Volume 3.39 | Oct 2

Hematopoiesis News 3.39 October 2, 2012
Hematopoiesis News
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TOP STORY
Spleens of Myelofibrosis Patients Contain Malignant Hematopoietic Stem Cells
Myelofibrosis (MF) is characterized by hematopoiesis occurring not only in the marrow but also in extramedullary sites such as the spleen. To study the effects of these different microenvironments on primitive malignant hematopoietic cells, researchers phenotypically and functionally characterized splenic and peripheral blood MF CD34+ cells from patients with MF. [J Clin Invest] Full Article

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PUBLICATIONS (Ranked by impact factor of the journal)

LABORATORY RESEARCH

Systems-Pharmacology Dissection of a Drug Synergy in Imatinib-Resistant Chronic Myeloid Leukemia
Integration of genome- and proteome-wide technologies enabled the elucidation of the mechanism by which a new drug synergy targets the dependency of BCR-ABLT315I chronic myeloid leukemia cells on c-Myc through nonobvious off targets. [Nat Chem Biol] Abstract

NOTCH1 Nuclear Interactome Reveals Key Regulators of Its Transcriptional Activity and Oncogenic Function
Using immunoaffinity purification, researchers identified NOTCH1 nuclear partners in T cell acute lymphoblastic leukemia cells and showed that NOTCH1 assembles a multifunctional complex containing the transcription coactivator AF4p12, the PBAF nucleosome remodeling complex, and the histone demethylases LSD1 and PHF8 acting through their demethylase activity to promote epigenetic modifications at Notch-target genes. [Mol Cell] Abstract | Graphical Abstract

Human Hematopoietic Stem/Progenitor Cells Overexpressing Smad4 Exhibit Impaired Reconstitution Potential In Vivo
Findings demonstrated that the Smad signaling circuitry negatively regulates the regeneration capacity of human hematopoietic stem/progenitor cells in vivo. [Blood] Abstract

The BAF53a Subunit of SWI/SNF-Like BAF Complexes Is Essential for Hemopoietic Stem Cell Function
Scientists provided the first evidence that the actin-related protein BAF53a, a subunit of BAF complexes preferentially expressed in long-term repopulating stem cells, is essential for adult hemopoiesis. [Blood] Abstract

Characterization of the Effects of Exercise Training on Hematopoietic Stem Cell Quantity and Function
Investigators aimed to determine whether exercise training could expand the bone marrow hematopoietic stem cell (HSC) pool, and influence various aspects of HSC function. [J Appl Physiol] Abstract

Clonal Heterogeneity in Cytogenetically Normal Acute Myeloid Leukemia Patients with NPM1 Mutations
Data demonstrated that nucleophosmin 1 (NPM1)-mutated cytogenetically normal acute myeloid leukemia originates in an early stem cell with both lymphoid and myeloid differentiation potential. [Leuk Lymphoma] Abstract

Compromised Hematopoiesis and Increased DNA Damage following Non-Lethal Ionizing Radiation of a Human Hematopoietic System Reconstituted in Immunodeficient Mice
Researchers evaluated the effects of non-lethal doses of X-ray irradiation on human hematopoietic stem and progenitor cells reconstituted in NOD/Shi-scid, IL2Rγnull immunodeficient mice. [Int J Radiat Biol] Abstract

Effect of Acute Lung Injury on VLA-4 and CXCR4 Expression in Resident and Circulating Hematopoietic Stem/Progenitor Cells
Scientists aimed to determine whether there is a relationship between pulmonary inflammation, expression of VLA-4, LFA-1, L-selectin, CXCR4, and chemotaxis in resident hematopoietic stem/progenitor cells (HSPCs), as well as the level of circulating HSPCs. [Respiration] Abstract

