor – Myelodysplastic Syndromes (MD Anderson Cancer Center)

Postdoctoral Position – Extension of the Hough Transform and Applications to the Imaging of the Hematopoietic System (Università degli Studi di Genova)


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