Volume 3.01 | Jan 10

Hematopoiesis News 3.01, January 10, 2012
Hematopoiesis News
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Bone Marrow Homing and Engraftment of Human Hematopoietic Stem and Progenitor Cells Is Mediated by a Polarized Membrane Domain
Here, researchers show that increased cell cycling during ex vivo culture of hematopoietic stem/progenitor cells results in disruption of a membrane domain, as evidence by disruption of polarity of the tetraspanin CD82. [Blood] Abstract

See Recommendations: Reducing Immunosuppression Testing By Using Customized Assays To Evaluate Myelotoxicity First
PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

p38 MAPK Inhibition Suppresses the TLR-Hypersensitive Phenotype in FANCC- and FANCA-Deficient Mononuclear Phagocytes
Reasoning that suppression of inhibitory cytokine production might enhance hematopoiesis, researchers screened small molecules using TLR-agonist-stimulated FANCC- and FANCA-deficient macrophages containing an NF-kappaB/AP-1 responsive reporter gene. [Blood] Abstract

SIRT1 Is Dispensable for Function of Hematopoietic Stem Cells in Adult Mice
Herein researchers perform a comprehensive in vivo study of the hematopoietic stem cell (HSC) compartment in adult SIRT1-deficient animals and show that, apart from anemia and leukocytosis in older mice, production of mature blood cells, lineage distribution within hematopoietic organs and frequencies of the most primitive HSC populations are comparable to those of wild type littermate controls. [Blood] Abstract

A Human ESC Model for MLLAF4 Leukemic Fusion Gene Reveals an Impaired Early Hematopoietic-Endothelial Specification
This work illustrates how human embryonic stem cells (ESCs) may provide unique insights into human development and further the understanding of how leukemic fusion genes, known to arise prenatally, regulate human embryonic hematopoietic specification. [Cell Res] Abstract

GSK3 Is a Regulator of RA Receptor-Mediated Differentiation
Here researchers show that the combination of all-trans retinoic acid (ATRA) with GSK3 inhibition significantly enhances ATRA-mediated acute myeloid leukemia differentiation and growth inhibition. [Leukemia] Abstract

Bmi1 Is Critical to Prevent Ikaros-Mediated Lymphoid Priming in Hematopoietic Stem Cells
Researchers’ results indicate that Ikaros is a critical Bmi1 target in vivo that prevents premature lineage specification of hematopoietic stem cells. [Cell Cycle] Abstract

Erythroid-Specific Expression of ß-Globin from Sleeping Beauty-Transduced Human Hematopoietic Progenitor Cells
In this study researchers utilized the non-viral sleeping beauty (SB) transposon system using the SB100X hyperactive transposase to transduce human cord blood CD34+ cells with DsRed and a hybrid IHK-ß-globin transgene. [PLoS One] Abstract

Role of the Common γ Chain in Cell Cycle Progression of Human Malignant Cell Lines
In this study, researchers evaluate whether γ-chain expression could interfere in cell cycle progression in malignant hematopoietic cells. [Int Immunol] Abstract

CLINICAL RESEARCH

Chronic Phase Chronic Myeloid Leukemia Patients with Low OCT-1 Activity Randomized to High-Dose Imatinib Achieve Better Responses, and Lower Failure Rates, Than Those Randomized to Standard-Dose
In this study the predictive value of OCT-1 activity, in the setting of 400 and 800mg/day imatinib dosing, and trough imatinib plasma levels were assessed in 100 patients enrolled to the TOPS study. [Haematologica] Abstract

FMS-Like Tyrosine Kinase 3 Internal Tandem Duplication and the Patterns of Its Gene Sequence in 207 Chinese Patients with De Novo Acute Myeloid Leukemia
Researchers’ objective was to study the patterns of FMS-like tyrosine kinase 3-internal tandem duplication in Chinese patients with acute myeloid leukemia. [Arch Pathol Lab Med] Abstract

Distinctive MicroRNA Signature Is Associated with the Diagnosis and Prognosis of Acute Leukemia
Researchers’ results support that microRNA (miR)-128, let-7b, miR-223 and miR181a have a diagnosis value in acute leukemia, while miR-181a and miR-155 are of great prognostic significance in acute myeloid leukemia. [Med Oncol] Abstract

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INDUSTRY NEWS

Akinion Pharmaceuticals Initiates Phase I/II Clinical Trial with AKN-028
Akinion Pharmaceuticals AB announced that the first patient has been dosed with AKN-028 in a Phase I/II clinical trial in acute myeloid leukemia. [Akinion Pharmaceuticals AB] Press Release

BerGenBio Completes $9 Million Series A Financing for First in Class Oncology Therapeutics
BerGenBio AS announced it has completed an $8.8 million Series A financing round. This financing will be used primarily to take lead compound BGB324 into clinical trials and to develop a companion diagnostic. [BerGenBio AS] Press Release

Micromet Signs CRADA with National Cancer Institute to Expand Development of Blinatumomab
Micromet announced that it has entered into a Cooperative Research and Development Agreement (CRADA) with the National Cancer Institute to expand development of blinatumomab in patients with acute lymphoblastic leukemia and various sub-types of lymphoma. [Micromet] Press Release

NeoGenomics Enters into Exclusive Worldwide Licensing Agreement with Health Discovery Corporation
NeoGenomics, Inc. announced that it has licensed from Health Discovery Corporation (HDC) the exclusive worldwide rights to utilize HDC’s extensive intellectual property portfolio to develop laboratory developed tests and other products relating to hematopoietic and solid tumor cancers. [NeoGenomics, Inc.]
Press Release

Michelle Spence Named New AMGA Vice President of Public Policy
The American Medical Group Association (AMGA) announced that Michelle Spence is joining the organization as Vice President of Public Policy, effective immediately. [American Medical Group Association]
Press Release

POLICY NEWS

FDA Warns About Stem Cell Claims
The Food and Drug Administration (FDA) cautions consumers to make sure that any stem cell treatment they are considering has been approved by FDA or is being studied under a clinical investigation that has been submitted to and allowed to proceed by FDA. [Food and Drug Administration, United States] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW Centre for Regenerative Medicine: Driving Stem Cell Research Towards Therapy
May 12-22, 2012
Edinburgh, United Kingdom

NEW 4th International Conference on Stem Cells and Tissue Formation
July 18-20, 2012
Dresden, Germany

Visit our events page to see a complete list of events in the hematopoietic community

JOB OPPORTUNITIES

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Postdoctoral/Research Associate (Children’s Memorial Research Center)

PhD Research Fellowship, Centre for Molecular Medicine (University of Oslo)

Pediatric Faculty – Hematology/Oncology Stem Cell Sciences (The University of Chicago)

Postdoctoral Research Fellow (Cancer Research UK)

Physician – Hematology/Oncology (Veterans Affairs)

Postdoctoral Positions in Stem Cell Biology (Columbia University)

Professorship in Hematopoietic Stem Cell Transplantation and Head (University of Göttingen)


Postdoctoral Position – Center for Human Genetics (VIB Research Institute)


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