Volume 3.02 | Jan 17

Hematopoiesis News 3.02, January 17, 2012
Hematopoiesis News
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Engraftment of Human HSC in Non-Irradiated Newborn NOD-ScidIL2rγNull Mice Is Enhanced by Transgenic Expression of Membrane-Bound Human Stem Cell Factor
Scientists hypothesized that transgenic expression of human membrane-bound stem cell factor Tg(hu-mSCF) would increase levels of human hematopoietic stem cell (HSC) engraftment in non-irradiated NOD-scidIL2rγnull mice and eliminate complications associated with irradiation. [Blood] Abstract

Watch The Video: Performing CFC Assays Using MethoCult™
PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

ABCB6 Is Dispensable for Erythropoiesis and Specifies the New Blood Group System Langereis
Investigators identified ABCB6 as the genetic basis of the Lan blood group antigen expressed on red blood cells but also at the plasma membrane of hepatocellular carcinoma cells, and they established that ABCB6 encodes a new blood group system (Langereis, Lan). [Nat Genet] Abstract

CD27 Signaling on Chronic Myelogenous Leukemia Stem Cells Activates Wnt Target Genes and Promotes Disease Progression
In the present study, researchers investigated the possibility that the TNF receptor family member CD27 is present on leukemia stem cells and mediates effects of the immune system on chronic myelogenous leukemia. [J Clin Invest] Abstract

The Mitochondrial Transporter ABC-Me (ABCB10), a Downstream Target of GATA-1, Is Essential for Erythropoiesis In Vivo
Here scientists report for the first time that erythrocyte development in mice requires ATP binding cassette mitochondrial erythroid (ABC-me/ABCB10). [Cell Death Differ] Abstract

Alternative Splicing of Bim and Erk-Mediated BimEL Phosphorylation Are Dispensable for Hematopoietic Homeostasis In Vivo
Researchers conclude that physiological regulation of Bim relies on mechanisms independent of its alternative splicing or the Erk-dependent phosphorylation of BimEL. [Cell Death Differ] Abstract

Chromatin Modifications Induced by the AML1-ETO Fusion Protein Reversibly Silence its Genomic Targets through AML1 and Sp1 Binding Motifs
ChIP-chip analysis of human hematopoietic stem/progenitor cells transduced with the AML1-ETO fusion gene enabled scientists to identify 1168 AML1-ETO target genes, 103 of which were co-occupied by histone deacetylase 1 and had lost the hyperacetylation mark at histone H4, and 264 showed a K9 trimethylation at histone H3. [Leukemia] Abstract

Integrated Genomic Analyses Identify WEE1 as a Critical Mediator of Cell Fate and a Novel Therapeutic Target in Acute Myeloid Leukemia
Using novel molecular and computational approaches, researchers performed genome-wide short-hairpin RNA screens to identify proteins that mediate acute myeloid leukemia (AML) cell fate after cytarabine exposure; gene expression profiling of AML cells exposed to cytarabine to identify genes with induced expression in this context; and examination of existing gene expression data from primary patient samples. [Leukemia] Abstract

Disseminated Prostate Cancer Cells Can Instruct Hematopoietic Stem and Progenitor Cells to Regulate Bone Phenotype
Investigators examined if metastatic prostate cancer cells can alter regulation of normal bone formation by hematopoietic stem cells and hematopoietic progenitor cells. [Mol Cancer Res] Abstract

Ectopic Expression of the Histone Methyltransferase Ezh2 in Hematopoietic Stem Cells Causes Myeloproliferative Disease
Here scientists show that induced Ezh2 hematopoietic expression increases the number and proliferation of repopulating hematopoietic stem cells. [Nat Commun] Abstract

CLINICAL RESEARCH

Clonal Evolution in Relapsed Acute Myeloid Leukemia Revealed by Whole-Genome Sequencing
To determine the mutational spectrum associated with relapse, researchers sequenced the primary tumor and relapse genomes from eight acute myeloid leukemia patients, and validated hundreds of somatic mutations using deep sequencing; this allowed them to define clonality and clonal evolution patterns precisely at relapse. [Nature] Abstract | Press Release

