Volume 3.11 | Mar 20

Hematopoiesis News 3.11, March 20, 2012
Hematopoiesis News
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
The DEAH-Box Helicase RHAU Is an Essential Gene and Critical for Mouse Hematopoiesis
Previous report showed RHAU mRNA expression to be elevated in human lymphoid and CD34+ bone marrow cells, suggesting a potential role in hematopoiesis. Here scientists generated a conditional knockout of the RHAU gene in mice. [Blood] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Salidroside Stimulates DNA Repair Enzyme Parp-1 Activity in Mouse HSC Maintenance
Researchers show that Salidroside prevented the loss of hematopoietic stem cells (HSCs) in mice under oxidative stress. [Blood] Abstract

An Insertional Mutagenesis Screen Identifies Genes That Cooperate with Mll-AF9 in a Murine Leukemogenesis Model
Data identified genes that define transcription factor networks and important genetic pathways acting during progression of leukemia induced by MLL fusion oncogenes. [Blood] Abstract

Norepinephrine Reuptake Inhibition Promotes Mobilization in Mice: Potential Impact to Rescue Low Stem Cell Yields
The mechanisms mediating hematopoietic stem and progenitor cell mobilization by G-CSF are complex. Researchers show that G-CSF likely alters sympathetic tone directly and that methods to increase adrenergic activity in the bone marrow microenvironment enhance progenitor mobilization. [Blood] Abstract

Concomitant Inactivation of Rb and E2f8 in Hematopoietic Stem Cells Synergizes to Induce Severe Anemia
In an effort to understand whether Rb function can be mediated by E2F transcription factors in a bone marrow-derived hematopoietic system in mice, investigators uncovered a functional synergy between Rb and E2F8 to promote erythropoiesis and to prevent anemia. [Blood] Abstract

Myeloid Leukemia Factor Is a Conserved Regulator of RUNX Transcription Factor Activity Involved in Hematopoiesis
Scientists report that myeloid leukemia factor mlf controls the homeostasis of the Drosophila hematopoietic system. [Proc Natl Acad Sci USA] Abstract

A Model for Personalized In Vivo Analysis of Human Immune Responsiveness
Researchers demonstrated robust immune reconstitution in mice with hematopoietic stem cells aspirated from bone marrow of adults with type 1 diabetes and healthy control volunteers. [Sci Transl Med]
Abstract | Press Release

CLINICAL RESEARCH

Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia
Investigators performed a mutational analysis of 18 genes in 398 patients younger than 60 years of age who had acute myeloid leukemia and who were randomly assigned to receive induction therapy with high-dose or standard-dose daunorubicin. [New Engl J Med] Abstract | Press Release

Clonal Architecture of Secondary Acute Myeloid Leukemia
Scientists performed whole-genome sequencing of seven paired samples of skin and bone marrow in seven subjects with secondary acute myeloid leukemia (AML) to identify somatic mutations specific to secondary AML. [New Engl J Med] Abstract | Press Release

Phase II Study of the JAK Kinase Inhibitor Ruxolitinib in Patients with Refractory Leukemias, Including Post Myeloproliferative Neoplasms (MPN) Acute Myeloid Leukemia (AML)
Scientists conducted a phase II study of ruxolitinib in patients with relapsed/refractory leukemias. [Blood] Abstract

Favorable Effect of Priming with Granulocyte Colony-Stimulating Factor in Remission Induction of Acute Myeloid Leukemia Restricted to Dose-Escalation of Cytarabine
Researchers randomized 917 acute myeloid leukemia patients to receive granulocyte colony-stimulating factor (G-CSF) (456 patients) or no G-CSF (461 patients) at the days of chemotherapy. [Blood] Abstract

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INDUSTRY NEWS

The Leukemia & Lymphoma Society and Epizyme Announce Achievement of Pre-Clinical Milestone in DOT1L Personalized Therapeutic Partnership
The Leukemia & Lymphoma Society and Epizyme announced that they have achieved a pre-clinical milestone in their partnership to develop Epizyme’s DOT1L-targeted histone methyltransferase inhibitor for Mixed Lineage Leukemia. [Epizyme, Inc.] Press Release


TetraLogic Pharmaceuticals Appoints C. Glenn Begley as Senior Vice President Research and Development
TetraLogic Pharmaceuticals announced the appointment of C. Glenn Begley as senior vice president of research and development. [TetraLogic Pharmaceuticals] Press Release

POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
EVENTS
NEW 13th Annual Conference of the Canadian Blood and Marrow Transplant Group
April 11-14, 2012
Toronto, Canada

Visit our events page to see a complete list of events in the hematopoietic community
JOB OPPORTUNITIES

Scientist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies Inc.)

Business Analyst – Product Management (STEMSOFT Software Inc.)

Postdoctoral Fellow in Cytokine Signaling in Hematopoietic Stem Cells (University of Pennsylvania School of Medicine)


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