CLINICAL RESEARCH

Acute Myeloid Leukemia with Translocation (8;16)(p11;p13) and MYST3-CREBBP Rearrangement Harbors a Distinctive MicroRNA Signature Targeting RET Proto-Oncogene
Researchers concluded that acute myeloid leukemia with t(8;16)(p11;p13) harbors a specific microRNA signature which is partially epigenetically regulated and which targets RET proto-oncogene. [Leukemia] Abstract

Association of Disparities in Known Minor Histocompatibility Antigens with Relapse-Free Survival and Graft-versus-Host-Disease after Allogeneic Stem Cell Transplantation
Investigators evaluated whether mismatches in a panel of seventeen minor histocompatibility antigens are associated with clinical outcome after partial T cell-depleted allogeneic stem cell transplantation. [Biol Blood Marrow Transplant] Abstract

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REVIEWS

The p53 Pathway in Hematopoiesis: Lessons from Mouse Models, Implications for Humans
Most of the understanding of p53 function in hematopoiesis is derived from genetically engineered mice. Here, researchers summarized some of these models, the various mechanisms that disrupt the regulation of p53 activity, and their relevance to human disease. [Blood] Abstract

Higher Order Orchestration of Hematopoiesis: Is Cohesin a New Player?
Scientists suggested that cohesin, which is known to mediate chromosomal cohesion between sister chromatids, may have a central role in the orchestration of hematopoiesis and may serve as a master transcriptional regulator. [Exp Hematol] Abstract

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INDUSTRY NEWS

UCSD-Based Cancer Consortium Receives Five-Year, $20 Million Grant Renewal
An international consortium of scientists studying chronic lymphocytic leukemia, based at the University of California, San Diego (UCSD) School of Medicine, has been awarded a five-year, $20 million grant by the National Cancer Institute, part of the National Institutes of Health. [UC San Diego Health System]
Press Release

NextBio Teams with Emory University for Cancer Biomarker Discovery: NextBio Clinical to be Used for Translational Research Focused on Multiple Myeloma
NextBio announced a partnership with Emory University and its Winship Cancer Institute using genomic data to identify unique biomarkers and treatments for patients with multiple myeloma. [NextBio] Press Release

DACOGEN® Approved in the European Union for the Treatment of Acute Myeloid Leukemia
Astex Pharmaceuticals, Inc. announced that Janssen-Cilag International NV was notified that the European Commission has approved the marketing authorization for DACOGEN® for the treatment of adult patients with newly diagnosed de novo or secondary acute myeloid leukemia (AML) who are not candidates for standard induction chemotherapy. DACOGEN also has been granted Orphan Drug designation for the treatment of AML. [Astex Pharmaceuticals, Inc.] Press Release

Seattle Genetics and Millennium Complete Enrollment in Phase III AETHERA Trial of ADCETRIS® for Post-Transplant Patients with Hodgkin Lymphoma
Seattle Genetics, Inc. and Millennium: The Takeda Oncology Company announced the completion of patient enrollment in a phase III clinical trial of ADCETRIS for post-transplant Hodgkin lymphoma patients. [Seattle Genetics, Inc.] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW 3rd Emirates Haematology Conference (EHC2013)
March 7-9, 2013
Dubai, United Arab Emirates

Visit our events page to see a complete list of events in the hematopoietic community.
JOB OPPORTUNITIES

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)


Research Technologist – Research and Development (STEMCELL Technologies, Inc.)

Scientific Communications and Publishing Coordinator (STEMCELL Technologies, Inc.)


Product Manager – Hematopoietic (STEMCELL Technologies, Inc.)


Research Associate – Quality Assurance (University of California)

Postdoctoral Position – Mouse Stem Cell Biology (University of Alabama)

Postdoctoral Position – Stem Cells and Cancer (Tsinghua University)

Scientist, Postdoctoral and Research Associate Positions (University of Miami – Sylvester Comprehensive Cancer Center)

Postdoctoral Position – Impact of Inflammation on Hematopoiesis and Cancer (University of Murcia)


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