The Dynamic International Prognostic Scoring System for Myelofibrosis Predicts Outcomes After Hematopoietic Cell Transplantation
Investigators evaluated the prognostic usefulness of the Dynamic International Prognostic Scoring System in 170 patients with myelofibrosis, 12-78 (median: 51.5) years of age, who received hematopoietic cell transplantation between 1990-2009 from related (n=86) or unrelated donors (n=84). [Blood] Abstract

High-Resolution Genomic Profiling of Adult and Pediatric Core-Binding-Factor Acute Myeloid Leukemia Reveals New Recurrent Genomic Alterations
To identify cooperating lesions in core-binding factor acute myeloid leukemia, investigators performed single-nucleotide polymorphism-array analysis on 300 diagnostic and 41 relapse adult and pediatric leukemia samples. [Blood] Abstract

Unmanipulated HLA-Mismatched/Haploidentical Peripheral Blood Stem Cell Transplantation for High-Risk Hematologic Malignancies
The aim of this study was to investigate the efficacy and safety of unmanipulated haploidentical allogeneic peripheral blood stem cell transplantation for hematologic malignancies. [Transfusion] Abstract

Complimentary Wallchart: Identification Of Colonies Derived From Mouse Hematopoietic Progenitors

INDUSTRY NEWS
Kedem Pharmaceuticals Initiates Development of Sublingual Anti-Cancer Drug, Gleevec®
Kedem Pharmaceuticals Inc. announced that has initiated the development of Gleevec®. Gleevec® is an important anti-cancer drug for the treatment of several blood related cancers in children and adults. [Kedem Pharmaceuticals, Inc.] Press Release

Akinion Pharmaceuticals Initiates Phase I/II Clinical Trial with AKN-028
Akinion Pharmaceuticals AB announced that the first patient has been dosed with AKN-028 in a Phase I/II clinical trial in acute myeloid leukemia. [Akinion Pharmaceuticals AB] Press Release

Damon Runyon Grants Fellowship and Breakthrough Scientist Awards to 21 Top Young Scientists
The Damon Runyon Cancer Research Foundation named 18 new Damon Runyon Fellows at its fall Fellowship Award Committee review. [Damon Runyon Cancer Research Foundation] Press Release

CIFAR Announces Dr. Alan Bernstein, O.C. As New President and CEO
On behalf of the Board of the Canadian Institute for Advanced Research (CIFAR), David Dodge announced the appointment of Dr. Alan Bernstein as the Institute’s new President and CEO commencing May 1, 2012. [Canadian Institute for Advanced Research] Press Release
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
EVENTS
NEW 8th Annual Swiss Stem Cell Network Meeting
February 10, 2012
Zurich, Switzerland

NEW Keystone Symposia on Molecular and Cellular Biology: Cancer and Metabolism
February 12-17, 2012
Banff, Canada

NEW 2nd EACR-OECI Joint Training Course: Molecular Pathology Approach to Cancer
May 7-9, 2012
Amsterdam, Netherlands

Visit our events page to see a complete list of events in the hematopoietic community
JOB OPPORTUNITIES

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Postdoctoral Researchers (Centre for Cancer Biology)

Postdoctoral/Research Associate (Children’s Memorial Research Center)

PhD Research Fellowship, Centre for Molecular Medicine (University of Oslo)

Pediatric Faculty – Hematology/Oncology Stem Cell Sciences (The University of Chicago)

Postdoctoral Research Fellow (Cancer Research UK)

Physician – Hematology/Oncology (Veterans Affairs)

Postdoctoral Positions in Stem Cell Biology (Columbia University)

Professorship in Hematopoietic Stem Cell Transplantation and Head (University of Göttingen)


Postdoctoral Position – Center for Human Genetics (VIB Research Institute)


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