Volume 3.09 | Mar 6

Hematopoiesis News 3.09, March 6, 2012
Hematopoiesis News
     In this issue: Publications | Science News | Industry News | Policy News | Events | Jobs
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A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage
Using in vivo RNAi screens, scientists identified basic leucine zipper transcription factor, ATF-like (BATF) as a major component limiting self-renewal of hematopoietic stem cells in response to telomere dysfunction and γ-irradiation. [Cell] Abstract

Read White Paper: Increase Success Rate Of Compounds In Toxicity Testing
PUBLICATIONS (Ranked by Impact Factor of the Journal)

Hematopoietic Stem Cell Subtypes Expand Differentially During Development and Display Distinct Lymphopoietic Programs
Adult hematopoietic stem cells (HSCs) with serially transplantable activity comprise two subtypes. Researchers show that both HSC subtypes are present in the fetal liver (at a 1:10 ratio) with the rarer, lymphoid-deficient HSCs immediately gaining an increased representation in the fetal bone marrow, suggesting that the marrow niche plays a key role in regulating their ensuing preferential amplification. [Cell Stem Cell] Abstract

Trophoblasts Regulate the Placental Hematopoietic Niche through PDGF-B Signaling
Investigators identified PDGF-B signaling in trophoblasts as a key component of the unique placental hematopoietic microenvironment that protects hematopoietic stem/progenitor cells from premature differentiation. [Dev Cell] Abstract | Press Release

An Acute Negative Bystander Effect of γ-Irradiated Recipients on Transplanted Hematopoietic Stem Cells in Mice
In this study, researchers found that irradiated mouse recipients significantly impaired the long-term repopulating ability of transplanted mouse hematopoietic stem cells shortly (~17 hours) after exposure to irradiated hosts and before the cells began to divide. [Blood] Abstract

Chromatin Occupancy Analysis Reveals Genome-Wide GATA Factor Switching during Hematopoiesis
Here investigators demonstrate on a genome wide scale that the hematopoietic GATA factors GATA-1 and GATA-2 bind overlapping sets of genes, often at distinct sites, as a means to differentially regulate target gene expression and to regulate the balance between proliferation and differentiation. [Blood] Abstract

Early Ontogenic Origin of the Hematopoietic Stem Cell Lineage
To de-convolute hematopoietic ontogeny, scientists designed an embryo-rescue system in which the key hematopoietic factor Runx1 is reactivated in Runx1-null conceptuses at specific developmental stages. [Proc Natl Acad Sci USA] Abstract

Frequent Loss of RAF Kinase Inhibitor Protein Expression in Acute Myeloid Leukemia
Researchers investigated RAF kinase inhibitor protein’s role in acute myeloid leukemia, an aggressive malignancy arising from hematopoietic stem and progenitor cells. [Leukemia] Abstract

Interleukin-27 Inhibits the Growth of Pediatric Acute Myeloid Leukemia in NOD/SCID/Il2rg−/− Mice
Scientists investigated whether interleukin-27, an immunomodulatory cytokine, functions as an antitumor agent against pediatric acute myeloid leukemia cells. [Clin Cancer Res] Abstract

Role of Macrophages in Mobilization of Hematopoietic Progenitor Cells from Bone Marrow After Hemorrhagic Shock
In this study, scientists investigated the mechanism of hemorrhagic shock with resuscitation regulation of hematopoietic progenitor cell mobilization from bone marrow. [Shock] Abstract


Correlation of CD33 Expression Level with Disease Characteristics and Response to Gemtuzumab Ozogamicin Containing Chemotherapy in Childhood AML
CD33 mean fluorescent intensity of leukemic blasts was prospectively quantified in 619 de novo pediatric acute myeloid leukemia patients enrolled on Children’s Oncology Group gemtuzumab ozogamicin-containing clinical trials and correlated with disease characteristics and clinical outcome. [Blood] Abstract

Allogeneic Hematopoietic Stem Cell Transplantation Following Reduced-Intensity Conditioning Regimen in Children: A Single Center Experience
This single-center retrospective study reported the outcome of 19 children treated with a reduced-intensity conditioning regimen prior to allogeneic stem cell transplantation, for hematologic malignancies (n=17), bone marrow failure (n=1) and neuroblastoma (n=1). [Eur J Haematol] Abstract

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Gene Therapy Success in Third Immune Disease
Doctors report that five patients with x-CGD have responded to gene therapy, showing clear clinical benefit. In this gene therapy, a virus acts as a vector, to put a working copy of the gene concerned into a sample of the patient’s blood stem cells. These modified blood stem cells are reintroduced to the body and then produce the necessary working cells for the immune system. [Great Ormond Street Hospital for Children] Press Release

Polaris Group Doses First Patient in Phase I Clinical Trial of Lead Therapeutic Candidate ADI-PEG 20 in Pediatric Patients with Emphasis on Leukemia, Lymphoma and Sarcoma
Polaris Group announced that it has dosed the first patient in a Phase I clinical trial evaluating its lead cancer therapeutic, pegylated arginine deiminase (ADI-PEG 20), in pediatric patients with emphasis on leukemia, lymphoma and sarcoma cancers. [Polaris Group] Press Release
Pediatric Research Institute Launched by Children’s Medical Center, UT Southwestern
Children’s Medical Center is partnering with the University of Texas (UT) Southwestern Medical Center to establish a unique $150 million venture that will bring together the finest scientists to pursue research with the potential to change scientific fields, as well as the way disease is treated in children and adults. [University of Texas Southwestern Medical Center] Press Release

American Society of Hematology Announces 2012 Translational Research Training in Hematology Program Participants
The American Society of Hematology and the European Hematology Association announce the names of 20 early-career hematologists chosen to participate in the 2012 Translational Research Training in Hematology joint program. [American Society of Hematology] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)
Center for Biologics Evaluation and Research (United States)
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 4th International Congress on Stem Cell and Tissue Formation: Quantitative Stem Cell Biology – From Models to Applications
July 18-20, 2012
Dresden, Germany

NEW Stem Cell Society Singapore Symposium 2012
September 6-7, 2012
Singapore, Singapore

Visit our events page to see a complete list of events in the hematopoietic community

Scientist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist (STEMCELL Technologies Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies Inc.)

Business Analyst – Product Management (STEMSOFT Software Inc.)

Postdoctoral Fellow in Cytokine Signaling in Hematopoietic Stem Cells (University of Pennsylvania School of Medicine)

Postdoctoral Fellow in Stem Cells and Cancer (Tsinghua University)

Postdoctoral/Research Associate (Children’s Memorial Research Center)

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